1
Stephen L Monfre, Kevin H Hazen, Timothy L Ruchti, Thomas B Blank, James R Henderson: Method and apparatus using alternative site glucose determinations to calibrate and maintain noninvasive and implantable analyzers. Sensys Medical, Michael A Glenn, Glenn Patent Group, February 14, 2006: US06998247 (626 worldwide citation)

Methods for calibrating noninvasive or implantable glucose analyzers utilize either alternative invasive glucose determinations or noninvasive glucose determinations for calibrating noninvasive or implantable glucose analyzers. Use of an alternative invasive or noninvasive glucose determination in t ...


2
George M Acosta, James R Henderson, N Alan Abul Haj, Timothy L Ruchti, Stephen L Monfre, Thomas B Blank, Kevin H Hazen: Compact apparatus for noninvasive measurement of glucose through near-infrared spectroscopy. Sensys Medical, Michael A Glenn, Glenn Patent Group, November 7, 2006: US07133710 (325 worldwide citation)

The invention involves the monitoring of a biological parameter through a compact analyzer. The preferred apparatus is a spectrometer based system that is attached continuously or semi-continuously to a human subject and collects spectral measurements that are used to determine a biological paramete ...


3
Stephen L Monfre, Kevin H Hazen, Timothy L Ruchti, Thomas B Blank, James R Henderson: Apparatus using reference measurement for calibration. Sensys Medical, Michael A Glenn, Glenn Patent Group, February 27, 2007: US07183102 (278 worldwide citation)

A method and apparatus for calibrating noninvasive or implantable glucose analyzers that uses either alternative invasive glucose determinations or noninvasive glucose determinations to calibrate noninvasive or implantable glucose analyzers. Use of an alternative invasive or noninvasive glucose dete ...


4
Alexander D Lorenz, Timothy L Ruchti: Method of adapting in-vitro models to aid in noninvasive glucose determination. Sensys Medical, Michael A Glenn, Glenn Patent Group, January 8, 2008: US07317938 (229 worldwide citation)

The invention relates to a noninvasive analyzer and a method of using information determined at least in part from in-vitro spectra of tissue phantoms or analyte solutions to aid in the development of a noninvasive glucose concentration analyzer and/or in the analysis of noninvasive spectra resultin ...


5
George Acosta, James R Henderson, N Alan Abul Haj, Timothy L Ruchti, Stephen L Monfre, Thomas B Blank, Kevin H Hazen: Compact apparatus for noninvasive measurement of glucose through near-infrared spectroscopy. Sensys Medical, Michael A Glenn, Glenn Patent Group, November 20, 2007: US07299080 (214 worldwide citation)

A near IR spectrometer-based analyzer attaches continuously or semi-continuously to a human subject and collects spectral measurements for determining a biological parameter in the sampled tissue, such as glucose concentration. The analyzer includes an optical system optimized to target the cutaneou ...


6
Thomas B Blank, Stephen L Monfre, Timothy L Ruchti, Suresh Thennadil: Multi-tier method of developing localized calibration models for non-invasive blood analyte prediction. Sensys Medical, Michael A Glenn, Chris Peil, January 28, 2003: US06512937 (145 worldwide citation)

A method of multi-tier classification and calibration in noninvasive blood analyte prediction minimizes prediction error by limiting co-varying spectral interferents. Tissue samples are categorized based on subject demographic and instrumental skin measurements, including in vivo near-IR spectral me ...


7
Thomas B Blank, George Acosta, Mutua Mattu, Marcy Makarewicz, Stephen L Monfre, Alexander D Lorenz, Timothy L Ruchti: Optical sampling interface system for in vivo measurement of tissue. Sensys Medical, Michael A Glenn, Glenn Patent Group, June 19, 2007: US07233816 (140 worldwide citation)

An optical sampling interface system minimizes and compensates error resulting from sampling variations and measurement site state fluctuations. Components include: An optical probe placement guide having an aperture wherein the optical probe is received, facilitates repeatable placement accuracy on ...


8
Linda Hockersmith, Thomas B Blank, Stephen L Monfre, Timothy L Ruchti: Use of targeted glycemic profiles in the calibration of a noninvasive blood glucose monitor. Sensys Medical, Michael A Glenn, Christopher Peil, November 26, 2002: US06487429 (139 worldwide citation)

A method of calibrating a non-invasive blood glucose measurement instrument to a diabetic test subject employs targeted glycemic profiles in anti-correlated pairs. During calibration, reference blood glucose determinations are made using conventional invasive sampling methods. Concurrently, noninvas ...


9
Thomas B Blank, George Acosta, Mutua Mattu, Marcy Makarewicz, Stephen L Monfre, Alexander D Lorenz, Timothy L Ruchti: Optical sampling interface system for in vivo measurement of tissue. Sensys Medical, Michael A Glenn, Glenn Patent Group, April 17, 2007: US07206623 (120 worldwide citation)

An optical sampling interface system minimizes and compensates error resulting from sampling variations and measurement site state fluctuations. Components include: An optical probe placement guide having an aperture wherein the optical probe is received, facilitates repeatable placement accuracy on ...


10
Stephen L Monfre, Thomas B Blank, Timothy L Ruchti, Suresh Thennadil: Multi-tier method of classifying sample spectra for non-invasive blood analyte prediction. Sensys Medical, Michael A Glenn, Chris Peil, January 28, 2003: US06512936 (77 worldwide citation)

A method of multi-tier classification and calibration in noninvasive blood analyte prediction minimizes prediction error by limiting co-varying spectral interferents. Tissue samples are categorized based on subject demographic and instrumental skin measurements, including in vivo near-IR spectral me ...