1
Edwin F Ullman, Moshe Schwarzberg: Fluorescence quenching with immunological pairs in immunoassays. Syva Company, Townsend and Townsend, December 7, 1976: US03996345 (858 worldwide citation)

Immunoassays employing antibodies and a fluorescer-quencher (F-Q) chromophoric pair, wherein one or both of the chromophoric pair are bonded to antibodies. Depending on the particular ligand of interest, various reagent combinations can be employed, where the amount of quenching is directly related ...


2
Henry K Tom, Gerald L Rowley: Concentrating zone method in heterogeneous immunoassays. Syva Company, Bertram I Rowland, December 28, 1982: US04366241 (765 worldwide citation)

Method and apparatus are provided for performing immunoassays employing a device comprising a relatively small test zone referred to as an immunosorbing zone, and a relatively large liquid absorbing zone in liquid receiving relationship with said immunosorbing zone. The immunosorbing zone includes a ...


3
David J Litman, Zvi Harel, Edwin F Ullman: Macromolecular environment control in specific receptor assays. Syva Company, Bertram I Rowland, June 23, 1981: US04275149 (636 worldwide citation)

Method and compositions are provided for performing protein binding assays involving a homologous pair consisting of ligand and receptor for the ligand. The method employs a label conjugated to a member of said homologous pair and a uniformly dispersed discontinuous phase of discrete particles in a ...


4
Edward T Maggio: Kit for carrying out chemically induced fluorescence immunoassay. Syva Company, Bertram I Rowland, July 7, 1981: US04277437 (378 worldwide citation)

A competitive protein binding method is provided for the determination of an analyte which is a member of an immunological pair consisting of ligand and receptor for the ligand. A chemiluminescent source is employed comprised of one or more individual members, one chemiluminescent source member bein ...


5
Kenneth Edward Rubenstein, Richard K Leute: Antibody steric hindrance immunoassay with two antibodies. Syva Company, Townsend and Townsend, January 27, 1976: US03935074 (321 worldwide citation)

A novel immunoassay is provided, as well as particular reagents, for determining the presence of a ligand. A Reagent is employed having at least two epitopes, one of the epitopes being common with the ligand, and the other epitopes being foreign to the ligand. The two epitopes are positioned in the ...


6
David J Litman, Edwin F Ullman: Test strip kits in immunoassays and compositions therein. Syva Company, Bertram I Rowland, July 5, 1983: US04391904 (243 worldwide citation)

An assay method and compositions are provided for determining the presence of an analyte in a sample. The analyte is a member of an immunological pair (mip) of immunogens--ligand and receptor. The method has two basic elements: a solid surface to which one of the members of the immunological pair is ...


7
David J Litman, Edwin F Ullman: Preferential signal production on a surface in immunoassays. Syva Company, Bertram I Rowland, November 10, 1981: US04299916 (216 worldwide citation)

An assay method and compositions are provided for determining the presence of an analyte in a sample. The analyte is a member of an immunological pair (mip) of immunogens--ligand and receptor. The method has two basic elements: a solid surface to which one of the members of the immunological pair is ...


8
Edward T Maggio, Richard L Wife, Edwin F Ullman: Reagents and method employing channeling. Syva Company, Bertram I Rowland, November 11, 1980: US04233402 (183 worldwide citation)

Method and compositions are provided for chemical analysis of an analyte which is a member of a specific binding pair of organic substances consisting of ligand and ligand receptor (antiligand). The method involves bringing together the following reagents with the analyte in an aqueous assay medium ...


9
Robert F Zuk, David J Litman: Immunochromatographic assay with support having bound "MIP" and second enzyme. Syva Company, Bertram I Rowland, March 6, 1984: US04435504 (174 worldwide citation)

Chromatographic immunoassay employing a specific binding pair member and a label conjugate which delineates a border whose distance from one end of the chromatograph relates to the amount of analyte present. By combining the label conjugate and sample in a solution and immunochromatographing the sol ...


10
Robert F Zuk, Ian Gibbons, Gerald L Rowley, Edwin F Ullman: Double antibody for enhanced sensitivity in immunoassay. Syva Company, Bertram I Rowland, July 28, 1981: US04281061 (173 worldwide citation)

Method and compositions are provided for performing homogeneous immunoassays. The method involves having a signal producing system, which provides a detectable signal, which system includes a macromolecular member. The determination of the analyte, which is a member of a specific binding pair consis ...