1
Spanholtz Jan: Methods and means for stem cell proliferation and subsequent generation and expansion of progenitor cells, as well as production of effector cells as clinical therapeutics.. Ipd Therapeutics, Spanholtz Jan, VAN LOON C J J, April 5, 2007: WO/2007/037682 (4 worldwide citation)

The invention provides means and methods for stem cell proliferation and subsequent generation and expansion of progenitor cells. The invention in particular provides media and other culture conditions for the same. The cells are preferably used as effector cells as clinical therapeutics.


2
Spanholtz Jan: Methods and means for stem cell proliferation and subsequent generation and expansion of progenitor cells, as well as production of effector cells as clinical therapeutics. Ipd Therapeutics, Spanholtz Jan, HATZMANN MJ, October 2, 2008: WO/2008/118020 (4 worldwide citation)

The invention is related to methods for expanding and differentiating hemopoietic progenitor cells in a medium comprising a collection of cytokines, desulphated glycosaminoglycan and human serum. The invention further relates to a collection of cells obtainable by a method of the invention, use of t ...


3
SPANHOLTZ Jan: GÉNÉRATION DE CELLULES NK ET DE PROGÉNITEURS DE CELLULES NK, GENERATION OF NK CELLS AND NK-CELL PROGENITORS. IPD THERAPEUTICS, SPANHOLTZ Jan, JANSEN C M, September 27, 2012: WO/2012/128622

The present invention provides a cytokine-based culture method for ex vivo expansion of NK cells from postembryonic hematopoietic stem cells into a fully closed, large-scale, cell culture bioprocess. We optimized enrichment of CD34 + cells followed by efficient expansion in gas-permeable cell cultur ...



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