1
Hayase Yoshio, Kataoka Takahiro, Takenaka Hideyuki, Ichinari Mitsuhiro, Masuko Michio, Takahashi Toshio, Tanimoto Norihiko: Alkoxyiminoacetamide derivatives and their use as fungicides.. Shionogi & Co, November 22, 1990: EP0398692-A2 (175 worldwide citation)

A fungicidal composition for agricultural use, which comprises a compound of the formula: wherein R and R are each hydrogen, lower alkyl or cyclo(lower)alkyl; R is lower alkyl or cyclo(lower)alkyl; R and R are each hydrogen, lower alkyl, lower alkoxy, halogen-substituted lower alkyl, lower alkyl-sub ...


2
Kentaro Hirai, Teruyuki Ishiba, Haruo Koike, Masamichi Watanabe: Pyrimidine derivatives. Shionogi Seiyaku Kabushiki Kaisha, Wenderoth Lind & Ponack, November 9, 1993: US05260440 (167 worldwide citation)

The compounds of the present invention inhibit the HMG-CoA reductase, and subsequently suppress the biosynthesis of cholesterol. And they are useful in the treatment of hypercholesterolemia, hyperlipoproteinemia, and atherosclerosis.


3
Toyoda Tatsuo, Fujioka Toshihiro, Hayashi Kunio, Nakamura Masuhisa, Hashimoto Naofumi: Renin inhibiting dipeptide derivatives, their preparation and pharmaceutical preparations containing them.. Shionogi & Co, January 29, 1992: EP0468641-A2 (109 worldwide citation)

A novel dipeptide derivative of the following formula (I), which compound is capable of inhibiting the enzymatic activity of renin and thereby depressing the renin-angiotensin system and lowering the blood pressure, is provided. wherein: R is C1-C12 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C10 cycloa ...


4
Hirai Kentaro, Ishiba Teruyuki, Koike Haruo, Watanabe Masamichi: Pyrimidine derivatives as hmg-coa reductase inhibitors.. Shionogi & Co, January 7, 1993: EP0521471-A1 (107 worldwide citation)

The compounds of the present invention inhibit the HMG-CoA reductase, and subsequently suppress the biosynthesis of cholesterol. And they are useful in the treatment of hypercholesterolemia, hyperlipoproteinemia, and atherosclerosis.


5
Shudo Koichi Accommodation For: Carboxylic acid derivatives having retinoic acid-like activity.. Shudo Koichi, Shionogi & Co, September 28, 1994: EP0617020-A1 (87 worldwide citation)

Carboxylic acid derivatives having potent retinoid-type pharmacological activities are disclosed. The compounds disclosed are represented by the following formula: wherein R, R, and R independently represent a hydrogen atom or an alkyl group with the exception that all of R, R, and R do not simultan ...


6
Kobayashi Naotake, Ueda Kazuo, Itoh Naohiro, Suzuki Shinji, Sakaguchi Gaku, Kato Akira, Yukimasa Akira, Hori Akihiro, Koriyama Yuji, Haraguchi Hidekazu, Yasui Ken, Kanda Yasuhiko: Aminodihydrothiazine derivative. Shionogi & Co, July 9, 2008: EP1942105-A1 (86 worldwide citation)

A composition having BACE 1 inhibitory activity containing a compound represented by the general formula (I): wherein ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; E is lower alkylene; X is S, O, or NR 1 ; R 1 is a hydrogen atom or lower alkyl ...


7
Kobayashi Naotake, Ueda Kazuo, Itoh Naohiro, Suzuki Shinji, Sakaguchi Gaku, Kato Akira, Yukimasa Akira, Hori Akihiro, Kooriyama Yuji, Haraguchi Hidekazu, Yasui Ken, Kanda Yasuhiko: (Ja) アルツハイマー症治療用医薬組成物, (En) Pharmaceutical composition for treatment of alzheimers disease. Shionogi &, Kobayashi Naotake, Ueda Kazuo, Itoh Naohiro, Suzuki Shinji, Sakaguchi Gaku, Kato Akira, Yukimasa Akira, Hori Akihiro, Kooriyama Yuji, Haraguchi Hidekazu, Yasui Ken, Kanda Yasuhiko, TAKAYAMA Hirotsugu, November 6, 2008: WO/2008/133273 (85 worldwide citation)

(EN) Disclosed is a pharmaceutical composition for treatment of Alzheimer's disease, which contains a compound represented by the formula (I) below, a pharmaceutically acceptable salt thereof, or a solvate of any of them as an active ingredient. (I) (In the formula, ring A represents an optionally s ...


8
Tamura Yuusuke, Suzuki Shinji, Tada Yukio, Yonezawa Shuji, Fujikoshi Chiaki, Matsumoto Sae, Kooriyama Yuuji, Ueno Tatsuhiko: (Ja) 環式基で置換されたアミノジヒドロチアジン誘導体, (En) Aminodihydrothiazine derivatives substituted with cyclic groups. Shionogi &, Tamura Yuusuke, Suzuki Shinji, Tada Yukio, Yonezawa Shuji, Fujikoshi Chiaki, Matsumoto Sae, Kooriyama Yuuji, Ueno Tatsuhiko, TANAKA Mitsuo, November 6, 2008: WO/2008/133274 (83 worldwide citation)

(EN) The invention provides compounds represented by the general formula (I) which are useful as remedies for diseases induced by the production, secretion, or deposition of amyloid β protein. Compounds represented by the general formula (I); pharmaceutically acceptable salts thereof; or solvates of ...


9
Kenji Mitsushima, Akio Takimoto, Shigeo Yaqi, Takayasu Sonoyama: Cephalosporin acetylhydrolase gene and protein encoded by said gene. Shionogi &, Birch Stewart Kolasch & Birch, August 16, 1994: US05338676 (81 worldwide citation)

A cephalosporin acetylhydrolase gene, a recombinant DNA molecule prepared by introducing said gene into a vector used in an E. coli host-vector system, E. coli cells transfomed with said recombinant DNA molecule, a protein having the amino acid sequence encoded by said gene, an enzyme which is a mul ...


10
Maekawa Hideyuki, Nakanishi Masaichi: Compartmentalized container. Shionogi &, Stewart and Kolasch, December 24, 1974: US3856138 (79 worldwide citation)

A compartmentalized container for storing, mixing and dispensing a plurality of incompatible liquids which must be segregated prior to use, which container includes in combination; an outer and an inner cylindrical side wall components, a bottom plug and a closure cap means with a sealing member.Eac ...