1
Heinz Gries, Douwe Rosenberg, Hanns Joachim Weinmann: Diagnostic media. Schering Aktiengesellschaft, Millen & White, March 3, 1987: US04647447 (366 worldwide citation)

A diagnostic medium contains at least one physiologically well tolerated complex salt comprising an anion of a complexing acid and one or more central ion or ions of an element with an atomic number of 21 to 29, 42, 44 or 57 to 83 and, optionally, one or more physiologically biocompatible cation or ...


2
Juergen Hilmann, Rolf Ruediger Hoffmann, Wolfgang Muetzel, Ingfried Zimmermann: Carrier liquid solutions for the production of gas microbubbles, preparation thereof, and use thereof as contrast medium for ultrasonic diagnostics. Schering Aktiengesellschaft, Millen & White, August 21, 1984: US04466442 (260 worldwide citation)

The useful lifetime and the amount of microbubbles of a size less than 50 .mu.m produced by mechanical agitation of an aqueous liquid employed as an ultrasonic contrast medium are increased by employing a liquid containing dissolved therein a tenside which reduces the surface tension of the liquid a ...


3
Michael Reinhardt, Thomas Fritzsch, Dieter Heldmann, Joachim Siegert: Ultrasonic contrast agents for color Doppler imaging. Schering Aktiengesellschaft, Millen White Zelano & Branigan, June 20, 1995: US05425366 (227 worldwide citation)

The invention relates to a method for obtaining an ultrasonic image of a patient with ultrasonic color Doppler modality with microparticulate ultrasonic contrast agents in regions where the ultrasonic contrast agents are essentially motionless.


4
Julia S Rasor, Ernest G Tickner: Microbubble precursors and apparatus for their production and use. Schering Aktiengesellschaft, Millen & White, April 14, 1987: US04657756 (219 worldwide citation)

Microbubbles are formed in a liquid, e.g., blood in order to alter the transmission characteristics thereof to electromagnetic and sonic waves transmitted therethrough, by dissolving therein a solid particulate material, preferably as a suspension in a carrier liquid in which the particulate materia ...


5
Julia S Rasor, Ernest G Tickner: Method of production and use of microbubble precursors. Schering Aktiengesellschaft, Millen & White, July 21, 1987: US04681119 (189 worldwide citation)

In the inventive method, microbubbles are formed in body liquid or carrier liquid, for example within the genitourinary or digestive systems in order to alter the transmission characteristics thereof to electromagnetic and sonic waves transmitted therethrough, by dissolving therein a solid particula ...


6
Volkmar Uhlendorf, Thomas Fritzsch, Joachim Siegert: Ultrasonic processes and circuits for performing them. Schering Aktiengesellschaft, Millen White Zelano & Branigan, April 25, 1995: US05410516 (172 worldwide citation)

A process for selective graphic representation and/or evaluation of the Doppler spectrum of objects limitedly resistant to sonic intensity, for example biological organs and tissues, by an ultrasonic process wherein a material is introduced in the examination area to be acoustically irradiated, nonl ...


7
Peter Fuchs, Jurgen Hilmann: Medicament carriers in the form of film having active substance incorporated therein. Schering Aktiengesellschaft, Millen & White, January 23, 1979: US04136145 (155 worldwide citation)

Pharmaceutical composition unit dosage forms adapted for enteral or topical administration are described, comprising a safe and effective amount of a pharmaceutically active medicament compound dissolved or uniformly dispersed in a flexible, water-soluble film carrier therefor. Admixtures of medicam ...


8
Ned S Rasor, Jurgen Hilmann, Lothar Lange, Thomas Fritzsch, Joachim Siegert, Ingfried Zimmermann: Ultrasonic contrast medium comprising gas bubbles and solid lipophilic surfactant-containing microparticles and use thereof. Schering Aktiengesellschaft, Millen White & Zelano, August 25, 1992: US05141738 (154 worldwide citation)

Microparticles which are less than 12 .mu.m in size and are formed of or comprise a solid lipophilic group-containing compound having an HLB value less than about 20 produce a long lived ultrasonically echogenic entity in aqueous liquid and are useful as left heart ultrasonic contrast image enhancin ...


9
Heinz Gries, Douwe Rosenberg, Hanns Joachim Weinmann, Ulrich Speck, Wolfgang Mutzel, Georg Alexander Hoyer, Heinrich Pfeiffer deceased: Method of enhancing NMR imaging using chelated paramagnetic ions bound to biomolecules. Schering Aktiengesellschaft, Millen White & Zelano, June 4, 1991: US05021236 (153 worldwide citation)

Agents useful for influencing the relaxation times in NMR diagnostics, contain at least one paramagnetic, physiologically compatible complex salt comprising a chelate from an open-chain or cyclic complex-forming compound containing organic nitrogen, phosphorus, oxygen and/or sulfur, and a complexed ...


10
Reinhard Schlief, Hans Poland: Ultrasonic manometry process in a fluid by means of microbubbles. Schering Aktiengesellschaft, Millen White Zelano and Branigan, March 23, 1993: US05195520 (142 worldwide citation)

The invention relates to an ultrasonic manometry process in a fluid containing stabilized micro bubbles in an ensemble, wherein ultrasonic impulses are radiated into the fluid and brought to interact with the micro bubbles. The amplitude and/or frequency alterations in the ultrasonic scatter signals ...