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Yasushi Nakagawa, Takashi Ito: Chemically modified protein with polyethyleneglycol. Takeda Chemical, Wegner & Bretschneider, December 13, 1988: US04791192 (352 worldwide citation)

The chemically modified protein of the present invention has a strong islet-activating activity and is lower in various side effects than non-modified IAP, so that it may be employed as a prevention and therapeutic drug for diabetes.


2
Nishimura Osamu, Fujino Masahiko: Chemically modified lymphokine and production thereof.. Takeda Chemical Industries, September 11, 1985: EP0154316-A2 (337 worldwide citation)

The invention provides chemically modified lymphokines having R &lparstr& O-CH2CH2 &rparstr& n wherein R is a protective group for the terminal oxygen and n is an optional positive integer, bonded directly to at least one primary amino group of the lymphokine moiety, and a method of producing the sa ...


3
Hiroaki Okada, Yasuaki Ogawa, Takatsuka Yashiki: Prolonged release microcapsule and its production. Takeda Chemical, Wegner & Bretschneider, March 24, 1987: US04652441 (258 worldwide citation)

A microcapsule produced by preparing a water-in-oil emulsion comprising an inner aqueous layer containing said water-soluble drug and a drug retaining substance therefor and an oil layer containing a polymer substance, then thickening or solidifying said inner aqueous layer to a viscosity of not low ...


4
Hideshi Okamoto, Yoshiki Maesaki, Hidekatsu Shoji, Isamu Tateishi, Takayuki Hagiwara, Tetsuya Hatono: Medicine container. Otsuka Pharmaceutical Factory, Takeda Chemical, Armstrong Westerman Hattori McLeland & Naughton, December 26, 1995: US05478337 (180 worldwide citation)

An outer tube having a double-ended needle accommodated therein upwardly and downwardly slidably is hermetically, removably but fixedly joined to an opening seal portion of a dissolving liquid container. An inner tube having a medicine-containing vial accommodated therein in an inverted state is joi ...


5
Kanji Meguro, Takeshi Fujita: Thiazolidinedione derivatives, useful as antidiabetic agents. Takeda Chemical, Wenderoth Lind & Ponack, August 18, 1987: US04687777 (169 worldwide citation)

Thiazolidinedione derivatives of the formula: ##STR1## and pharmacologically acceptable salts thereof are novel compounds, which exhibit in mammals blood sugar- and lipid-lowering activity, and are of value as a therapeutic agent for treatment of diabetes and hyperlipemia.


6
Tadashi Makino, Tetsuro Tabata, Shin ichiro Hirai: Spherical granules having core and their production. Takeda Chemical, Wegner Cantor Mueller & Player, June 25, 1991: US05026560 (162 worldwide citation)

The spherical granules having a core coated with spraying powder containing a drug and low substituted hydroxypropylcellulose, because of their excellent hardness, can be coated further evenly, (e.g. sustained release coating, gastric coating, enteric coating), and at the time the granules are excel ...


7
Shin ichiro Hirai, Hiroaki Okada, Takatsuka Yashiki: Takeda Chemical, Wenderoth Lind & Ponack, April 21, 1987: US04659696 (157 worldwide citation)

A pharmaceutical composition containing a hydrophilic drug which is poorly absorbable through the gastrointestinal tract, and cyclodextrin, increases the absorbability of the drug into the mammalian body when administered by a non-oral or non-injection route.


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Hiroaki Okada, Yasuaki Ogawa, Takatsuka Yashiki: Prolonged release microcapsule of a water-soluble drug. Takeda Chemical, Wegner Cantor Mueller & Player, October 29, 1991: US05061492 (155 worldwide citation)

A microcapsule produced by preparing a water-in-oil emulsion comprising an inner aqueous layer containing said water-soluble drug and a drug retaining substance therefor and an oil layer containing a polymer substance, then thickening or solidifying said inner aqueous layer to a viscosity of not low ...


9
Michihiko Ochiai, Taiiti Okada, Osami Aki, Akira Morimoto, Kenji Kawakita, Yoshihiro Matsushita: Thiazolylacetamido cephalosporin type compounds. Takeda Chemical, Wenderoth Lind & Ponack, July 4, 1978: US04098888 (150 worldwide citation)

Novel cephem compounds of the formula; ##STR1## wherein R.sup.1 represents amino or hydroxyl group which may be protected, R.sup.2 represents amino or hydroxyl group or a group convertible into these groups, R.sup.3 represents hydrogen or methoxy group or a group convertible into methoxy group, R.su ...


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