1
Nicholas D Cosford, Jean Michel Vernier: Substituted pyridines useful as modulators of acethylcholine receptors. SIBIA Neurosciences, Stephen E Gray Care Ware & Freidenrich Reiter, December 22, 1998: US05852041 (92 worldwide citation)

In accordance with the present invention, there provided a class of pyridine compounds which are modulators of acetylcholine receptors. The compounds of the invention displace acetylcholine receptor ligands from their binding sites. Invention compounds may act as agonists, partial agonists, antagoni ...


2
Michael Anthony Akong, Michael Miller Harpold, Gonul Velicelebi, Paul Brust: Automated analysis equipment and assay method for detecting cell surface protein and/or cytoplasmic receptor function using same. SIBIA Neurosciences, Stephanie L Brown Martin Haller & McClain Seidman, September 23, 1997: US05670113 (76 worldwide citation)

Automated measurement apparatus and methods for automated drug screening and for studying ion channel and cell surface receptor activity are provided. The apparatus is designed to initiate and measure rapid or transient events, such as cell receptor and/or ion channel activity. The apparatus can eff ...


3
Michael Anthony Akong, Michael Miller Harpold, Gonul Velicelebi, Paul Brust: Automated assays and methods for detecting and modulating cell surface protein function. Sibia Neurosciences, Stephanie L Heller Ehrman White & McAuliffe Seidman, May 2, 2000: US06057114 (71 worldwide citation)

Automated assays for detecting and measuring ion channel and cell surface receptor activity and for identifying compounds that modulate or potentiate such activity are provided. Among the assays are fluorescent indicator-based assays that use cells containing effective levels of a fluorescent indica ...


4
Nicholas D Cosford, Jean Michel Vernier: Substituted pyridines useful as modulators of acetylcholine receptors. Sibia Neurosciences, Stephen E Reiter, Pretty Schroeder Brueggemann & Clark, December 17, 1996: US05585388 (26 worldwide citation)

In accordance with the present invention, there is provided a class of pyridine compounds which are modulators of acetylcholine receptors. The compounds of the invention displace acetylcholine receptor ligands from their binding sites. Invention compounds may act as agonists, partial agonists, antag ...


5
Ian A McDonald, Jeffrey P Whitten, Nicholas D Cosford: Modulators of acetylcholine receptors. Sibia Neurosciences, Stephen E Gray Cary Ware & Freidenrich Reiter, March 3, 1998: US05723477 (22 worldwide citation)

The present invention provides a class of pyridine compounds which are modulators of acetylcholine receptors, i.e., compounds which displace acetylcholine receptor ligands from their binding sites. Invention compounds may act as agonists, partial agonists, antagonists or allosteric modulators of ace ...


6
Nicholas D Cosford, Jean Michel Vernier: Substituted pyridines useful as modulators of acetylcholine receptors. SIBIA Neurosciences, Stephen E Gary Cary Ware & Freidenrich Reiter, April 7, 1998: US05736560 (21 worldwide citation)

In accordance with the present invention, there is provided a class of pyridine compounds which are modulators of acetylcholine receptors. The compounds of the invention displace acetylcholine receptor ligands from their binding sites. Invention compounds may act as agonists, partial agonists, antag ...


7
Ian A McDonald, Jeffrey P Whitten, Nicholas D Cosford: Modulators of acetylcholine receptors. SIBIA Neurosciences, Stephen E Gray Cary Ware & Freidenrich Reiter, December 30, 1997: US05703100 (20 worldwide citation)

In accordance with the present invention, there is provided a class of pyridine compounds which are modulators of acetylcholine receptors. The compounds of the invention displace acetylcholine receptor ligands from their binding sites. Invention compounds may act as agonists, partial agonists, antag ...


8
Ian A McDonald, Jeffrey P Whitten, Nicholas D Cosford: Modulators of acetylcholine receptors. SIBIA Neurosciences, Stephen E Reiter, Pretty Schroeder Brueggemann & Clark, January 14, 1997: US05594011 (20 worldwide citation)

In accordance with the present invention, there is provided a class of pyridine compounds which are modulators of acetylcholine receptors. The compounds of the invention displace acetylcholine receptor ligands from their binding sites. Invention compounds may act as agonists, partial agonists, antag ...


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