1
Sih Charles J: Process for preparing l- carnitine and chemical intermediates employed therein. Sigma Tau Ind Farmaceuti, July 11, 1984: GB2132614-A (16 worldwide citation)

A process for preparing L- carnitine which comprises exposing gamma - substituted acetoacetic acid esters or amides to the fermentative enzymatic action of a microorganism which elaborates L- beta -hydroxyacyl CoA dehydrogenase [EC1.1.1.35], recovering the resulting, optically active, corresponding ...


2
Cavazza Claudio: Pharmaceutical compositions containing l-carnitine or derivatives thereof in combination with resveratrol or derivatives thereof, for the prophylaxis and treatment of cardiovascular disorders, peripheral vascular diseases and peripheral diabetic neuropathy. Sigma Tau Ind Farmaceuti, May 14, 1997: EP0773020-A2 (14 worldwide citation)

The co-ordinated therapeutic use of L-carnitine, lower alkanoyl L-carnitines or the pharmacologically acceptable salts thereof with resveratrol, resveratrol derivatives or resveratrol-containing natural products is disclosed for producing a medicament for the prophylaxis and treatment of cardiovascu ...


3
Tinti Maria Ornella, Misiti Domenico, Cavazza Claudio: Ester of l-carnitine with gamma-hydroxybutyric acid and pharmaceutical compositions containing it for inhibiting neuronal degeneration and for the treatment of coma.. Sigma Tau Ind Farmaceuti, May 29, 1991: EP0429403-A2 (14 worldwide citation)

The L-carnitine ester with gamma-hydroxybutyric acid and its pharmacologically accceptable salts of formula (I) wherein X is the anion of a pharmacologically acceptable salt, e.g. chloride, bromide, orotate, acid aspartate, acid citrate, acid phosphate, acid fumarate, lactate, acid maleate, acid oxa ...


4
Ghirardi Orlando, Cozzolino Roberto, Giannessi Fabio, Misiti Domenico, Tinti Maria Ornella, Scolastico Carlo: Pharmaceutical compositions comprising 3-amino-epsilon-caprolactames for enhancing learning and memory.. Sigma Tau Ind Farmaceuti, December 27, 1991: EP0462948-A2 (13 worldwide citation)

Pharmaceutical compositions for enhancing the process of learning and memory are disclosed, that contain as active principle a 3-amino- epsilon -caprolactam of formula (1) Wherein R is selected from the group consisting of hydrogen, formyl and acetyl. Orally or parenterally administrable pharmaceuti ...


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Calvani Menotti, Cavazza Claudio: Pharmaceutical composition comprising l-carnitine or an alkanoyl l-carnitine in combination with a polyunsaturated fatty acid of the omega-3 series for the prevention and the treatment of lipid metabolism disorders. Sigma Tau Ind Farmaceuti, June 25, 1997: EP0780124-A1 (11 worldwide citation)

A novel therapeutic use of L-carnitine or alkanoyl L-carnitine is disclosed in combination with a polyunsaturated fatty acid of the omega-3 series, for the prevention and the treatment of lipid metabolism disorders and cardiovascular disorders.


7
Calvani Menotti, Carta Angelico: Use of acetyl-l-carnitine for the treatment of presenile alzheimers disease. Sigma Tau Ind Farmaceuti, November 26, 1997: EP0808626-A1 (11 worldwide citation)

The use of acetyl L-carnitine and the pharmacologically acceptable salts thereof is disclosed for producing a medicament selectively suitable for slowing down the worsening of the symptoms in patients affected from the presenile form of Alzheimer @ s disease (AD) ( @ early-onset @ AD patients).


8
Tinti Maria Ornella, Misiti Domenico, Cavazza Claudio, Scafetta Nazareno: Esters of acyl l-carnitines with gamma-hydroxybutyric acid and pharmaceutical compositions containing them for inhibiting neuronal degeneration and for the treatment of coma.. Sigma Tau Ind Farmaceuti, August 21, 1991: EP0442850-A1 (11 worldwide citation)

The esters of acyl L-carnitines with gamma-hydroxybutyric acid in the form of pharmacologically acceptable salts of formula (I) wherein X is the anion of a pharmacologically acceptable salt, e.g. chloride, bromide, orotate, acid aspartate, acid citrate, acid phosphate, acid fumarate, lactate, acid m ...


9
Scafetta Nazareno, Santaniello Mose, Tinti Maria Ornella, Misiti Domenico, Stasi Maria Antonietta, Vesci Loredana, Corsico Nerima: Esters of l-carnitine and acyl l-carnitine endowed with muscle relaxant activityselective on gastrointestinal tract and pharmaceutical compositions containing same.. Sigma Tau Ind Farmaceuti, September 8, 1993: EP0559625-A2 (11 worldwide citation)

Esters of L-carnitine and acyl L-carnitine of formula (I): wherein R is hydrogen or is a straight or branched, saturated or unsaturated acyl group having 2 to 26 carbon atoms; R1 is a straight or branched, saturated or unsaturated alkyl group having 4 to 26 carbon atoms; and X is the anion of a phar ...


10
Tinti Maria Ornella, Scafetta Nazareno, Misiti Domenico: Esters of (r)(-)-carnitine and acyl (r)(-)-carnitines with beta-hydroxybutyric acid and pharmaceutical compositions containing them for inhibiting neuronal degeneration, liver proteolysis and for the treatment of coma.. Sigma Tau Ind Farmaceuti, August 28, 1991: EP0443996-A1 (11 worldwide citation)

The esters of (R)(-)-carnitine and acyl (R)(-)-carnitines with beta-hydroxybutiric acid in the form of pharmacologically acceptable salts of formula (I) wherein X is the anion of a pharmacologically acceptable salt, e.g. chloride, bromide, orotate, acid aspartate, acid citrate, acid phosphate, acid ...