1
Barbara Cordell: Transgenic mice displaying the amyloid-forming pathology of alzheimers disease. Scios Nova, Morrison & Foerster, February 7, 1995: US05387742 (190 worldwide citation)

Cloned recombinant or synthetic DNA sequences related to the pathology of Alzheimer's disease are injected into fertilized mouse eggs. The injected eggs are implanted in pseudo pregnant females and are grown to term to provide transgenic mice whose cells express proteins related to the pathology of ...


2
Edmund G Tischer, Judith A Abraham, John C Fiddes, Richard L Mitchell: DNA sequences encoding bVEGF120 and hVEGF121 and methods for the production of bovine and human vascular endothelial cell growth factors, bVEGF.sub.120 and hVEGF.sub.121. Scios Nova, Peter R Shearer, June 15, 1993: US05219739 (99 worldwide citation)

Isolated DNA sequences, expression vectors and transformant cells are provided which allow for the large scale production of vascular endothelial cell growth factor. The vascular endothelial cell growth factor is useful in the treatment of wounds in which neovascularization or reendothelialization i ...


3
Barbara Cordell, James W Schilling, Nobuhiko Katunuma: Methods of treatment using Alzheimers amyloid polypeptide derivatives. Scios Nova, Morrison & Foerster, February 16, 1993: US05187153 (62 worldwide citation)

Pharmaceutical compositions containing a 57 amino acid protease inhibitor and uses for those compositions are taught. The protease inhibitor is referred to as A4i which is associated with Alzheimer's disease. In addition to the A4i protease, other analogs are taught as are pharmaceutical composition ...


4
Phyllis A Ponte, Barbara Cordell: DNA sequence useful for the detection of Alzheimers disease. Scios Nova, Morrison & Foerster, June 15, 1993: US05220013 (60 worldwide citation)

DNA sequences encoding the beta-amyloid core protein, and beta-amyloid-related proteins associated with Alzheimer's disease are disclosed. These sequences are used in producing or constructing recombinant beta-amyloid core protein, beta-amyloid-related proteins and recombinant or synthetic immunogen ...


5
John C Fiddes, Judith A Abraham: DNA encoding human recombinant basic fibroblast growth factor. Scios Nova, Burns Doane Swecker & Mathis, August 8, 1995: US05439818 (39 worldwide citation)

Disclosed herein are the DNA sequences encoding human and bovine acidic and basic fibroblast growth factors (FGF). Expression of these sequences results in practical amounts of proteins useful in effecting wound healing.


6
S Joseph Tarnowski, Sandra Hilliker, W Scott Willett: Expression of recombinant polypeptides with improved purification. Scios Nova, Morrison & Foerster, June 21, 1994: US05322930 (36 worldwide citation)

An improved method for expressing peptides as fusion proteins, uses a carrier for a heterologous peptide to provide a fusion protein having a high pI. The high isoelectric point facilitates separation of the fusion protein from all other host cell proteins, and separation of the carrier from the pep ...


7
Linda Foster, Stewart A Thompson, S Joseph Tarnowski: Formulations for stabilizing fibroblast growth factor. Scios Nova, Morrison & Foerster, June 8, 1993: US05217954 (35 worldwide citation)

Pharmaceutical formulations and a method for their preparation are provided. These formulations provide a stabilized basic fibroblast growth factor (bFGF) which is less susceptible to oxidation or metal-induced aggregation by including an amount of a chelating agent effective to stabilize the bFGF.


8
Barbara Cordell, David Wolf: Assays and reagents for amyloid deposition. Scios Nova, Morrison & Foerster, June 22, 1993: US05221607 (34 worldwide citation)

The present invention provides an in vitro tissue culture-based assay for amyloid deposition specific for Alzheimer's disease which is suitable for routine drug screening analysis. Immunological diagnostic reagents for Alzheimer's disease are also provided.


9
John A Lewicki, Robert M Scarborough Jr: Atrial Natriuretic/vasodilator peptide compounds. Scios Nova, Morrison & Foerster, May 18, 1993: US05212286 (32 worldwide citation)

Methods, compounds and compositions are provided for inducing natriuresis, diuresis and vasodilatation in mammalian hosts by administering atrial natriuretic/vasodilator peptides to said host. Also provided are methods for producing such peptide compounds.


10
James W Schilling Jr, Phyllis A Ponte, Barbara Cordell: Recombinant Alzheimers protease inhibitory amyloid protein and method of use. Scios Nova, Karl Bozicevic, June 29, 1993: US05223482 (30 worldwide citation)

DNA sequences encoding .beta.-amyloid-related proteins associated with Alzheimer's disease are disclosed. Also provided herein is a DNA sequence encoding a novel protease inhibitor. These sequences are used in producing or constructing recombinant .beta.-amyloid core protein, .beta.-amyloid-related ...