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Mario Contorni, Derek O hagan, Nicola Groth: Influenza vaccines with reduced amounts of squalene. Seqirus, Morrison & Foerster, March 8, 2016: US09278126

Influenza vaccines include hemagglutinin from at least one influenza A virus strain and at least one influenza B virus strain. They also include an oil-in-water emulsion adjuvant with submicron oil droplets, comprising squalene. In some embodiments the hemagglutinin concentration is >12 μg/ml per st ...


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Audino Podda, Nicola Groth, Michele Pellegrini: Adjuvanted influenza vaccines for pediatric use. Seqirus, Finnegan Henderson Farabow Garrett & Dunner, February 14, 2017: US09566326

An influenza vaccine adjuvanted with a sub-micron oil-in-water emulsion elicits significantly higher immune responses in human pediatric populations. Compared to an existing unadjuvanted pediatric influenza vaccine, the adjuvanted vaccines provided herein can induce in children a longer persistence ...


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Derek O Hagan: Influenza vaccination. Seqirus, Finnegan Henderson Farabow Garrett & Dunner, October 30, 2018: US10112979

Influenza viruses have traditionally been administered by intramuscular injection. The invention is based on the idea of using alternative routes of delivery for influenza vaccines, more specifically routes that do not require as large a dose of antigen. Delivery of influenza antigen to the Langerha ...


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Derek O Hagan, Manmohan Singh, Sung Yun Kwon: Soluble needle arrays for delivery of influenza vaccines. Seqirus, Finnegan Henderson Farabow Garrett & Dunner, December 13, 2016: US09517205

Influenza vaccines are administered using solid biodegradable microneedles. The microneedles are fabricated from the influenza vaccine in combination with solid excipient(s) and, after penetrating the skin, they dissolve in situ and release the vaccine to the immune system. The influenza vaccine is ...


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INFLUENZA VACCINES WITH REDUCED AMOUNTS OF SQUALENE. Seqirus, August 18, 2016: US20160235835-A1

Influenza vaccines include hemagglutinin from at least one influenza A virus strain and at least one influenza B virus strain. They also include an oil-in-water emulsion adjuvant with submicron oil droplets, comprising squalene. In some embodiments the hemagglutinin concentration is >12 μg/ml per st ...


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TSAI THEODORE F: VACCINS COMPRENANT UN ANTIGENE ISSU DE QUATRE SOUCHES DU VIRUS GRIPPAL, VACCINES INCLUDING ANTIGEN FROM FOUR STRAINS OF INFLUENZA VIRUS. Novartis, SEQIRUS, BORDEN LADNER GERVAIS, August 15, 2017: CA2671629

Vaccines of the invention include at least four influenza virus strains. In some embodiments, the vaccines are produced in cell culture rather than in eggs. In some embodiments, the vaccines include an adjuvant. In some embodiments, the vaccines are not split or whole virion vaccines, but are live o ...


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TRUSHEIM HEIDI, MASON PETER, FRANTI MICHAEL, KEINER BJOERN, SACKAL MELISSA, HUNZIKER JUERG, MORRISSEY DAVID, NATT FRANCOIS JEAN CHARLES: PROCEDE DE REARRANGEMENT DES GENES DU VIRUS GRIPPAL, INFLUENZA VIRUS REASSORTMENT METHOD. Novartis, SEQIRUS, BORDEN LADNER GERVAIS, September 4, 2018: CA2800150

Methods for producing reassortant viruses are provided wherein the transcription and/or translation of the hemagglutinin and/or neuraminidase genes are suppressed.