1
Shirai Junya, Matsumoto Takahiro, Kamo Izumi: (Ja) ベンゾオキサゼピン誘導体およびその用途, (En) Benzoxazepine derivatives and use thereof. Takeda Pharmaceutical Company, Shirai Junya, Matsumoto Takahiro, Kamo Izumi, TAKASHIMA Hajime, September 12, 2008: WO/2008/108445 (19 worldwide citation)

(EN) Compounds represented by the general formula (I) wherein each symbol is as defined in the description [with the proviso that 9-chloro-7-(1,1-dimethylethyl)-2,3,4,5-tetrahydro-1,4-benz-oxazepine and N-[[(5S)-2-oxo-3-(2,3,4,5-tetrahydro-1,4- benz- oxazepin-7-yl)-5-oxazolidinyl]methyl]acetamide ar ...


2
Ikeura Yoshinori, Shirai Junya, Sugiyama Hideyuki, Nishikimi Yuji, Kamei Taku, Sakauchi Nobuki: Nitrogen-containing heterocyclic compound and use thereof. Takeda Pharmaceutical Company, Ikeura Yoshinori, Shirai Junya, Sugiyama Hideyuki, Nishikimi Yuji, Kamei Taku, Sakauchi Nobuki, TAKASHIMA Hajime, June 11, 2009: WO/2009/072643 (11 worldwide citation)

The present invention relates to a compound represented by the formula wherein ring A is a nitrogen-containing heterocycle optionally further having substituent(s), ring B is an aromatic ring optionally having substituent(s), ring C is a cyclic group optionally having substituent(s), R1 is a hydroge ...


3
Shirai Junya, Kusumoto Tomokazu, Nagamiya Hiroyuki, Kamo Izumi: (Ja) 縮合複素環化合物およびその用途, (En) Fused heterocyclic compound and use thereof. Takeda Pharmaceutical Company, Shirai Junya, Kusumoto Tomokazu, Nagamiya Hiroyuki, Kamo Izumi, TAKASHIMA Hajime, November 22, 2007: WO/2007/132841 (7 worldwide citation)

(EN) Disclosed is a serotonin 5-HT2C receptor activator comprising a compound represented by the formula below or a salt or prodrug thereof: (I) wherein the ring A represents a 5- or 6-membered aromatic heterocyclic ring which may have a substituent; and the ring B represents a 7- to 9-membered ring ...


4
YAMAMOTO Satoshi, SHIRAI Junya, OCHIDA Atsuko, FUKASE Yoshiyuki, TOMATA Yoshihide, SATO Ayumu, MIURA Shotaro, YONEMORI Kazuko, KOYAMA Ryokichi: [ja] 複素環化合物, [fr] COMPOSÉ HÉTÉROCYCLIQUE, [en] HETEROCYCLIC COMPOUND. YAMAMOTO Satoshi, SHIRAI Junya, OCHIDA Atsuko, FUKASE Yoshiyuki, TOMATA Yoshihide, SATO Ayumu, MIURA Shotaro, YONEMORI Kazuko, KOYAMA Ryokichi, TAKEDA PHARMACEUTICAL COMPANY, TAKASHIMA Hajime, February 7, 2013: WO/2013/018695 (7 worldwide citation)

[en] To provide a heterocyclic compound which has an RORγt inhibitory effect. A compound represented by formula (I) or a salt thereof. (In the formula, ring A represents an optionally substituted cyclic group; Q represents a bonding hand or the like; R1 represents a substituent; ring B represents a ...


5
Matsumoto Takahiro, Nagamiya Hiroyuki, Shirai Junya, Kusumoto Tomokazu: (Ja) 縮合ピリジン誘導体およびその用途, (En) Fused pyridine derivative and use thereof. Takeda Pharmaceutical Company, Matsumoto Takahiro, Nagamiya Hiroyuki, Shirai Junya, Kusumoto Tomokazu, TAKASHIMA Hajime, May 22, 2009: WO/2009/063993 (5 worldwide citation)

(EN) Disclosed is a serotonin 5-HT2c receptor activator containing a compound represented by the formula (I) below or a salt thereof. (In the formula, the symbols are as defined in the description.)(JA)  本発明は、式:[式中、各記号は明細書中と同義を示す]で表される化合物またはその塩を含有してなるセロトニン5-HT2c受容体活性化剤に関する。


6
Ikeura Yoshinori, Hashimoto Tadatoshi, Nishida Haruyuki, Shirai Junya, Sakauchi Nobuki: (Ja) ピペリジン誘導体およびその用途, (En) Piperidine derivatives and use thereof. Takeda Pharmaceutical Company, Ikeura Yoshinori, Hashimoto Tadatoshi, Nishida Haruyuki, Shirai Junya, Sakauchi Nobuki, TAKASHIMA Hajime, March 23, 2006: WO/2006/030975 (2 worldwide citation)

(EN) Compounds represented by the general formula (&Igr;) or salts thereof; and preventive and therapeutic drugs for lower urinary tract dysfunction and so on, containing the compounds or the salts: wherein Ar is optionally substituted aryl; R is C1-6 alkyl; R1 is hydrogen, an optionally substituted ...


7
Ikeura Yoshinori, Hashimoto Tadatoshi, Tarui Naoki, Kamo Izumi, Shirai Junya: Tricyclic heterocyclic compound, process for producing the same, and use thereof. Takeda Chemical Industries, Ikeura Yoshinori, Hashimoto Tadatoshi, Tarui Naoki, Kamo Izumi, Shirai Junya, TAKASHIMA Hajime, March 21, 2002: WO/2002/022574 (1 worldwide citation)

A compound represented by the formula, a salt thereof, or a prodrug thereof: (I) wherein R?1¿ represents hydrogen, optionally substituted alkyl, aryl, acyl, alkoxycarbonyl, carbamoyl, mono- or dialkylcarbamoyl, or alkylsulfonyl; R?2¿ represents hydrogen, halogeno, or optionally halogenated alkyl; R? ...


8
Shirai Junya, Morimoto Shinji, Sugiyama Hideyuki, Sakauchi Nobuki, Yoshikawa Takeshi: Piperidine derivative and use thereof. Takeda Pharmaceutical Company, Shirai Junya, Morimoto Shinji, Sugiyama Hideyuki, Sakauchi Nobuki, Yoshikawa Takeshi, TAKASHIMA Hajime, November 6, 2008: WO/2008/133344 (1 worldwide citation)

The present invention provides a novel piperidine derivative and a tachykinin receptor antagonist containing same, as well as a compound represented by the formula (I) wherein R1 is carbamoylmethyl, methylsulfonylethylcarbonyl and the like; R2 is methyl or cyclopropyl; R3 is a hydrogen atom or methy ...


9
Shirai Junya, Yoshikawa Takeshi, Sugiyama Hideyuki: Piperidine derivatives as tachykinin receptor antagonists. Takeda Pharmaceutical Company, Shirai Junya, Yoshikawa Takeshi, Sugiyama Hideyuki, TAKASHIMA Hajime, August 9, 2007: WO/2007/089031 (1 worldwide citation)

A novel piperidine derivative represented by the formula (I) (I) wherein Ar is a phenyl group optionally having substituent(s), R¿1? is a hydrogen atom, a hydrocarbon group optionally having substituent(s), an acyl group or a heterocyclic group optionally having substituent(s), Z is a methylene grou ...


10
Ikeura Yoshinori, Shirai Junya: (Ja) カルボキサミド誘導体およびその用途, (En) Carboxamide derivative and use thereof. Takeda Pharmaceutical Company, Ikeura Yoshinori, Shirai Junya, TAKASHIMA Hajime, July 28, 2005: WO/2005/068427

(EN) A compound represented by the formula (I) (wherein ring A represents an optionally further substituted nitrogenous heterocycle; rings B and C each represents an optionally substituted aromatic ring; R1 represents hydrogen, an optionally substituted hydrocarbon group, acyl, or an optionally subs ...