1
Marc R Sontag, Bentley H Burnham: Respiration responsive gating means and apparatus and methods using the same. St Jude Children&apos s Research Hospital, Klauber & Jackson, October 2, 2001: US06298260 (67 worldwide citation)

A method and system for gating therapeutic or diagnostic energy to a tissue volume of a medical patient during a selected portion of the patient's respiratory cycle, to thereby diminish inaccuracies in the assumed spatial position of the tissue volume arising from displacements induced by the p ...


2
Robert G Webster, Nicolai V Kaverin: Influenza virus replicated in mammalian cell culture and vaccine production. St Jude Children&apos s Research Hospital, Sterne Kessler Goldstein & Fox P L L C, February 5, 2002: US06344354 (41 worldwide citation)

The invention provides replication of high growth influenza virus strains, derived from clinical isolates, in cultured mammalian cells by infecting the mammalian cells with the high growth strains to obtain infected cells, and culturing the cells while maintaining a trypsin concentration range of 0. ...


3
Richard J Bram, Gotz Von Bulow: Nucleic acids encoding a lymphocyte surface receptor that binds CAML. St Jude Children&apos s Research Hospital, Klauber & Jackson, November 13, 2001: US06316222 (33 worldwide citation)

A novel lymphocyte receptor protein, its DNA sequence, and its role in the calcium activation pathway is described. The protein, or genetically engineered constructs encoding it, are shown to increase lymphocyte response, and to identify ligands of the protein receptor. Antibodies to the proteins of ...


4
Sanjiv Singh Samant, Jinesh Jitendra Jain, Joseph Laughter: Multilayered board comprising folded flexible circuits. St Jude Children&apos s Research Hospital, The University of Tennessee Research, Stephen Gigante, Klauber & Jackson, November 19, 2002: US06483713 (17 worldwide citation)

An easier and cheaper way to obtain multilayer circuit board is by using a flexible circuit board and folding it in an organized pattern. Flexible circuit has the unique property of being a three-dimensional circuit that can be shaped in multiplanar configurations, rigidized in specific areas, and m ...


5
Stephan W Morris, A Thomas Look: Method of detecting a chromosomal rearrangement involving a breakpoint in the ALK or NPM gene. St Jude Children&apos s Research Hospital, Sterne Kessler Goldstein & Fox P L L C, January 16, 2001: US06174674 (15 worldwide citation)

The present invention is based on the identification and sequence determination of a novel gene, ALK, which is fused to the gene encoding nucleophosmin (NPM) in translocations present in t(2;5) lymphoma cells. Based on homologies to other proteins, the amino acid sequence of the polypeptide encoded ...


6
Michael Kastan, Christine Canman, Seong Tae Kim, Dae Sik Lim: ATM kinase modulation for screening and therapies. St Jude Children&apos s Research Hospital, Johns Hopkins University, Darby & Darby, May 14, 2002: US06387640 (15 worldwide citation)

The present invention relates to identification of the consensus sequence phosphorylated by ATM kinase. This, in turn, permitted identification of ATM kinase target proteins, and development of a convenient assay system for ATM kinase phosphorylation using fusion polypeptides as substrates. The assa ...


7
Richard J Bram, Gotz Von Bulow: Antibodies to a lymphocyte surface receptor that binds CAML and methods of use thereof. St Jude Children&apos s Research Hospital, Alston & Bird, December 31, 2002: US06500428 (14 worldwide citation)

A novel lymphocyte receptor protein, its DNA sequence, and its role in the calcium activation pathway is described. The protein, or genetically engineered constructs encoding it, are shown to increase lymphocyte response, and to identify ligands of the protein receptor. Antibodies to the proteins of ...


8
Stephan W Morris, A Thomas Look: Kits for detecting chromosomal rearrangements. St Jude Children&apos s Research Hospital, Sterne Kessler Goldstein & Fox P L L C, September 17, 2002: US06451997 (12 worldwide citation)

The present invention is based on the identification and sequence determination of a novel gene, ALK, which is fused to the gene encoding nucleophosmin (NPM) in translocations present in t(2;5) lymphoma cells. Based on homologies to other proteins, the amino acid sequence of the polypeptide encoded ...


9
Charles O Rock, Richard John Heath: Enoyl reductases and methods of use thereof. St Jude Children&apos s Research Hospital, Licata & Tyrrell P C, September 2, 2003: US06613553 (11 worldwide citation)

The present provides structurally related enzymes that act as enoyl reductases. These enoyl reductases share a common amino acid consensus sequence, and bind a flavin cofactor. One particular enoyl reductase provided, FabK, catalyzes the identical reaction as the NADH-dependent enoyl-ACP reductase, ...


10
Charles J Sherr, Dawn Quelle, Martine F Roussel, Frederique Zindy, Jason D Weber: ARF-P19, a novel regulator of the mammalian cell cycle. St Jude Children&apos s Research Hospital, Klauber & Jackson, June 18, 2002: US06407062 (10 worldwide citation)

The INK4A (MTS1, CDKN2) gene encodes a specific inhibitor (InK4a-p16) of the cyclin D-dependent kinases CDK4 and CDK6. InK4a-p16 can block these kinase from phosphorylating the retinoblastoma protein (pRb), preventing exit from the G1 phase of the cell cycle. Deletions and mutations involving the ge ...



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