1
Erik De Clercq, Antonin Holy, Ivan Rosenberg: Therapeutical application of phosphonylmethoxyalkyl adenines. Stichting Rega VZW, Ceskoslovenska Akademie VED, Birch Stewart Kolasch & Birch, February 9, 1988: US04724233 (53 worldwide citation)

The (S) and (RS) forms of certain phosphonylmethoxyalkyl adenines and their salts have an antiviral effect against several DNA viruses and can be used for the treatment of virus diseases in human and veterinary medicine.


2
Erik D A de Clercq, Piet A M M Herdewijn, Samuel Broder, Jan M R Balzarini: Therapeutic application of dideoxycytidinene. Stichting Rega VZW, The Government of the United States of America, Birch Stewart Kolasch & Birch, October 16, 1990: US04963533 (42 worldwide citation)

The present invention relates to a composition containing the compound 2', 3'-dideoxycytidinene which has an antiviral effect against human immunodeficiency virus (HIV) and may therefore be used as a therapeutic agent for the treatment of AIDS and AIDS related diseases.


3
Erik D A De Clercq, Piet A M Herdewijn, Arthur A E Van Aerschot: 1,5-anhydrohexitol nucleoside analogues. Stichting Rega VZW, Webb Ziesenheim Bruening Logsdon Orkin & Hanson P C, March 4, 1997: US05607922 (34 worldwide citation)

1,5-Anhydrohexitol nucleoside analogues represented by the general formula I: ##STR1## wherein the hexitol has the D-configuration and the carbon atom on which the base moiety and the X substituent stand both have the (S)-configuration and further wherein:


4
Jan M R Balzarini, Erik D A De Clercq: Combinations of TS-inhibitors and viral TK-inhibitors in antiherpetic medicines. Stichting Rega VZW, Webb Burden Ziesenheim & Webb, August 11, 1992: US05137724 (12 worldwide citation)

The antiviral activity of 5-fluoro-uracil, 5-fluoro-2'-deoxyuridine and similar thymilydate synthetase inhibitors towards herpes viruses can be potentiated dramatically by combining these compounds with compounds having viral thymidine kinase inhibiting activity.


5
Antonin Holy, Erik de Clercq: Antivirally active adenine derivatives. Ceskoslovenska Akademie Ved, Stichting Rega VZW, Birch Stewart Kolasch & Birch, August 12, 1986: US04605658 (11 worldwide citation)

Certain esters of 3-(adenin-9-yl)-2-hydroxypropanoic acid are disclosed which exhibit an improved broad spectrum antiviral activity while having a low toxicity for living cells. They can be used for treatment of virus diseases in human and veterinary practice.


6
Masanori Baba, Erik D A De Clercq, Sandor Gorog, Miklos Low, Miklos Nagy, Sandorne Gyorgyi: Sulphated vinyl polymers in compositions for treating retroviral infections. Stichting Rega VZW, Richter Gedeon Vegyeszeti Gyar R T, Webb Burden Ziesenheim & Webb P C, October 6, 1992: US05152978 (10 worldwide citation)

Sulphated vinyl polymers such as sulphated polyvinylalcohol, sulphated copolymers of (meth)acrylic acid and vinylalcohol, and pharmaceutically acceptable salts thereof, have an antiviral effect against human immunodeficiency virus and may therefore be used as a therapeutic agent for treating retrovi ...


7
Erik D A De Clercq, Piet A M M Herdewijn, Samuel Broder, Jan M R Balzarini: Therapeutic application of dideoxycytidinene. Stichting Rega VZW, The United States of America represented by the Department of Health and Human Serices, Birch Stewart Kolasch & Birch, May 26, 1992: US05116822 (7 worldwide citation)

The compound 2',3'-dideoxycytidinene has an antiviral effect against human immunodeficiency virus (HIV) and may therefore be used as a therapeutic agent for treating AIDS and related diseases.


8
Jo Van Damme, Paul Proost: Granulocyte chemotactic protein. Stichting Rega vzw, Hale and Dorr, November 24, 1998: US05840524 (6 worldwide citation)

This invention is directed to a new family of mammalian chemokine proteins, which have been designated granulocyte chemotactic protein-2 (GCP-2) proteins, and includes mammalian GCP-2, sequence-related variants of mammalian GCP-2, and distinct peptide fragments of GCP-2.


9
Masanori Baba, Erik D A De Clercq, Sandor Gorog, Miklos Low, Miklos Nagy, Sandorne Gyorgyi: Sulphated vinyl polymer in composition for treating retroviral infections. Stichting Rega VZW, Richter Gedeon Vegyeszeti Gyar RT, Webb Burden Ziesenheim & Webb, March 8, 1994: US05292505 (2 worldwide citation)

Sulphated vinyl polymers such as sulphated polyvinylalcohol, sulphated copolymers of (meth)acrylic acid and vinylalcohol, and pharmaceutically acceptable salts thereof, have an antiviral effect against human immunodeficiency virus and may therefore be used as a therapeutic agent for treating retrovi ...


10
Erik De Clercq, Masaaki Iigo: Combinations of FU and BVU as anti-adenocarcinoma agents. Stichting Rega VZW, Birch Stewart Kolasch & Birch, January 16, 1990: US04894365 (2 worldwide citation)

The antitumor activity of 5-fluorouracil and its precursors against adenocarcinomas can be potentiated without a corresponding increase in toxicity by combining these compounds with (E)-5-(2-bromovinyl)-uracil or a precursor thereof. The combinations may have the form of a single composition or two ...