1
Richard J Bram, Gotz Von Bulow: Lymphocyte surface receptor that binds CAML, nucleic acids encoding the same and methods of use thereof. St Jude Children s Research Hospital, Klauber & Jackson, October 19, 1999: US05969102 (63 worldwide citation)

A novel lymphocyte receptor protein, its DNA sequence, and its role in the calcium activation pathway is described. The protein, or genetically engineered constructs encoding it, are shown to increase lymphocyte response, and to identify ligands of the protein receptor. Antibodies to the proteins of ...


2
Marc R Sontag, Bentley H Burnham: Respiration responsive gating means and apparatus and methods using the same. St Jude Children s Research Hospital, Klauber & Jackson, June 13, 2000: US06076005 (53 worldwide citation)

A method and system for gating therapeutic or diagnostic energy to a tissue volume of a medical patient during a selected portion of the patient's respiratory cycle, to thereby diminish inaccuracies in the assumed spatial position of the tissue volume arising from displacements induced by the patien ...


3
Erich Hoffmann: DNA transfection system for the generation of infectious influenza virus. St Jude Children s Research Hospital, Darby & Darby, October 4, 2005: US06951754 (41 worldwide citation)

The present invention is based on the development of a dual promoter system (preferably a RNA pol I-pol II system) for the efficient intracellular synthesis of viral RNA. The resultant minimal plasmid-based system may be used to synthesize any RNA virus, preferably viruses with a negative single str ...


4
Robert Gordon Webster, Richard John Webby, Hiroichi Ozaki: Method for generating influenza viruses and vaccines. St Jude Children s Research Hospital, Shawn A Hawkins, May 2, 2006: US07037707 (40 worldwide citation)

The present invention is based on the discovery that a high titer reassortant influenza virus is produced in mammalian cell culture by replacing the NS gene of the A/PuertoRico/3/24 master strain with the NS gene of the A/England/1/53 strain. The invention provides influenza viruses and vaccines gen ...


5
Harriet L Robinson, Ellen F Fynan, Robert G Webster: Immunization by inoculation of DNA transcription unit. University of Massachusetts Medical Center, St Jude Children s Research Hospital, Hamilton Brook Smith & Reynolds P C, July 1, 1997: US05643578 (38 worldwide citation)

This invention relates to a method of immunizing a vertebrate, comprising introducing into the vertebrate a DNA transcription unit which comprises DNA encoding a desired antigen or antigens. The uptake of the DNA transcription unit by a host vertebrate results in the expression of the desired antige ...


6
Brian R Murphy, Robert M Chanock, Robert G Webster, Virginia S Hinshaw: Human use of avian-human reassortants as vaccines for influenza A virus. St Jude Children s Research Hospital, John S Roberts Jr, November 12, 1985: US04552758 (34 worldwide citation)

A method of producing a live attenuated vaccine useful in humans which comprises producing an influenza A reassortant virus by gene exchange between an avian influenza virus parent and a human influenza virus parent and then excluding the internal genes (that code for non-surface viral proteins) of ...


7
James N Ihle, Bruce A Witthuhn, Frederick W Quelle, Ollie Silvennoinen: Jak kinases and regulation of Cytokine signal transduction. St Jude Children s Research Hospital, Sterne Kessler Goldstein & Fox P L L C, March 17, 1998: US05728536 (30 worldwide citation)

The present invention is based on the discovery that a critical step in the cellular response to several cytokines is the activation (i.e. tyrosine phosphorylation) of a member of the Jak kinase family. In particular, several cytokines whose activity is mediated by the activation of Jak2 kinase are ...


8
Julia Hurwitz, Karen Slobod: Preparation and use of viral vectors for mixed envelope protein immunogenic composition against human immunodeficiency viruses. St Jude Children s Research Hospital, Klauber & Jackson, December 8, 1998: US05846546 (29 worldwide citation)

Polyenv immunogenic composition are provided that comprise mixtures of at least 4 different recombinant viruses that each express a different HIV env variant or a portion thereof containing both constant and variable regions, as well as methods of making and using such polyenv immunogenic compositio ...


9
James Ihle, Bruce A Witthuhn, Frederick W Quelle, Ollie Silvennoinen: Jak kinases and regulation of cytokine signal transduction. St Jude Children s Research Hospital, Sterne Kessler Goldstein & Fox PLLC, November 29, 2005: US06969760 (29 worldwide citation)

The invention relates generally to the Jak family of kinases. This includes the DNA and amino acid sequences for Jak 3 kinases. Additionally, the invention concerns expression vectors comprising DNA sequences encoding a Jak 3 kinase and host cell containing such expression vectors.


10
James Ihle, Bruce A Witthuhn, Ollie Silvennoinen: Jak kinases and regulations of cytokine signal transduction. St Jude Children s Research Hospital, Sterne Kessler Goldstein Fox P L L C, October 24, 2000: US06136595 (29 worldwide citation)

The invention relates generally to the Jak family of kinases. This includes the DNA and amino acid sequences for Jak 3 kinases. Additionally, the invention concerns expression vectors comprising DNA sequences encoding a Jak 3 kinase and host cell containing such expression vectors.



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