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Deborah A Eppstein, Philip L Felgner, Thomas R Gadek, Gordon H Jones, Richard B Roman: N[.omega.,(.omega.-1)-dialkyloxy]- and N-[.omega.,(.omega.-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor. Syntex, David A Lowin, Tom M Moran, January 30, 1990: US04897355 (361 worldwide citation)

This invention relates to compounds of the formula ##STR1## or an optical isomer thereof wherein R.sup.1 and R.sup.2 are the same or different and are an alkyl or alkenyl group of 6 to 24 carbon atoms; R.sup.3, R.sup.4 and R.sup.5 are the same or different and are alkyl of 1 to 8 carbon atoms, aryl, ...


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John S Kent, Danny H Lewis, Lynda M Sanders, Thomas R Tice: Microencapsulation of water soluble active polypeptides. Syntex, Ellen J Wise, Tom M Moran, Alan Krubiner, June 23, 1987: US04675189 (329 worldwide citation)

This invention concerns novel sustained release microcapsule compositions comprising water-soluble, hormonally active polypeptides and, optionally, a polymer hydrolysis modifying agent encapsulated in a biocompatible, biodegradable polymer.


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Edwin F Ullman, Pyare Khanna, Rohan Peries: Immunoassay device. Syntex, Gerald F Swiss, Theodore J Leitereg, August 15, 1989: US04857453 (278 worldwide citation)

A device is disclosed for conducting an assay method. The device comprises a housing, means enclosed in the housing for capturing a member of a specific binding pair in a zone and for allowing liquid to be transported by capillary action away from the zone, one or more self-contained liquid reagents ...


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Lynda M Sanders, Abraham Domb: Delayed/sustained release of macromolecules. Syntex, David A Lowin, John A Dhuey, September 25, 1990: US04959217 (253 worldwide citation)

This invention concerns novel, delayed/sustained release devices and compositions, including methods of their manufacture and use. The compositions include macromolecules, particularly polypeptide pharmaceuticals, and an initially partially-hydrated, non-biodegradable, hydrogel rate-limiting membran ...


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Hans Maag, Samuel J Rose, Beat Schmidt: Oligonucleotides containing 4-substituted nucleotides. Syntex, Shelley G Precivale, August 29, 1995: US05446137 (239 worldwide citation)

This invention relates to oligonucleotides having at least one nucleotide that is substituted at the 4' position of the sugar moiety with a substituent other than hydrogen. These oligonucleotides are useful in hybridization assays and as therapeutic agents.


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John S Kent: Cholesterol matrix delivery system for sustained release of macromolecules. Syntex, Ellen J Buckles, Tom M Moran, Alan M Krubiner, June 5, 1984: US04452775 (219 worldwide citation)

Delivery systems for releasing macromolecular active agents to a body site at a controlled rate for a prolonged period of time, comprising a cholesteric matrix permeable to passage of the macromolecular active agent by diffusion, are disclosed. The cholesteric matrix comprises cholesterol powder and ...


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Deborah A Eppstein, Brian B Schryver: Controlled release of macromolecular polypeptides. Syntex, Lester E Johnson, Tom M Moran, Alan M Krubiner, October 9, 1990: US04962091 (195 worldwide citation)

An active agent delivery system for the controlled administration of macromolecular polypeptides which comprises a micro-suspension of water-soluble components in a polylactide matrix.


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Norman G Gaylord: Method for correcting visual defects, compositions and articles of manufacture useful therein. Syntex, Alan M Krubiner, Joseph I Hirsch, October 17, 1978: US04120570 (181 worldwide citation)

Visual defects of the human eye in the form of refractive errors such as myopia, hyperiopia, astigmatism, athakis and keratoconus are corrected by a therapeutic method which includes the step of fitting to the patient's eye a corrective contact lens fabricated from a copolymer of a polysiloxanylalky ...


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Litai Weng, David Calderhead, Pyare Khanna, Edwin F Ullman: Concentrating immunochemical test device and method. Syntex, Theodore J Leitereg, April 26, 1988: US04740468 (167 worldwide citation)

A method and device for determining the presence of an analyte in a sample suspected of containing the analyte is disclosed. The method involves contacting a test solution containing the sample and a first member of a specific binding pair with an end portion of a strip of bibulous material capable ...