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Mertelsmann Roland, Welte Karl, Venuta Salvatore: Purification of interleukin 2.. Sloan Kettering Inst Cancer, October 26, 1983: EP0092163-A2 (35 worldwide citation)

Interleukin 2 (IL 2; T-cell growth factor), produced with and without costimulation by Burkitt's lymphoma line Daudi, is purified approximately 37,000-fold to apparent homogeneity from lymphocyte-conditioned medium by (NH4)2SO4- precipitation, ion-exchange chromatography, gel filtration and hydropho ...


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Watanabe Kyoichi A, Chu Chung K, Fox Jack J: 2-fluoro-arabinofuranosyl purine nucleosides.. Sloan Kettering Inst Cancer, April 29, 1987: EP0219829-A2 (28 worldwide citation)

2 min -Deoxy-2 min -fluoro- beta -D-arabinofuranosyl nucleosides of the following structure are disclosed: wherein X and Y are the same or different and are hydrogen, OR, SR, NRR or NHacyl where R and R are the same or different and are hydrogen, lower alkyl of l to 7 carbon atoms, aralkyl, or acyl ...


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Old Lloyd J, Carswell Richards Elizabeth, Rubin Berish Y, Williamson Barbara D, Prendergast Jay S: Composition comprising purified human tumour necrosis factor in conjunction with human interferon and its use.. Sloan Kettering Inst Cancer, January 23, 1985: EP0131789-A2 (23 worldwide citation)

A method for the production and purification of human tumor necrosis factor (hTNF) is described. This purified material, shows growth inhibitory, hemorrhagic necrosis, cytotoxicity, and cytostasis effects on a variety of human tumors and cancers. The hTNF is free of exogeneous endotoxin, bacteria, a ...


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Lloyd Kenneth O, Yin Beatrice, Sakamoto Junichi, Watanabe Tadashi, Furukawa Koichi, Old Lloyd J: Monoclonal antibodies to human gastrointestinal cancer.. Sloan Kettering Inst Cancer, October 29, 1986: EP0199141-A2 (20 worldwide citation)

Diagnostic panels for human gastrointestinal abnormalities such as cancer using mouse monoclonal antibodies are disclosed. These panels can be used in diagnosis and in therapeutic applications such as colon cancer.


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Feickert Hans Joachim, Welte Karl, Mertelsmann Roland: Anti-interleukin-2 monoclonal antibodies.. Sloan Kettering Inst Cancer, June 20, 1984: EP0111344-A2 (18 worldwide citation)

Monoclonal antibodies recognizing interleukin-2 (IL-2) of various species (human, rat, mouse) are disclosed. These antibodies are useful in purification of IL-2 from biological sample as well as in separating IL-2 into various sub-species. Immunoassay of IL-2 and identification of cells containing I ...


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Israeli Ron S, Heston Warren D W, Fair William R: Prostate-specific membrane antigen. Sloan Kettering Inst Cancer, February 28, 2007: EP1757694-A2 (14 worldwide citation)

This invention provides for an isolated mammalian nucleic acid molecule encoding a mammalian prostate-specific membrane antigen. This invention provides for nucleic acid probes which specifically hybridize with the nucleic acid molecule encoding said antigen. This invention provides for a method of ...