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Solberghe Geoffrey Fran├žois Freddy Ghislain, Schils Didier Philippe Robert, Stappers Alfred Elisabeth: Modified heck reaction. Janssen Pharmaceutica, Solberghe Geoffrey Fran├žois Freddy Ghislain, Schils Didier Philippe Robert, Stappers Alfred Elisabeth, JANSSEN PHARMACEUTICA, December 29, 2005: WO/2005/123662

The present invention includes a method for the preparation of a cinnamonitrile by addition of an aryl to acrylonitrile in the presence of a heterogeneous palladium catalyst, a phosphine, a base and a salt. The reaction can be conducted not only on aryl compounds activated with electron withdrawing ...


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Schils Didier Philippe Robert, Stappers Alfred Elisabeth: Process for preparing 4-[(1,6-dihydro-6-oxo-2-pyrimidinyl)amino benzonitrile. Tibotec Pharmaceuticals, Schils Didier Philippe Robert, Stappers Alfred Elisabeth, WANTE Dirk, November 30, 2006: WO/2006/125809

This invention relates to a process for preparing 4-[(1,6-dihydro-6-oxo-2-pyrimidinyl)- amino]benzonitrile (I) starting from a 4-oxo-1,6-dihydro-pyrimidinylcarboxylic acid ester (II) or starting from a guanidine derivative which is reacted with an alkoxy-methylene malonic acid ester to an ester (II) ...