1
Richard L Dunn, Robert A Casper: Method of producing biodegradable prosthesis and products therefrom. Southern Research Institute, Needle & Rosenberg, April 7, 1987: US04655777 (292 worldwide citation)

Method of producing biodegradable prostheses comprising a composite of resorbable fibers reinforcing a biodegradable polymer matrix and the use thereof in medical applications such as bone plates and other orthopedic devices. The fibers include ceramic powders, .beta.-TCP and CaAl and a biodegradabl ...


2
Thomas R Tice, Richard M Gilley: Drug delivery system and method of making the same. Southern Research Institute, Needle & Rosenberg, January 30, 1990: US04897268 (251 worldwide citation)

A compatible, biodegradable microcapsule delivery system for active ingredients, including hormonally active peptides, proteins, or other bioactive molecules, and a method of making the same. The ingredients are encapsulated in biodegradable copolymer excipients of varying mole ratios and the blend ...


3
Thomas R Tice, Danny H Lewis, Donald R Cowsar, Lee R Beck: Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents. The Stolle Research and Development Corporation, Southern Research Institute, Oblon Fisher Spivak McClelland & Maier, July 23, 1985: US04530840 (246 worldwide citation)

An anti-inflammatory agent containing microparticle composition prepared by a process, comprising (a) dissolving or dispersing an anti-inflammatory agent in a solvent and dissolving a biocompatible and biodegradable wall forming material in said solvent; (b) dispersing said solvent containing said a ...


4
Thomas R Tice, Richard M Gilley, John H Eldridge, Jay K Staas, Melinda G Hollingshead, William M Shannon: Method of potentiating an immune response. Southern Research Institute, UAB Research Foundation, Needle & Rosenberg, December 24, 1991: US05075109 (232 worldwide citation)

A method of delivering a bioactive agent to an animal entailing the steps of encapsulating effective amounts of the agent in a biocompatible excipient to form microcapsules having a size ranging from between approximately one micrometer to approximately ten micrometers and admnistering effective amo ...


5
John A Montgomery, John A Secrist III: 2-deoxy-4-thioribonucleosides and their antiviral activity. Southern Research Institute, Yahwak & Associates, January 7, 1997: US05591722 (214 worldwide citation)

2'-Deoxy-4'-thio-ribonucleosides, intermediates in their production, and their use as antiviral and anticancer agents are disclosed.


6
Joseph A Maddry, Robert C Reynolds, John A Secrist, John A Montgomery, Peter A Crooks: Polynucleotide analogs containing sulfonate and sulfonamide internucleoside linkages. Southern Research Institute, Jacobson Price Holman & Stern PLLC, October 1, 1996: US05561225 (211 worldwide citation)

The present invention provides for the preparation and use of ribo- and deoxyribo-nucleosides and polynucleotide analogs. The polynucleotide analogs are made of polynucleosides which contain sulfonate and sulfonamide linkages.


7
Thomas R Tice, Richard M Gilley: Microencapsulation process and products therefrom. Southern Research Institute, Needle & Rosenberg, April 18, 1995: US05407609 (193 worldwide citation)

A method of microencapsulating an agent to form a microencapsulated product, having the steps of dispersing an effective amount of the agent in a solvent containing a dissolved wall forming material to form a dispersion, combining the dispersion with an effective amount of a continuous process mediu ...


8
Thomas R Tice, William E Meyers, Richard M Gilley, William M Shannon: Long-acting biocidal compositions and method therefor. Southern Research Institute, Hopgood Calimafde Kalil Blaustein & Judlowe, April 29, 1986: US04585482 (120 worldwide citation)

There is disclosed, in one aspect, a long-acting biocidal composition. This composition comprises a chlorine dioxide-liberating compound, such as sodium chlorite, and sufficient organic acid-generating compound, such as poly(lactic acid), to lower the pH of the composition to less than about 7. The ...


9
Thomas R Tice, Danny H Lewis, Donald R Cowsar, Lee R Beck: Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents. The Stolle Research and Development Corporation, Southern Research Institute, Oblon Fisher Spivak McClelland & Maier, September 17, 1985: US04542025 (117 worldwide citation)

An anti-inflammatory agent containing microparticle composition prepared by a process, comprising (a) dissolving or dispersing an anti-inflammatory agent in a solvent and dissolving a biocompatible and biodegradable wall forming material in said solvent; (b) dispersing said solvent containing said a ...


10
Thomas R Tice, Richard M Gilley, John H Eldridge, Jay K Staas: Method for delivering bioactive agents into and through the mucosally-associated lymphoid tissues and controlling their release. Southern Research Institute, The UAB Research Foundation, Needle & Rosenberg, August 24, 1999: US05942252 (79 worldwide citation)

A method, and compositions for use therein capable, of delivering a bioactive agent to an animal entailing the steps of encapsulating effective amounts of the agent in a biocompatible excipient to form microcapsules having a size less than approximately ten micrometers and administering effective am ...



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