1
Robert M DeMarinis, Haralambos E Katerinopoulos, Katharine A Muirhead: Fluorescent intracellular calcium indicators. SmithKline Beckman Corporation, Stuart R Suter, Janice E Williams, Alan D Lourie, July 18, 1989: US04849362 (93 worldwide citation)

Invented are new tetracarboxylate compounds which are chelators for calcium ions. Also invented is a useful method of measuring intracellular calcium concentrations using these novel compounds as an optical indicator.


2
Brian G Bagnall, Robert J Gyurik: Delayed action assembly. SmithKline Beckman Corporation, William H Edgerton, Richard D Foggio, Alan D Lourie, January 14, 1986: US04564363 (90 worldwide citation)

A device for effecting the delayed release of an active ingredient comprises a container and, within, a dispersible unit of ingredient, a removable closure and a electrical control circuit for removal of said closure at a designated time to release the active ingredient. Several assemblies are combi ...


3
Josefina T Baker, Joseph F Pagano, Ronald J Schoengold: Method and device for collecting and testing for fecal occult blood. SmithKline Beckman Corporation, Joseph A Marlino, Stuart R Suter, Alan D Lourie, December 6, 1988: US04789629 (76 worldwide citation)

A method and slide for collecting and testing fecal occult blood which permits multiple analyses of a single fecal sample. The slide contains a pocket-like member on a portion of the inside front cover of the slide. An absorbent insert is disposed in the pocket. When the cover is in a closed positio ...


4
Paul E Bender, Don E Griswold, Nabil Hanna, Henry M Sarau: Inhibition of 5-lipoxygenase products. SmithKline Beckman Corporation, Nancy S Mayer, Stuart R Suter, Alan D Lourie, August 11, 1987: US04686231 (75 worldwide citation)

Novel compounds, compositions and pharmaceutical a method of inhibiting the 5-lipoxygenase pathway in an animal in need thereof which comprising administering an effective, 5-lipoxygenase pathway inhibiting amount of a 4,5-diaryl-2(substituted)-imidazole or a pharmaceutically acceptable salt thereof ...


5
Paul K Horan, Bruce D Jensen, Sue E Slezak: Viable cell labelling. SmithKline Beckman Corporation, Stuart R Suter, Alan D Lourie, Janice E Williams, November 8, 1988: US04783401 (48 worldwide citation)

Methods for reproducibly labelling viable cells with cyanine dyes that do not significantly affect cell viability. Applications for labelled cells include using labelled red blood cells to distinguish post-transfusional bleeding from immunologic reaction and using dilution to measure growth rate of ...


6
Paul K Horan, Sue E Slezak: In vivo cellular tracking. SmithKline Beckman Corporation, Vincent L Fabiano, Stuart R Suter, Alan D Lourie, August 9, 1988: US04762701 (47 worldwide citation)

Methods of tracking cells in vivo and for determining in vivo cell lifetimes. Cells are labelled with cyanine dyes and detection is by measuring fluorescence, absorbance, or by detecting nuclear magnetic resonance probes included in the cyanine dyes. Using the invented methods, for example, red bloo ...


7
Albert A Faulkner, John C Bouton: Slide carrier. SmithKline Beckman Corporation, Caesar Rivise Bernstein & Cohen, February 26, 1985: US04501495 (40 worldwide citation)

A system for transporting a tray holding at least one specimen slide to and from the microscope. The tray includes index marker means and engagement means. The system comprises an input station, indexing means at the microscope stage and an output station. The input station includes a hopper to rece ...


8
Dennis A Holt, Mark A Levy, Brian W Metcalf: Steroid 5-alpha-reductase inhibitors. SmithKline Beckman Corporation, Stuart R Suter, Alan D Lourie, March 20, 1990: US04910226 (40 worldwide citation)

Invented are substituted acrylate analogues of steroidal synthetic compounds, pharmaceutical compositions containing the compounds, and methods of using these compounds to inhibit steroid 5-.alpha.-reductase. Also invented are intermediates used in preparing these compounds.


9
Paul K Horan, Bruce D Jensen, Sue E Slezak: Cell growth rate determination by measurement of changes in cyanine dye levels in plasma membranes. SmithKline Beckman Corporation, Stuart R Suter, Alan D Lourie, August 22, 1989: US04859584 (37 worldwide citation)

Methods for determining growth rate of cells growing in vivo and in vitro. Cells are labelled with cyanine dyes and changes in plasma membrane cyanine dye levels are used to determine growth rate. Cell growth rate determinations are utilized to monitor transplanted bone marrow cell engraftment and p ...


10
Dennis A Holt, Mark A Levy, Brian W Metcalf: Phosphonic acid substituted aromatic steroids as inhibitors of steroid 5-.alpha.-reductase. SmithKline Beckman Corporation, Stuart R Suter, Alan D Lourie, November 21, 1989: US04882319 (37 worldwide citation)

Invented are phosphonic acid substituted analogues of steroidal synthetic compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds to inhibit steroid 5-.alpha.-reductase, including using these compounds to reduce or maintain prostate size. Also invented ...