Nishimura Osamu, Fujino Masahiko: Chemically modified lymphokine and production thereof.. Takeda Chemical Industries, September 11, 1985: EP0154316-A2 (337 worldwide citation)

The invention provides chemically modified lymphokines having R &lparstr& O-CH2CH2 &rparstr& n wherein R is a protective group for the terminal oxygen and n is an optional positive integer, bonded directly to at least one primary amino group of the lymphokine moiety, and a method of producing the sa ...



Okada Hiroaki, Kamei Shigeru, Yoshioka Toshio: Intravascular embolizing agent containing angiogenesis inhibiting substance.. Takeda Chemical Industries, February 12, 1992: EP0470569-A1 (109 worldwide citation)

The present invention relates to an intravascular embolizing agent containing an angiogenesis-inhibiting substance and an intravascular embolizing substance. The agent strengthens the antitumor effect of an angiogenesis-inhibiting substance and serves to reduce the dose and undesirable side effects. ...

Minamida Isao, Iwanaga Koichi, Okauchi Tetsuo: Alpha-unsaturated amines, their production and use.. Takeda Chemical Industries, February 8, 1989: EP0302389-A2 (103 worldwide citation)

alpha -Unsaturated amines of the formula: wherein X and X are such that one is an electron-attracting group with the other being a hydrogen atom or an electron-attracting group; R is a group attached through a nitrogen atom; R is a hydrogen atom or a group attached through a carbon, nitrogen or oxyg ...

Suzuki Nobuhiro, Odaka Asano, Kitada Chieko: Antibody against -g(b)-amyloid or derivative thereof and use thereof.. Takeda Chemical Industries, November 22, 1995: EP0683234-A1 (100 worldwide citation)

Novel antibodies useful because of having the binding specificity for beta -amyloid or derivatives thereof with beta -amyloid acting as an immunogen, or monoclonal antibodies which recognize the N-terminus, C-terminus and central portion, respectively, of beta -amyloid. The combination of these anti ...

Meguro Kanji, Fujita Takeshi: Thiazolidinedione derivatives, their production and use.. Takeda Chemical Industries, September 3, 1986: EP0193256-A1 (94 worldwide citation)

Thiazolidinedione derivatives of the formula: or pharmacologically acceptable salts thereof are novel compounds, which exhibit in mammals blood sugar- and lipid-lowering activity, and are of value as a therapeutic agent for diabetes and therapeutic agent for hyperlipemia.

Murakami Kazuo, Ueno Naoto, Kato Yukio: Protein, dna and use thereof.. Takeda Chemical Industries, Scitech Research, March 13, 1991: EP0416578-A2 (78 worldwide citation)

Disclosed are (1) a Xenopus laevis bone morphogenetic protein (BMP), (2) a DNA comprising a DNA segment coding for a Xenopus laevis BMP, (3) a transformant bearing a DNA comprising a DNA segment coding for a Xenopus laevis BMP and (4) a method for preparing the Xenopus laevis BMP which comprises cul ...


Naka Takehiko, Nishikawa Kohei, Kato Takeshi: Benzimidazole derivatives, their production and use.. Takeda Chemical Industries, December 4, 1991: EP0459136-A1 (77 worldwide citation)

Benzimidazole derivatives of the formula (I): wherein the ring A is a benzene ring which may optionally contain substitution in addition to the R' group; R is hydrogen or an optionally substituted hydrocarbon residue; R is a group capable of forming an anion or a group convertible thereinto; X is a ...