1
Lloyd A Marks: Aperture occlusion device. Temple University, Ratner & Prestia, April 28, 1992: US05108420 (779 worldwide citation)

A device consisting of a wire for occluding an aperture within a body surface, such as atrial and ventricular septal defects (and the method of using such a device). The wire comprises two configurations, an elongated configuration for passage into said body through a catheter and through the apertu ...


2
Alexander A Sapega, Ray A Moyer, Donald Rose: Apparatus and method for reconstructive surgery. Temple University, Austin R Miller, April 26, 1988: US04739751 (294 worldwide citation)

A method and apparatus for the permanent surgical reconstruction of the anterior cruciate ligament in the human knee, which will stabilize the tibia and femur relative to each other and restore a full range of motion to the knee, by precisely locating the ends and angular relationship of a replaceme ...


3
Thomas H Shaffer, Marla R Wolfson, Thomas F Miller, Raymond Foust III: Breathable liquid elimination analysis. Temple University Of The Commonwealth System of Higher Education, Seidel Gonda Lavorgna & Monaco P C, January 7, 1997: US05590651 (264 worldwide citation)

The amount of breathable liquid eliminated from a mammal through volatilization in the lungs and/or through skin transpiration is detected by measuring the amount of saturation of the expiratory gas by vapors or the breathable liquid. Instantaneous saturation values are employed to gauge the amount ...


4
Robert J Suhadolnik, Wolfgang Pfleiderer: Dual action 2,5-oligoadenylate antiviral derivatives and uses thereof. Temple University Of The Commonwealth System Of Higher Education, Seidel Gonda Lavorgna & Monaco P C, August 27, 1996: US05550111 (243 worldwide citation)

Viral infection is inhibited in mammals by administration of metabolically stable, non-toxic 2', 5'-oligoadenylate (2-5A) derivatives that have a dual therapeutic effect. The compounds activate the intracellular latent 2-5A dependent endoribonuclease RNase L and also inhibit the action of viral DNA ...


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Robert J Suhadolnik, Wolfgang Pfleiderer: Encapsulated 2,5-phosphorothioate oligoadenylates. Temple University of the Commonwealth System of Higher Education, Seidel Gonda Lavorgna & Monaco, February 23, 1993: US05188897 (236 worldwide citation)

Optically active compounds of the formula ##STR1## wherein n is 1 or 2 and m is 0, 1, 2 or 3 have antiviral activity. Compounds of the formula wherein at least one of the internucleotide phosphorothioate linkages is


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Robert J Suhadolnik, Wolfgang Pfleiderer: 2,5-phosphorothioate oligoadenylates and their covalent conjugates with polylysine. Temple University of the Commonwealth System of Higher Education, Seidel Gonda Lavorgna & Monaco, April 11, 1995: US05405939 (232 worldwide citation)

Optically active compounds of the formula ##STR1## wherein n is 1 or 2 and m is 0, 1, 2 or 3 have antiviral activity. Compounds of the formula wherein at least one of the internucleotide phosphorothioate linkages is of the Sp configuration possess increased antiviral activity and/or metabolic stabil ...


8
Robert G Stern, Thomas H Shaffer, Marla R Wolfson: Fluorochemical liquid augmented cryosurgery. Temple University of the Commonwealth System of Higher Education, Seidel Gonda Lavorgna & Monaco PC, April 21, 1998: US05741248 (228 worldwide citation)

A method for cryogenic treatment of a lesion which includes the steps of delivering a fluorochemical liquid to the lesion, placing at least one cryoprobe into the lesion, and circulating cryogenic fluid through the cryoprobe, the cryogenic fluid causing an ice ball to form in a vicinity around the c ...


9
K Michael Sekins, Thomas H Shaffer, Marla R Wolfson: Lung cancer hyperthermia via ultrasound and/or convection with perfiuorochemical liquids. Biopulmonics, Temple University Of the Commonwealth System of Higher Education, Seidel Gonda Lavorgna & Monaco, October 27, 1992: US05158536 (183 worldwide citation)

A hyperthermic treatment of lung cancer, by temporarily filling with a liquid medium preselected pulmonary air passages adjoining pulmonary tissues containing malignant cells, circulating exogenously heated liquid medium at from about 41.degree. to ab


10
Alan M Gewirtz, Bruno Calabretta: Antisence oligonucleotides to c-myb proto-oncogene and uses thereof. Temple University of the Commonwealth System of Higher Education, Seidel Gonda Lavorgna & Monaco, March 24, 1992: US05098890 (117 worldwide citation)

Oligonucleotides are provided having a nucleotide sequence complementary to at least a portion of the mRNA transcript of the human c-myb gene. These "antisense" oligonucleotides are hybridizable to the c-myb mRNA transcript. Such oligonucleotides are useful in treating hematologic neoplasms and in i ...