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De, Kock Herman Augustinus, Raboisson Pierre Jean Marie Bernard, Tahri Abdellah, Simmen Kenneth Alan, Nilsson Karl Magnus, Samuelsson Bengt Bertil, Rosenquist Åsa Annica Kristina, Antonov Dmitry: Macrocyclic inhibitors of hepatitis c virus. Tibotec Pharmaceuticals, Medivir, de, Kock Herman Augustinus, Raboisson Pierre Jean Marie Bernard, Tahri Abdellah, Simmen Kenneth Alan, Nilsson Karl Magnus, Samuelsson Bengt Bertil, Rosenquist Åsa Annica Kristina, Antonov Dmitry, DAELEMANS Frank, February 8, 2007: WO/2007/014920 (71 worldwide citation)

Inhibitors of HCV replication of formula (I), the N-oxides, salts, and stereochemically isomeric forms thereof, wherein each dashed line (represented by -------) represents an optional double bond; X is N, CH and where X bears a double bond it is C; R1 is aryl or a saturated, a partially unsaturated ...


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Raboisson Pierre Jean Marie Bernard, de, Kock Herman Augustinus, Vendeville Sandrine Marie Helene, Hu Lili, Van de, Vreken Wim, Mc, Gowan David Craig, Tahri Abdellah, Surleraux Dominique Louis Nestor Ghislain, Simmen Kenneth Alan: Macrocylic inhibitors of hepatitis c virus. Tibotec Pharmaceuticals, Raboisson Pierre Jean Marie Bernard, de, Kock Herman Augustinus, Vendeville Sandrine Marie Helene, Hu Lili, Van de, Vreken Wim, Mc, Gowan David Craig, Tahri Abdellah, Surleraux Dominique Louis Nestor Ghislain, Simmen Kenneth Alan, DAELEMANS Frank, February 8, 2007: WO/2007/014919 (63 worldwide citation)

Inhibitors of HCV of formula (I), and the N-oxides, salts, and stereochemically isomeric forms thereof, wherein R1 is aryl or a saturated, a partially unsaturated or completely unsaturated 5 or 6 membered monocyclic or 8 to 12 membered bicyclic heterocyclic ring system containing one nitrogen, and o ...


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Raboisson Pierre Jean Marie Bernard, de, Kock Herman Augustinus, Mc, Gowan David Craig, Van de, Vreken Wim, Hu Lili, Tahri Abdellah, Vendeville Sandrine Marie Helene: Macrocyclic inhibitors of hepatitis c virus. Tibotec Pharmaceuticals, Raboisson Pierre Jean Marie Bernard, de, Kock Herman Augustinus, Mc, Gowan David Craig, Van de, Vreken Wim, Hu Lili, Tahri Abdellah, Vendeville Sandrine Marie Helene, WANTE Dirk, May 22, 2008: WO/2008/059046 (35 worldwide citation)

Inhibitors of HCV replication of Formula (I) and the salts and stereoisomers thereof, wherein each dashed line (represented by - - - - -) represents an optional double bond; X is N, CH and where X bears a double bond it is C; R1 is -OR7, -NH-SO2R8; R2 is hydrogen, and where X is C or CH, R2 may also ...


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Van, Acker Koenraad Lodewijk August, Wigerinck Piet Tom Bert Paul, Michiels Lieve Emma Jan, Tahri Abdellah: Entry inhibitors of the hiv virus. Tibotec Pharmaceuticals, Van, Acker Koenraad Lodewijk August, Wigerinck Piet Tom Bert Paul, Michiels Lieve Emma Jan, Tahri Abdellah, DAELEMANS Frank, March 17, 2005: WO/2005/023242 (6 worldwide citation)

The present invention relates to small molecules as entry inhibitors of the HIV virus, processes for their preparation as well as pharmaceutical compositions, their use as medicines, and diagnostic kits comprising them. The present invention also concerns combinations of the present entry inhibitors ...


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Tahri Abdellah, Wigerinck Piet Tom Bert Paul: Broadspectrum substituted oxindole sulfonamide hiv protease inhibitors. Tibotec Pharmaceuticals, Tahri Abdellah, Wigerinck Piet Tom Bert Paul, DAELEMANS Frank, February 26, 2004: WO/2004/016619 (5 worldwide citation)

The present invention concerns the compounds having the formula (I) N-oxides, salts, stereoisomeric forms, racemic mixtures, prodrugs, esters and metabolites thereof, wherein R1 and R8 each are H, optionally substituted C 1-6alkyl, C2-6alkenyl, C3-7cycloalkyl, aryl, Het1, Het2; R1 may also be a radi ...


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