1
Tamaki Kazuhiko, Yamaguchi Takahiro, Oda Kozo, Terasaka Naoki, Nakai Daisuke, Nakadai Masakazu: (Ja) 2以上の置換基を有するベンゼン化合物, (En) Benzene compound having 2 or more substituents. Daiichi Sankyo Company, Tamaki Kazuhiko, Yamaguchi Takahiro, Oda Kozo, Terasaka Naoki, Nakai Daisuke, Nakadai Masakazu, YAGUCHI Toshiaki, May 4, 2006: WO/2006/046593 (45 worldwide citation)

(EN) Disclosed is an excellent LXR modulator. Specifically disclosed is a compound represented by the general formula (I) below or the like. (I) [In the formula, R1 represents a -COR9 (wherein R9 represents an alkyl, optionally substituted alkoxy or optionally substituted amino); R2 represents an H, ...


2
YAMAGUCHI Takahiro, YOSHIDA Masayuki, TAMAKI Kazuhiko: [ja] 置換ベンゼン化合物, [fr] COMPOSÉ DU BENZÈNE SUBSTITUÉ, [en] SUBSTITUTED BENZENE COMPOUND. YAMAGUCHI Takahiro, YOSHIDA Masayuki, TAMAKI Kazuhiko, SANKYO COMPANY, YAGUCHI Toshiaki, January 12, 2006: WO/2006/003923 (3 worldwide citation)

[en] Disclosed is an excellent LXR modulator. Specifically disclosed are compounds represented by the following general formula (I). (In the formula, R1 represents -COR9 (wherein R9 represents an alkyl, an optionally substituted alkoxy or an optionally substituted amino or the like), an optionally s ...


3
Arai Masami, Yamazaki Takanori, Tamaki Kazuhiko: (Ja) インドール化合物, (En) Indole compounds. Sankyo Company, Arai Masami, Yamazaki Takanori, Tamaki Kazuhiko, YAGUCHI Toshiaki, December 1, 2005: WO/2005/113499 (2 worldwide citation)

(EN) The invention provides excellent LXR regulators, that is, compounds represented by the general formula (I): wherein R1, R2, R3 and R4 are each H, alkyl, alkoxy, substituted amino, halogeno, or the like; R5 is H, alkyl, or halogeno; R6 is -COR8 (wherein R8 is alkoxy, phenyloxy, substituted amino ...


4
Tamaki Kazuhiko, Yamaguchi Takahiro, Terasaka Naoki: (Ja) 置換インドール化合物, (En) Substituted indole compound. Daiichi Sankyo Company, Tamaki Kazuhiko, Yamaguchi Takahiro, Terasaka Naoki, YAGUCHI Toshiaki, October 19, 2006: WO/2006/109633 (2 worldwide citation)

(EN) Disclosed is an excellent LXR modulator. A compound represented by the general formula (I): (I) wherein R1, R2, R3 and R4: H, an alkyl which may be substituted, OH, an alkoxy which may be substituted, an amino which may be substituted, a halogeno, a phenyl or the like; R5: H or an alkyl; R6: -C ...


5
Kimura Tomio, Tamaki Kazuhiko, Miyazaki Shoujiro, Kurakata Shinichi, Fujiwara Kosaku: Sulfonamide derivatives. Sankyo Company, Kimura Tomio, Tamaki Kazuhiko, Miyazaki Shoujiro, Kurakata Shinichi, Fujiwara Kosaku, OHNO Akio, April 5, 2001: WO/2001/023363

Compounds of general formula (I) exhibiting inhibitory activities against matrix metalloproteinase 13 and aggrecanase, wherein R?1¿ is OH or NHOH; R?2¿ is a group of general formula (II) or (III); A is alkylene which may be interrupted by an ether linkage or the like; R?3¿ is hydrogen, alkyl, or the ...


6
Seino Masahiro, Oboshi Minoru, Okoshi Satoshi, Tamaki Kazuhiko: Picker for hosiery machines. Nagata Seiki Kabushiki Kaisha, Seino Masahiro, Oboshi Minoru, Okoshi Satoshi, Tamaki Kazuhiko, SATO Kazuo, June 9, 1994: WO/1994/012712

A picker having a needle raising picker means (A) and a needle lowering picker means (B) which are used to increase and decrease stitches when a heel portion and a toe portion of a sock are knitted. When a longer butt (2a) of a knitting needle (2) at a knitting level impinges upon a free end portion ...


7
Sugimura Yukio, Tamaki Kazuhiko, Kobayashi Tomowo, Tanzawa Kazuhiko: Collagenase inhibitor. Sankyo Company, Sugimura Yukio, Tamaki Kazuhiko, Kobayashi Tomowo, Tanzawa Kazuhiko, NAKAMURA Minoru, May 13, 1993: WO/1993/009097

Constitution: a novel compound represented by general formula (1), wherein R?1¿ represents -OR?3¿ (R?3¿ being H or alkyl), -NR?4¿R?5¿ (R?4¿ and R?5¿ being each H, alkyl or alkoxy), -NHCH(R?6¿)COR?7¿ (R?6¿ being H or alkyl, and R?7¿ being alkyl), -NHCH(R?6¿)COOR?8¿(R?8¿ being alkyl) or -NHCH(R?6¿)CON ...


8
Shibata Tomoyuki, Ohkawa Nobuyuki, Takemoto Toshiyasu, Tamaki Kazuhiko, Kurihara Shinwa, Sato Susumu, Tanzawa Kazuhiko, Kobayashi Tomowo, Fujiwara Kosaku: Hyroxamic acid derivatives. Sankyo Company, Shibata Tomoyuki, Ohkawa Nobuyuki, Takemoto Toshiyasu, Tamaki Kazuhiko, Kurihara Shinwa, Sato Susumu, Tanzawa Kazuhiko, Kobayashi Tomowo, Fujiwara Kosaku, NAKAMURA Minoru, May 1, 1997: WO/1997/015553

Hydroxamic acid derivatives represented by general formula (1) or pharmacologically acceptable salts thereof which are excellent in the inhibitory activity on matrix metaproteinase and useful as a preventive and remedy for metastatic infiltration or multiplication of various cancer cells, arthrosis ...


9
Sato Susumu, Shibata Tomoyuki, Tamaki Kazuhiko, Tanzawa Kazuhiko, Kobayashi Tomowo, Fujiwara Kosaku: $G(b)-nonylhydroxamic acid derivatives. Sankyo Company, Sato Susumu, Shibata Tomoyuki, Tamaki Kazuhiko, Tanzawa Kazuhiko, Kobayashi Tomowo, Fujiwara Kosaku, NAKAMURA Minoru, October 31, 1996: WO/1996/033991

Compounds represented by general formula (1), having an excellent effect of inhibiting gelatinase, and being useful as a carcinostatic agent, a neovascularization suppressor, a cancerous infiltration suppressor or a cancerous metastasis suppressor, wherein R?1¿ represents 2-thienyl; R?2¿ represents ...


10
Shibata Tomoyuki, Ohkawa Nobuyuki, Takemoto Toshiyasu, Sato Susumu, Tamaki Kazuhiko, Kurihara Shinwa, Tanzawa Kazuhiko, Kobayashi Tomowo, Miura Shinichi: Hydroxamic acid derivatives. Sankyo Company, Shibata Tomoyuki, Ohkawa Nobuyuki, Takemoto Toshiyasu, Sato Susumu, Tamaki Kazuhiko, Kurihara Shinwa, Tanzawa Kazuhiko, Kobayashi Tomowo, Miura Shinichi, NAKAMURA Minoru, September 4, 1997: WO/1997/031892

Compounds represented by general formula (1), which have excellent inhibitory activities on matrix metaproteinases and are useful as a cancerous metastasis inhibitor, etc.; wherein R?1¿ represents optionally substituted C¿1-15? alkyl; R?2¿ represents H, hydroxy or C¿1-4? acyloxy; R?3¿ represents opt ...