1
Bertin John, Grant Ethan P: Method for treating cancer. Synta Pharmaceuticals, Bertin John, Grant Ethan P, HSI Jeffrey D, November 30, 2006: WO/2006/128129 (89 worldwide citation)

The invention relates to a method for treating cancers using compounds that modulate the activity of c-Rel.


2
Sun Lijun, Zhang Shijie, Koya Keizo, Chimmanamada Dinesh, Li Hao, James David, Kostik Elena: Heteroaryl compounds. Synta Pharmaceuticals, Sun Lijun, Zhang Shijie, Koya Keizo, Chimmanamada Dinesh, Li Hao, James David, Kostik Elena, HSI Jeffrey D, May 18, 2006: WO/2006/053109 (55 worldwide citation)

This invention relates to compounds of formula (I) their compositions and methods of use thereof. The compounds (and compositions) are useful in modulating IL-12 production and processes mediated by IL-12.


3
Vo Nha Huu, Chen Shoujun, Che Qinglin, Xie Yu: Thiazole and thiadiazole compounds for inflammation and immune-related uses. Synta Pharmaceuticals, Vo Nha Huu, Chen Shoujun, Che Qinglin, Xie Yu, HSI Jeffrey D, August 2, 2007: WO/2007/087427 (52 worldwide citation)

The invention relates to compounds of structural formula (I) or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof, wherein R'i, X, X', L and Y are defined herein. These compounds are useful as immunosuppressive agents and for treating and preventing inflammatory conditions, ...


4
Babu Suresh R, Wada Yumiko, Shen Jack, Nguyen Nhung: Topical formulations for the treatment of psoriasis. Synta Pharmaceuticals, Babu Suresh R, Wada Yumiko, Shen Jack, Nguyen Nhung, HSI Jeffrey Det al, August 13, 2009: WO/2009/100406 (51 worldwide citation)

The invention relates to a topical composition and a method for treating psoriasis. The topical composisition comprises one or more compound that inhibits the production of IL- 12 and IL-23.


5
Mitsunori Ono, Lijun Sun, Yumiko Wada, Teresa Przewloka, Hao Li, Zachary Demko, Dinesh Chimmanamada: Fused heterocyclic compounds. Synta Pharmaceuticals, Edwards Angell Palmer & Dodge, Jeffrey D Hsi, Mark D Russett, November 10, 2009: US07615552 (50 worldwide citation)

This invention provides fused heterocyclic compounds, pharmaceutical compositions of the compounds, and methods of using the compounds for the treatment of, inter alia, IL-12 related disease and disorders.


6
Ying Weiwen, James David, Zhang Shijie, Przewloka Teresa, Chae Junghyun, Chimmanamada Dinesh U, Lee Chi Wan, Kostik Elena, Ng Howard P, Foley Kevin, Du Zhenjian, Barsoum James: Triazole compounds that modulate hsp90 activity. Synta Pharmaceuticals, Ying Weiwen, James David, Zhang Shijie, Przewloka Teresa, Chae Junghyun, Chimmanamada Dinesh U, Lee Chi Wan, Kostik Elena, Ng Howard P, Foley Kevin, Du Zhenjian, Barsoum James, DAVID Steven G, May 26, 2006: WO/2006/055760 (49 worldwide citation)

The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, s ...


7
Foley Kevin, Bertin John, Grant Ethan P: Method for treating b cell regulated autoimmune disorders. Synta Pharmaceuticals, Foley Kevin, Bertin John, Grant Ethan P, HSI Jeffrey D, November 30, 2006: WO/2006/128172 (42 worldwide citation)

The invention relates to a method for treating B-cell regulated autoimmune disorders using compounds that modulate the activity of c-Rel.


8
Sun Lijun, Borella Christopher, Li Hao, Jiang Jun, Chen Shoujun, Koya Keizo, Inoue Takayo, Du Zhenjian, Foley Kevin, Wu Yaming, Zhang Mei, Ying Weiwen: Isoxazole combretastin derivatives for the treatment of disorders. Synta Pharmaceuticals, Sun Lijun, Borella Christopher, Li Hao, Jiang Jun, Chen Shoujun, Koya Keizo, Inoue Takayo, Du Zhenjian, Foley Kevin, Wu Yaming, Zhang Mei, Ying Weiwen, DAVIS Steven G, August 24, 2006: WO/2006/089177 (40 worldwide citation)

The invention relates to compounds of structural formula (I); or a pharmaceutically acceptable salt, solvate, clathrate, and prodrug thereof, wherein Ra, Rb, and R2 are defined herein. These compounds inhibit tubulin polymerization and/or target vasculature and are useful for treating proliferative ...


9
Chen Shoujun, Sun Lijun, Xie Yu: Benzimidazolyl-pyridine compounds for inflammation and immune-related uses. Synta Pharmaceuticals, Chen Shoujun, Sun Lijun, Xie Yu, HSI Jeffrey D, October 4, 2007: WO/2007/112093 (38 worldwide citation)

The invention relates to compounds of formula (XVI): (XVI) or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof wherein Y2, Z, L1, R9, R10, m and u are defined herein. These compounds are useful as immunosuppressive agents and for treating and preventing inflammatory conditi ...


10
Koya Keizo, Sun Lijun, Wu Yaming, Korbut Timoty, Zhou Dan, Du Zhenjian, Chen Shoujun, Tatsuta Noriaki, Liang Guiqing, Ono Mitsunori: Bis (thio-hydrazide amide) compounds for treating multi-drug resistant cancer. Synta Pharmaceuticals, Koya Keizo, Sun Lijun, Wu Yaming, Korbut Timoty, Zhou Dan, Du Zhenjian, Chen Shoujun, Tatsuta Noriaki, Liang Guiqing, Ono Mitsunori, DAVIS Steven G, August 5, 2004: WO/2004/064826 (37 worldwide citation)

One embodiment of the present invention is a method of treating a subject with a multi-drug resistant cancer. The method comprises administering to the subject an effective amount of a compound represented by Structural Formula (I): Y is a covalent bond or a substituted or unsubstituted straight cha ...