41
Osamu Miyashita, Hiroshi Akimoto: Maytansinoids, pharmaceutical compositions thereof and methods of use thereof. Takeda Chemical, Wegner & Bretschneider, April 7, 1981: US04260608 (93 worldwide citation)

Novel maytansinoids of the formula: ##STR1## wherein R.sup.1 is hydrogen atom, an alkyl group which may optionally be substituted or a group of the formula: --A.sup.1 --Y.sup.1 wherein A.sup.1 is an alkylene group or a bond, and Y.sup.1 is a cycloalkyl, phenyl, indolyl or imidazolyl group which may ...


42
Osamu Miyashita, Hiroshi Akimoto: Maytansinoids and use. Takeda Chemical, Davis Miller & Mosher Stevens, February 3, 1981: US04248870 (92 worldwide citation)

Novel maytansinoids of the formula: ##STR1## wherein R is an alicyclic hydrocarbon group of 3 to 10 carbon atoms, phenyl or heterocyclic group, which may optionally be substituted, and


43
Eiji Higashide, Mitsuko Asai, Seiichi Tanida: Method for producing maytansinol and its derivatives. Takeda Chemical, Wenderoth Lind & Ponack, April 24, 1979: US04151042 (92 worldwide citation)

Maytansinol, maytanacine or maytansinol propionate is (are) produced by cultivating a microorganism belonging to the genus Nocardia and being capable of producing maytansinol, maytanacine or maytansinol propionate, causing the microorganism to accumulate maytansinol, maytanacine or maytansinol propi ...


44
Osamu Miyashita, Hiroshi Akimoto: Maytansinoids. Takeda Chemical, Wegner & Bretschneider, January 5, 1982: US04309428 (92 worldwide citation)

Novel maytansinoids of the formula: ##STR1## wherein X is hydrogen or chlorine,


45
Osamu Miyashita, Hiroshi Akimoto: Maytansinoids, pharmaceutical compositions thereof and method of use thereof. Takeda Chemical, Wegner & Bretschneider, December 29, 1981: US04308269 (91 worldwide citation)

Novel maytansinoids of the formula: ##STR1## wherein X is H or Cl, and R is a hydrocarbon residue or an azaheterocyclic group, said R group having at least one of water-solubilizing substituents, have antimitotic, antitumor and antimicrobial activities.


46
Osamu Miyashita, Hiroshi Akimoto: Maytansinoids, pharmaceutical compositions thereof and method of use thereof. Takeda Chemical, Wegner & Bretschneider, December 29, 1981: US04308268 (91 worldwide citation)

Novel maytansinoids of the formula: ##STR1## wherein X is H or Cl, and Y is Cl, OH, SH, CN, NO.sub.2, --OR or --S(O).sub.n R wherein R is slkyl, aryl, aralkyl or azaheterocyclic group which may be substituted, and n is 0, 1 or 2, have antimitotic, antitumor and antimicrobial activities.


47
Yoshiyasu Furukawa, Shoji Kishimoto, Kohei Nishikawa: Hypotensive imidazole-5-acetic acid derivatives. Takeda Chemical, Wegner & Bretschneider, October 19, 1982: US04355040 (89 worldwide citation)

Novel imidazole-5-acetic acid derivatives of the formula: ##STR1## wherein R.sup.1 is lower alkyl, cycloalkyl or, phenyl which may be substituted with one to three of halogen, nitro, amino, mono(lower alkyl)amino, di(lower alkyl)amino, lower alkyl, lower alkoxyl, benzyloxyl or/and hydroxyl; X.sup.1, ...


48
Osamu Miyashita, Hiroshi Akimoto: Maytansinoids, their use and pharmaceutical compositions thereof. Takeda Chemical, Wegner & Bretschneider, March 2, 1982: US04317821 (89 worldwide citation)

Novel maytansinoids of the formula: ##STR1## wherein Y is H or Cl, and R is C.sub.2-15 alkyl, phenyl-C.sub.1-4 alkyl, pyridyl-C.sub.1-4 alkyl, imidazolyl-C.sub.1-4 alkyl, indolyl-C.sub.1-4 alkyl, furyl-C.sub.1-4 alkyl or thienyl-C.sub.1-4 alkyl, said R group being substituted by hydroxyl, halogen or ...


49
Toshio Yoshioka, Hiroaki Okada, Yasuaki Ogawa: Sustained release microcapsule for water soluble drug. Takeda Chemical, Wegner Cantor Mueller & Player, December 21, 1993: US05271945 (88 worldwide citation)

Sustained release microcapsules including a water soluble drug and an organic basic substance as a drug retaining substance of this invention not only have a high rate of incorporation (trapping rate), but also show little initial release so that they can be administered safely and bring about persi ...


50
Hiroaki Okada, Yasuaki Ogawa, Takatsuka Yashiki: Prolonged release microcapsules. Takeda Chemical, Wegner & Bretschneider, April 17, 1990: US04917893 (88 worldwide citation)

A microcapsule produced by preparing a water-in-oil emulsion comprising an inner aqueous layer containing said water-soluble drug and a drug retaining substance therefor and an oil layer containing a polymer substance, then thickening or solidifying said inner aqueous layer to a viscosity of not low ...