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Curtin Michael L, Davidsen Steven K, Frey Robin R, Heyman Howard R, Holms James H, Michaelides Michael, Steinman Douglas H: Isoindolin-1-one compounds as kinase inhibitors. Abbott Laboratories, Curtin Michael L, Davidsen Steven K, Frey Robin R, Heyman Howard R, Holms James H, Michaelides Michael, Steinman Douglas H, STEELE Gregory, December 16, 2004: WO/2004/108672 (4 worldwide citation)

Compounds having the formula, (I) are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds and compositions containing the compounds.


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Summers James B, Sheppard George S, Phillips James G, Pireh Daisy, Steinman Douglas H, May Paul D, Guinn Denise E, Heyman H Robin, Carrera George M Jr, Davidsen Steven K: Indoles useful as platelet activating factor antagonists. Abbott Laboratories, Summers James B, Sheppard George S, Phillips James G, Pireh Daisy, Steinman Douglas H, May Paul D, Guinn Denise E, Heyman H Robin, Carrera George M Jr, Davidsen Steven K, sGORMAN Edward H Jr, September 3, 1992: WO/1992/014732

Indole compounds substituted at the 1- or 3-position by a (pyrid-3-yl)thiazolid-4-yl)alkyl-, (pyrid-3-yl)thiazolid-4-oyl)-, (pyrid-3-yl)dithiolan-4-yl)alkyl- or (pyrid-3-yl)dithiolan-4-oyl)- group are potent inhibitors of PAF and are useful in the treatment of PAF-related disorders including septic ...


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Summers James B, Davidsen Steven K, Holms James H, Pireh Daisy, Heyman H Robin, Martin Michael B, Steinman Douglas H, Sheppard George S, Carrera George M Jr: Platelet activating factor antagonists. Abbott Laboratories, Summers James B, Davidsen Steven K, Holms James H, Pireh Daisy, Heyman H Robin, Martin Michael B, Steinman Douglas H, Sheppard George S, Carrera George M Jr, GORMAN Edward H Jr, February 4, 1993: WO/1993/001813

Indole compounds substituted at the 3-position by a 7-carbonyl(pyridin-3-yl)pyrrolo[1,2-c]thiazole, 7-carbonyl(pyridin-3-yl)pyrrolo[1,2-c]oxazoline, or 7-carbonyl(pyridin-3-yl)pyrrolo[1,2-c]pyrrole group are potent antagonists of PAF and are useful in the treatment of PAF-related disorders including ...


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MICHAELIDES Michael R, CURTIN Michael L, HOLMS James H, STEINMAN Douglas H: [fr] INHIBITEUR DE KINASE AYANT UNE SOLUBILITÉ AMÉLIORÉE DANS LEAU, [en] KINASE INHIBITOR WITH IMPROVED AQUEOUS SOLUBILITY. MICHAELIDES Michael R, CURTIN Michael L, HOLMS James H, STEINMAN Douglas H, Abbott Laboratories, STEELE Susan L, January 24, 2013: WO/2013/012909

[en] 4-Amino-N- [3 -(diethylamino)propyl]-3 -(4- { [(3 - fluorophenyl)carbamoyl]amino}phenyl)thieno[3,2-c]pyridine-7-carboxamide which inhibits protein kinases such as Aurora-kinases and the VEGFR and PDGFR families of kinases, with an improved aqueous solubility profile, compositions containing 4-a ...