1
Ernst Glen, Phillips Eifion, Schmiesing Richard: Biaryl diazabicycloalkane amides as nicotinic acetylcholine agonists. Astrazeneca, Ernst Glen, Phillips Eifion, Schmiesing Richard, ASTRAZENECA, February 26, 2004: WO/2004/016617 (40 worldwide citation)

Nicotinic acetylcholine receptor of formula (I) wherein D, Ar1, E and Ar2 are as defined in the specification, enantiomers, pharmaceutically acceptable salts, methods of making, pharmaceutical compositions containing and methods for using the same in the treatment or prophylaxis of psychotic disorde ...


2
Ernst Glen, Phillips Eifion, Schmiesing Richard: Aryl-substituted diazabicycloalkanes as nicotinic acetylcholine agonists.. Astrazeneca, Ernst Glen, Phillips Eifion, Schmiesing Richard, ASTRAZENECA, February 26, 2004: WO/2004/016616 (37 worldwide citation)

Nicotinic acetylcholine receptor agonists of formula I wherein a, b, c, D and R are as defined in the specification, enantiomers, pharmaceutically- acceptable salts, methods of making, pharmaceutical compositions containing and methods for using the same in the treatment or prophylaxis of psychotic ...


3
Ernst Glen, Phillips Eifion, Schmiesing Richard J: Non-amide nonanes. Astrazeneca, Astrazeneca, Ernst Glen, Phillips Eifion, Schmiesing Richard J, GLOBAL INTELLECTUAL PROPERTY, April 7, 2005: WO/2005/030777 (1 worldwide citation)

Compounds of formula (I) and pharmaceutically-acceptable salts thereof, wherein Q, E and D are as defined in the specification, enantiomers, in vivo-hydrolysable precursors and pharmaceutically-acceptable salts of the nonane derivatives, pharmaceutical compositions and formulations containing them, ...


4
Jacobs Robert, Schmiesing Richard J: Nicotinic acetycholine receptor ligands. Astrazeneca, Jacobs Robert, Schmiesing Richard J, ASTRAZENECA, June 22, 2006: WO/2006/065217 (1 worldwide citation)

Acetylcholine receptor ligands of formula I (I) wherein D, E and G are as described in the specification, diastereoisomers, enantiomers, pharmaceutically-acceptable salts, methods of making, pharmaceutical compositions containing, and methods for using the same.


5
Murray Robert John, Schmiesing Richard Jon: Diphenyl-2-piperidinone and -2-pyrrolidinone derivatives having anti-convulsant and neuroprotective activity. Fisons Corporation, Fisons, Murray Robert John, Schmiesing Richard Jon, HAYLES James Richard, August 31, 1995: WO/1995/023135

Compounds of formula (I), wherein two of R?1¿, R?2¿, R?3¿ and R?4¿ independently represent phenyl optionally substituted by one or more groups selected from halogen, hydroxy, nitro, amino, C¿1-6?alkyl and C¿1-6?alkoxy; and the ramainder of R?1¿, R?2¿, R?3¿ and R?4¿ independently represent hydrogen o ...


6
Griffith Ronald Conrad, Schmiesing Richard John, Murray Robert John: 2-phenyl-and 2-thienyl-(2)-piperidine derivatives having neuroprotective properties. Fisons Corporation, Griffith Ronald Conrad, Schmiesing Richard John, Murray Robert John, GOLDBERG Jules E, April 30, 1992: WO/1992/006957

Compounds of formula (I) in which R¿1? and R¿2?, which may be the same or different, represent hydrogen or C¿1-6? alkyl, R¿3? and R¿4? independently represent one or more radicals selected from hydrogen, NH¿2?, NO¿2?, halogen, hydroxyl, C¿1-6? alkoxy or C¿1-6? alkyl, X represents S or a -CH=CH- grou ...


7
Griffith Ronald Conrad, Murray Robert John, Schmiesing Richard John: 2-heterocyclicethylamine derivatives and their use as pharmaceuticals. Fisons Corporation, Griffith Ronald Conrad, Murray Robert John, Schmiesing Richard John, Fisons, WRIGHT Robert Gordon McRae, May 13, 1993: WO/1993/009095

Compounds of formula (I), wherein A represents C=C, S or O; Q represents a 5- or 6-membered unsaturated heterocycling ring having a nitrogen atom in the position adjacent to the point of attachment, 0-3 further heteroatoms selected from N, O and S, and substituents R?6¿ and R?7¿; R?1¿ represents H o ...


8
Griffith Ronald Conrad, Schmiesing Richard Jon, Murray Robert John: (2-thienyl) alkylamine derivatives having neuroprotective properties. Fisons Corporation, Griffith Ronald Conrad, Schmiesing Richard Jon, Murray Robert John, GOLDBERG Jules E, April 2, 1992: WO/1992/005169

Compounds of formula (I), in which: R¿1? represents hydrogen or C¿1-6? alkyl, R¿2? represents hydrogen, C¿1-6? alkyl, C¿3-6? alkenyl, C¿3-6? alkynyl or C¿3-6? cycloalkyl, R¿3? represents one or more radicals selected from hydrogen, hydroxy, C¿1-6? alkyl, C¿1-6? alkoxy, halogen, trifluoromethyl, amin ...


9
Schmiesing Richard: Quinuclidine acrylamides. Astrazeneca, Schmiesing Richard, GLOBAL INTELLECTUAL PROPERTY PATENTS, April 26, 2001: WO/2001/029034

A compound of formula (I) wherein A represents (II), (III), (IV), (V) or (VI); R represents hydrogen or methyl; R?1¿ and R?2¿ are independently hydrogen, or C¿1?-C¿4? alkyl; R?3¿ and R?4¿ are independently hydrogen, C¿1?-C¿4? alkyl or SAr, provided that at least one of R?3¿ and R?4¿ represents SAr; ...


10
Balestra Michael, Mullen George, Phillips Eifion, Schmiesing Richard: New use and novel n-azabicyclo-amide derivatives. Astrazeneca, Balestra Michael, Mullen George, Phillips Eifion, Schmiesing Richard, ASTRAZENECA, May 25, 2001: WO/2001/036417

This invention relates to new use of a compound of general formula (I) wherein: A represents (II), (III), (IV), (V), (VI); D represents oxygen, or sulfur; R?1¿ represents hydrogen or methyl; R?2¿ represents hydrogen, or C¿1?-C¿4? alkyl; and R?3¿ represents (A), (B), (C), or an enantiomer thereof, an ...