Akira Suzuki, Hiroshi Miura, Saburo Matsuda, Takashi Ohsawa: Method of preparing a controlled release liquid pharmaceutical composition. Tanabe Seiyaku, Bierman & Bierman, April 5, 1977: US04016100 (106 worldwide citation)

A pharmaceutical composition is prepared by the steps of dispersing a phospholipid uniformly in water to give an aqueous phospholipid dispersion, adding a medicament to the aqueous dispersion, freezing the thus-obtained aqueous dispersion, thereby entrapping the medicament in the lipid spherules, an ...

Thomas J Lobl, Shiu Lan Chiang, Pina M Cardarelli: Cyclic cell adhesion modulation compounds. Tanabe Seiyaku, Spensley Horn Jubas & Lubitz, March 9, 1993: US05192746 (70 worldwide citation)

Cyclized integrin receptor antagonist compounds useful in modulating cell adhesion to integrin receptors, including adhesion related to fibronectin and/or fibronectin receptors, are disclosed. Methods for synthesizing, testing, formulating, and using the compounds as therapeutic agents are also disc ...

Masayoshi Samejima, Kazuo Noda, Masao Kobayashi, Takashi Osawa: Process for micronizing slightly-soluble drug. Tanabe Seiyaku, April 13, 1993: US05202129 (59 worldwide citation)

A process for micronizing a slightly-soluble drug characterized by subjecting a mixture of said drug and a sugar or sugar alcohol to high-speed stirring comminution or impact comminution in order to produce a micronized drug having an average diameter of less than about 2-3 mm. Also provided is a ph ...


Samejima Masayoshi, Hirata Goichi, Koida Yoshiyuki, Kobayashi Yoshinori, Kida Akira: Enteric microcapsules and process for the preparation thereof.. Tanabe Seiyaku Co, May 4, 1983: EP0077956-A1 (49 worldwide citation)

Novel enteric microcapsules containing an active compound as a core material, the coating walls of which consist essentially of ethylcellulose and an enteric polymer material, and optionally a water-swellable polymer material being incorporated into the core material, and a process for the preparati ...

Tetsu Hase, Harumi Masubuchi: Nucleic acid detection by repetitive synthesis and degradation of a nucleotide on a nuclease resistant oligonucleotide. Eiken Chemical, Tanabe Seiyaku, Fitzpatrick Cella Harper & Scinto, December 15, 1998: US05849487 (48 worldwide citation)

The present invention relates to a method of detecting a polynucleotide, comprising hybridizing a polynucleotide of known nucleotide sequence with a nuclease-resistant oligonucleotide primer having a sequence complementary to a part of the polynucleotide, then adding at least one kind of deoxynucleo ...

Witherington Jason, Elliott Richard Leonard: Process for preparing quinolin antibiotic intermediates. Tanabe Seiyaku, Witherington Jason, Elliott Richard Leonard, KAWAMIYA Osamu, February 19, 2004: WO/2004/014859 (48 worldwide citation)

The present invention relates to novel pyridone derivatives capable of inhibiting a4 integrin medicated cell adhesion, processes for their preparation, compositions comprising them and their use in the treatment of diseases capable of being modulated by the inhibition of cell adhesion.

Ichiro Chibata, Tetsuya Tosa, Isao Takata: Immobilized catalytically active substance and method of preparing the same. Tanabe Seiyaku, Bierman & Bierman, February 6, 1979: US04138292 (47 worldwide citation)

An enzyme or microorganism is entrapped within the gel matrix of a sulfated polysaccharide (said polysaccharide containing more than 10 w/w% of a sulfate moiety in its molecule) in the presence of ammonium ion, a metal ion, a water-soluble amine or a water-miscible organic solvent. The immobilized e ...

Ikuo Iijima, Masakatsu Ozeki, Kunihito Okumura, Masanori Inamasu: Benzoxazole derivatives. Tanabe Seiyaku, Scully Scott Murphy & Presser, August 14, 1990: US04948900 (47 worldwide citation)

Novel benzoxazole derivatives of the formula: ##STR1## wherein R is a substituted or unsubstituted phenyl group, a substituted or unsubstituted naphthyl group, a substituted or unsubstituted cycloalkyl group or a substituted or unsubstituted heterocyclic group; Alk is single bond, a substituted or u ...

Kazuo Noda, Yoshiyuki Hirakawa, Hiroyuki Yoshino, Shinji Narisawa: Controlled release succinic acid microcapsules coated with aqueous acrylics. Tanabe Seiyaku, Browdy and Neimark, March 7, 1995: US05395628 (43 worldwide citation)

A controlled release pharmaceutical preparation comprising (a) a core containing a pharmaceutically active substance and an organic acid, and (b) a coating film formed on the surface of the core by aqueous coating of a water-insoluble and water-slightly permeable acrylic polymer containing a trimeth ...