1
Sun Lijun, Zhang Shijie, Koya Keizo, Chimmanamada Dinesh, Li Hao, James David, Kostik Elena: Heteroaryl compounds. Synta Pharmaceuticals, Sun Lijun, Zhang Shijie, Koya Keizo, Chimmanamada Dinesh, Li Hao, James David, Kostik Elena, HSI Jeffrey D, May 18, 2006: WO/2006/053109 (55 worldwide citation)

This invention relates to compounds of formula (I) their compositions and methods of use thereof. The compounds (and compositions) are useful in modulating IL-12 production and processes mediated by IL-12.


2
Sun Lijun, Borella Christopher, Li Hao, Jiang Jun, Chen Shoujun, Koya Keizo, Inoue Takayo, Du Zhenjian, Foley Kevin, Wu Yaming, Zhang Mei, Ying Weiwen: Isoxazole combretastin derivatives for the treatment of disorders. Synta Pharmaceuticals, Sun Lijun, Borella Christopher, Li Hao, Jiang Jun, Chen Shoujun, Koya Keizo, Inoue Takayo, Du Zhenjian, Foley Kevin, Wu Yaming, Zhang Mei, Ying Weiwen, DAVIS Steven G, August 24, 2006: WO/2006/089177 (40 worldwide citation)

The invention relates to compounds of structural formula (I); or a pharmaceutically acceptable salt, solvate, clathrate, and prodrug thereof, wherein Ra, Rb, and R2 are defined herein. These compounds inhibit tubulin polymerization and/or target vasculature and are useful for treating proliferative ...


3
Chen Shoujun, Sun Lijun, Xie Yu: Benzimidazolyl-pyridine compounds for inflammation and immune-related uses. Synta Pharmaceuticals, Chen Shoujun, Sun Lijun, Xie Yu, HSI Jeffrey D, October 4, 2007: WO/2007/112093 (38 worldwide citation)

The invention relates to compounds of formula (XVI): (XVI) or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof wherein Y2, Z, L1, R9, R10, m and u are defined herein. These compounds are useful as immunosuppressive agents and for treating and preventing inflammatory conditi ...


4
Koya Keizo, Sun Lijun, Wu Yaming, Korbut Timoty, Zhou Dan, Du Zhenjian, Chen Shoujun, Tatsuta Noriaki, Liang Guiqing, Ono Mitsunori: Bis (thio-hydrazide amide) compounds for treating multi-drug resistant cancer. Synta Pharmaceuticals, Koya Keizo, Sun Lijun, Wu Yaming, Korbut Timoty, Zhou Dan, Du Zhenjian, Chen Shoujun, Tatsuta Noriaki, Liang Guiqing, Ono Mitsunori, DAVIS Steven G, August 5, 2004: WO/2004/064826 (37 worldwide citation)

One embodiment of the present invention is a method of treating a subject with a multi-drug resistant cancer. The method comprises administering to the subject an effective amount of a compound represented by Structural Formula (I): Y is a covalent bond or a substituted or unsubstituted straight cha ...


5
Sun Lijun, Kostik Elena, Przewloka Teresa, Ng Howard P, Chimmanamada Dinesh, Demko Zachary: Il-12 modulatory compounds. Synta Pharmaceuticals, Sun Lijun, Kostik Elena, Przewloka Teresa, Ng Howard P, Chimmanamada Dinesh, Demko Zachary, HSI Jeffrey D, May 18, 2006: WO/2006/053227 (29 worldwide citation)

The invention relates to heterocyclic compounds, compositions including the compounds and methods of using and methods of making thereof. The compounds (and compositions) are useful, inter alia, in modulating IL-12 production and processes mediated by IL-12.


6
Xie Yu, Holmqvist Mats, Mahiou Jerome, Ono Mitsunori, Sun Lijun, Chen Shoujun, Zhang Shijie, Jiang Jun, Chimmanamada Dinesh, Fleig Andrea, Yu Chih Yi: Method for modulating calcium ion-release-activated calcium ion channels. Synta Pharmaceuticals, Xie Yu, Holmqvist Mats, Mahiou Jerome, Ono Mitsunori, Sun Lijun, Chen Shoujun, Zhang Shijie, Jiang Jun, Chimmanamada Dinesh, Fleig Andrea, Yu Chih Yi, HSI Jeffrey D, February 3, 2005: WO/2005/009954 (28 worldwide citation)

The invention relates to a method for modulating Ca 2'-release-activated Ca 2+ channels (CRAG) in a cell by administering to the cell a compound of formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof wherein X, Y, A, Z, L and n are defined herein.


7
Sun Lijun, Chen Shoujun, Jiang Jun, Xie Yu, Yu Chih Yi: Compounds for inflammation and immune-related uses. Synta Pharmaceuticals, Sun Lijun, Chen Shoujun, Jiang Jun, Xie Yu, Yu Chih Yi, HSI Jeffrey D, August 3, 2006: WO/2006/081391 (27 worldwide citation)

The invention relates to compounds of structural formula (I) and structural formula (Vl): or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof, wherein R, R1, R2, Z, L, and n are defined herein. These compounds are useful as immunosuppressive agents and for treating and prev ...


8
Sun Lijun, Demko Zachary, Wada Yumiko: 2-substituted heteroaryl compounds. Synta Pharmaceuticals, Sun Lijun, Demko Zachary, Wada Yumiko, HSI Jeffrey D, January 19, 2006: WO/2006/007532 (27 worldwide citation)

This invention relates to compounds of formula (I): or pharmaceutically acceptable salts, solvate, clathrates hydrates or polymorphs thereof, their compositions and methods of use and methods of making thereof. The compounds (and compositions) are useful in modulating IL-12 production and processes ...


9
Sun Lijun, Chen Shoujun, Jiang Jun, Xia Zhi Qiang, Xie Yu, Yu Chih Yi: Thiophene compounds for inflammation and immune-related uses. Synta Pharmaceuticals, Sun Lijun, Chen Shoujun, Jiang Jun, Xia Zhi Qiang, Xie Yu, Yu Chih Yi, HSI Jeffrey D, August 3, 2006: WO/2006/081389 (23 worldwide citation)

The invention relates to compounds of structural formulas (I) and (XVI) or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof, wherein X1, X2, Z, L, L2, R1, R2, R3, R21, n, q, and t are defined herein. These compounds are useful as immunosuppressive agents and for treating an ...


10
Sun Lijun, Chen Shoujun, Xia Zhi Qiang, Jiang Jun, Xie Yu, Zhang Junyi: Compounds for inflammation and immune-related uses. Synta Pharmaceuticals, Sun Lijun, Chen Shoujun, Xia Zhi Qiang, Jiang Jun, Xie Yu, Zhang Junyi, HSI Jeffrey D, August 10, 2006: WO/2006/083477 (23 worldwide citation)

The invention relates to compounds of structural formulas (I), (VII) and (Xl): or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof, wherein XI, X2, X3. Y, Z, L, R1, R2, R3, R18 and n are defined herein. These compounds are useful as immunosuppressive agents and for treating ...