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Michael M Harpold, Paul Brust: Assay methods and compositions for detecting and evaluating the intracellular transduction of an extracellular signal. Salk Institute Biotechnology Industrial Associates, Brown Martin Haller & McClain, July 25, 1995: US05436128 (171 worldwide citation)

Transcription based assays that identify extracellular signals that modulate the activity of cell surface proteins are provided. Extracellular signals are identified by measuring the amount of transcription of a reporter gene in a recombinant cell that expresses the cell surface protein and contains ...


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Michael M Harpold, Paul Brust: Assay methods and compositions useful for measuring the transduction of an intracellular signal. The Salk Institute Biotechnology Industrial Associates, Brown Martin Haller & McClain, March 28, 1995: US05401629 (102 worldwide citation)

Recombinant cells are provided which are useful for assaying compounds for their agonist or antagonist activity with respect to ion channels and/or cell surface-localized receptors. In addition, assay methods employing the invention recombinant cells are provided.


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Renato Dulbecco: Viruses with recombinant surface proteins. Salk Institute Biotechnology Industrial Associates, Fitch Even Tabin & Flannery, June 3, 1986: US04593002 (89 worldwide citation)

Foreign protein segments having specific medically or commercially useful biological functions are incorporated in surface proteins of viruses. The viruses with the incorporated protein segments are convenient agents for introducing the protein segments into animals, such as humans, and are thus use ...


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Gregory C Holtz, Russell A Brierley: Method for the purification of intact, correctly-folded insulin-like growth factor-1. The Salk Institute Biotechnology Industrial Associates, Fitch Even Tabin & Flannery, July 27, 1993: US05231178 (85 worldwide citation)

Method for the recovery and purification of intact, correctly-folded, monomeric insulin-like growth factor-1 peptide from large volumes of IGF-1-containing medium are described, comprising a series of adsorption-desorption steps employing a combination of cation exchange and hydrophobic interaction ...


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Deborah Y Kwoh, Thomas R Gingeras: Prenatal sex determination of bovine cells using male-specific oligonucleotides. Salk Institute Biotechnology Industrial Associates, Fitch Even Tabin & Flannery, October 8, 1991: US05055393 (69 worldwide citation)

Compositions and methods are provided for determining the sex of Bovine embryos and fetuses employing male-specific oligonucleotides in nucleic acid probe hybridization assay methods to assay the genomic DNA of embryonic or fetal cells for the presence of male-specific sequences.


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Lorrie Daggett, Steven B Ellis, Chen Liaw, Aaron Pontsler: Nucleic acids encoding human metabotropic glutamate receptors. Salk Institute Biotechnology Industrial Associates, Stephen E Reiter, Pretty Schroeder Brueggemann & Clark, May 28, 1996: US05521297 (17 worldwide citation)

In accordance with the present invention, there are provided nucleic acids encoding human metabotropic glutamate receptor subtypes and the proteins encoded thereby. In a particular embodiment, the invention nucleic acids encode mGluR1, mGluR2, mGluR3 and mGluR5 subtypes of human metabotropic glutama ...


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Michael M Harpold, Steven B Ellis: DNA and mRNA encoding human neuronal nicotinic acetylcholine receptor compositions and cells transformed with same. The Salk Institute Biotechnology Industrial Associates, Pretty Schroeder Brueggemann & Clark, November 29, 1994: US05369028 (15 worldwide citation)

Human neuronal nicotinic acetylcholine receptor subunits are described, as are methods for producing cells containing functional receptors employing such subunits. Also described are assay methods for determining the presence of functional HnAChRs in transfected cells, and for determining the agonis ...


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