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Kevin Rodzinak
Armstrong Donna J, Hu Essa H, Kelly Michael J Iii, Layton Mark E, Li Yiwei, Liang Jun, Rodzinak Kevin J, Rossi Michael A, Sanderson Philip E, Wang Jiabing: Inhibitors of akt activity. Merck & Co, Armstrong Donna J, Hu Essa H, Kelly Michael J Iii, Layton Mark E, Li Yiwei, Liang Jun, Rodzinak Kevin J, Rossi Michael A, Sanderson Philip E, Wang Jiabing, MERCK 126 East Lincoln Avenue Rahway NJ 07065 0907, December 21, 2006: WO/2006/135627 (19 worldwide citation)

The instant invention provides for substituted naphthyridine compounds that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting Akt ...


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Furuyama Hidetomo, Goto Yasuhiro, Kawanishi Nobuhiko, Layton Mark E, Mita Takashi, Ogino Yoshio, Onozaki Yu, Rossi Michael A, Sakamoto Toshihiro, Sanderson Philip E, Wang Jiabing: Inhibitors of akt activity. Merck & Co, Banyu Pharmaceutical, Furuyama Hidetomo, Goto Yasuhiro, Kawanishi Nobuhiko, Layton Mark E, Mita Takashi, Ogino Yoshio, Onozaki Yu, Rossi Michael A, Sakamoto Toshihiro, Sanderson Philip E, Wang Jiabing, Merck & Co, December 10, 2009: WO/2009/148887 (8 worldwide citation)

The instant invention provides for substituted [1,2,4]triazolo[4,3-a]-1,5-naphthyridine compounds that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms, preferably Akt1. The invention also provides for compositions comprising such inhibi ...


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Rossi Michael A, Cormier Joel M, Smith Donald S, Gerwolls Matthew M: Thermoformed component with integral attachment structure and method. Safetynet Energy Management, Rossi Michael A, Cormier Joel M, Smith Donald S, Gerwolls Matthew M, DOLCE Marcus P, September 17, 2009: WO/2009/114577 (2 worldwide citation)

A thermoforming process capable of coining and flowing material is provided, such as for making a thermoformed energy absorber for self-attachment to a vehicle bumper beam. The energy absorber includes a thermoplastic sheet with first thickness shaped by a thermoforming process to include a base and ...


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FIJI Hannah D, KELLY Michael J III, KERN Jeffrey C, LAYTON Mark E, PERO Joseph E, REIF Alexander J, ROSSI Michael A: DÉRIVÉS DIMIDAZOPYRIDIN-2-ONE, IMIDAZOPYRIDIN-2-ONE DERIVATIVES. MERCK SHARP & DOHME, FIJI Hannah D, KELLY Michael J III, KERN Jeffrey C, LAYTON Mark E, PERO Joseph E, REIF Alexander J, ROSSI Michael A, December 20, 2012: WO/2012/174199 (1 worldwide citation)

The present invention is directed to imidazopyridin-2-one derivatives which are potentiators of metabotropic glutamate receptors, particularly the mGluR2 receptor, and which are useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and ...


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Kim Yuntae, Meissner Robert S, Mitchell Helen J, Perkins James J, Rossi Michael A, Wang Jiabing: 2-hydroxy-2-phenyl/thiophenyl propionamides as androgen receptor modulators. Merck & Co, Kim Yuntae, Meissner Robert S, Mitchell Helen J, Perkins James J, Rossi Michael A, Wang Jiabing, MERCK 126 East Lincoln Avenue Rahway NJ 07065 0907, April 24, 2008: WO/2008/048540

Compounds of structural formula (I) are modulators of the androgen receptor (AR) in a tissue selective manner. These compounds are useful in the enhancement of weakened muscle tone and the treatment of conditions caused by androgen deficiency or which can be ameliorated by androgen administration, i ...