1
Danishefsky Samuel J, Balog Aaron, Bertinato Peter, Su Dai Shi, Chou Ting Chao, Meng Dong Fang, Kamenecka Ted, Sorensen Erik J: Synthesis of epothilones, intermediates thereof, analogues and uses thereof. Sloan Kettering Institutefor C, February 4, 2004: EP1386922-A2 (8 worldwide citation)

The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof. Also provided are analogues related to epothilone A and B and intermediates useful for preparing same. The present invention further provides novel compositions bas ...


2
Cordon Cardo Carlos, Scher Howard I, Koff Andrew: Markers for prostate cancer. Sloan Kettering Institutefor C, March 9, 2005: EP1512755-A2 (6 worldwide citation)

This invention provides a method of treating prostate cancer in a subject comprising administering to the subject a therapeutically effective amount of anti-Her-2/neu antibody to the subject. This invention also provides a method of diagnosing prostate cancer in a subject which comprises: a) measuri ...


3
Bermudes David G, King Ivan Cheung Lam, Blasberg Ronald G, Tjuvajev Juri G: Non-invasive tumor imaging by tumor-targeted bacteria. Vion Pharmaceuticals, Sloan Kettering Institutefor C, May 6, 2004: EP1414499-A2

The present invention provides non-invasive compositions and methods to detect solid tumors using tumor-targeted bacteria. specifically, the present invention provides compositions and methods for detecting solid tumors in vivo by delivery of a marker gene to a solid tumor via a population of tumor- ...


4
Miesenbock Gero A, Zemelman Boris V: Heterologous stimulus-gated ion channels and methods of using same. Sloan Kettering Institutefor C, May 25, 2005: EP1532452-A2

Methods and compositions to activate a genetically designated target cell (or population of targetcells) artificially, in vivo or in vitro, employ triggering of heterologous stimulus-gated ion channels to activate the cells. The stimulus-gated ion channels are suitably TRPV1, TRPM8 or P2X2. A stimul ...


5
Sgouros George, Richon Victoria M, Marks Paul A, Rifkind Richard A: Combination therapy for the treatment of cancer. Sloan Kettering Institutefor C, February 2, 2005: EP1501489-A1

The present invention relates to a method for the treatment of cancer in a patient in need thereof. The method comprises administering to a patient in need thereof a first amount of a histone deacetylase inhibitor in a first treatment procedure, and a second amount or dose of radiation in a second t ...


6
Livingston Philip O, Helling Friedhelm: Ganglioside-klh conjugate vaccines with qs-21 for delaying recurrence of melanoma. Sloan Kettering Institutefor C, November 12, 2003: EP1360963-A2

This invention provides a vaccine for stimulating or enhancing the production of an antibody which recognizes a ganglioside in a subject to which the vaccine is administered. The vaccine is comprised of an amount of ganglioside or oligosaccharide portion thereof conjugated to an immunogenic protein ...


7
Richon Victoria, Zhou Xianbo, Rifkind Richard A, Marks Paul A: Hdac9 polypeptides and polynucleotides and uses thereof. Sloan Kettering Institutefor C, April 21, 2004: EP1409661-A2

The present invention features substantially pure HDAC9, HDAC9a, HDAC9([Delta]NLS), HDAC9a([Delta]NLS), an HDRP([Delta]NLS) polypeptides, and isolated nucleic acid molecules encoding those polypeptides. The present invention also features vectors containing HDAC9, HDAC9a, HDAC9([Delta]NLS, HDAC9a([D ...


8
Fong Yuman, Bennett Joseph, Petrowsky Henrik: Combination of a mutant herpes virus and irinotecan for the treatment of cancer. Sloan Kettering Institutefor C, February 23, 1999: EP1486212-A1

This invention provides methods of treating cancer employing attenuated mutant herpes viruses and irinotecan.


9
Richon Victoria M, Marks Paul A, Rifkind Richard A: Treatment of neurodegenerative diseases and cancer of the brain. Sloan Kettering Institutefor C, August 11, 2004: EP1443928-A2

The present application is directed to a method of inhibiting HDAC in the brain of a mammal. The method comprises administering to a mammal a HDAC inhibiting amount of a histone deacetylase inhibitor compound. The present application is further directed to a method of treating diseases of the centra ...


10
Cheung Nai Kong V, Guo Hong Fen: Method for preparation of single chain antibodies. Sloan Kettering Institutefor C, August 4, 2004: EP1441765-A2

This invention provides a method for identifying cells expressing a target single chain antibody (scFv) directed against a target antigen from a collection of cells that includes cells that do not express the target scFv, comprising the step of combining the collection of cells with an anti- idiotyp ...