1
Singh Rajinder, Argade Ankush, Payan Donald G, Clough Jeffrey, Keim Holger, Sylvain Catherine, Li Hui, Bhamidipati Somasekhar: Methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds. Rigel Pharmaceuticals, Singh Rajinder, Argade Ankush, Payan Donald G, Clough Jeffrey, Keim Holger, Sylvain Catherine, Li Hui, Bhamidipati Somasekhar, ROTHENBERGER Scott D, February 19, 2004: WO/2004/014382 (141 worldwide citation)

The present invention provides methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds, as well as methods of treating, preventing or ameliorating symptoms associated with such diseases. Specific examples of autoimmune diseases that can be treated or prevented with ...


2
Rajinder Singh, Ankush Argade, Donald Payan, Susan Molineaux, Sacha J Holland, Jeffrey Clough, Holger Keim, Somasekhar Bhamidipati, Catherine Sylvain, Hui Li, Alexander B Rossi: Intermediates useful for making 2,4-pyrimidinediamine compounds. Rigel Pharmaceuticals, Dechert, June 13, 2006: US07060827 (128 worldwide citation)

The present invention provides 2,4-pyrimidinediamine compounds that inhibit the IgE and/or IgG receptor signaling cascades that lead to the release of chemical mediators, intermediates and methods of synthesizing the compounds and methods of using the compounds in a variety of contexts, including in ...


3
Rajinder Singh, Ankush Argade, Hui Li, Somasekhar Bhamidipati, David Carroll, Catherine Sylvain, Jeffrey Clough, Holger Keim: Methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds. Rigel Pharmaceuticals, Dechert, October 17, 2006: US07122542 (125 worldwide citation)

The present invention provides methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds, as well as methods of treating, preventing or ameliorating symptoms associated with such diseases. Specific examples of autoimmune diseases that can be treated or prevented with ...


4
Li Hui, Thota Sambaiah, Carroll David, Argade Ankush, Tso Kin, Sran Arvinder, Clough Jeffrey, Keim Holger, Bhamidipati Somasekhar, Taylor Vanessa, Cooper Robin, Singh Rajinder, Wong Brian: Compositions and methods for inhibition of the jak pathway. Rigel Pharmaceuticals, Li Hui, Thota Sambaiah, Carroll David, Argade Ankush, Tso Kin, Sran Arvinder, Clough Jeffrey, Keim Holger, Bhamidipati Somasekhar, Taylor Vanessa, Cooper Robin, Singh Rajinder, Wong Brian, FLICK Karen E, December 14, 2006: WO/2006/133426 (118 worldwide citation)

The invention encompasses compounds having formula (I-V) and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, may be therapeutically useful.


5
Rajinder Singh, Ankush Argade, Li Hui, Bhamidipati Somasekhar, Carroll David, Sylvain Catherine, Clough Jeffrey, Keim Holger: 2,4-pyrimidinediamine compounds for use in the treatment or prevention of autoimmune diseases. Rigel Pharmaceuticals, Rajinder Singh, Ankush Argade, Li Hui, Bhamidipati Somasekhar, Carroll David, Sylvain Catherine, Clough Jeffrey, Keim Holger, ROTHENBERGER Scott D, February 24, 2005: WO/2005/016893 (115 worldwide citation)

The present invention provides methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds, as well as methods of treating, preventing or ameliorating symptoms associated with such diseases. Specific examples of autoimmune diseases that can be treated or prevented with ...


6
Argade Ankush, Singh Rajinder, Li Hui, Carroll David, Catalano Susan: 2,4-pyrimidinediamine compounds and uses as anti-proliferative agents. Rigel Pharmaceuticals, Argade Ankush, Singh Rajinder, Li Hui, Carroll David, Catalano Susan, PEASE Ann M Caviani, February 17, 2005: WO/2005/013996 (102 worldwide citation)

The present invention provides 2,4-pyrimidinediamine compounds having antiproliferative activity, compositions comprising the compounds and methods of using the compounds to inhibit cellular proliferation and to treat proliferative diseases such as tumorigenic cancers.


7
Singh Rajinder, Bhamidipati Somasekhar, Masuda Esteban: Prodrugs of 2,4-pyrimidinediamine compounds and their uses. Rigel Pharmaceuticals, Singh Rajinder, Bhamidipati Somasekhar, Masuda Esteban, FLICK Karen E, July 27, 2006: WO/2006/078846 (88 worldwide citation)

The present disclosure provides prodrugs of biologically active 2,4-pyrimidinediamine compounds, compositions comprising the prodrugs, intermediates and methods for synthesizing the prodrugs and methods of using the prodrugs in a variety of applications.


8
Rajinder Singh, Ankush Argade, Donald Payan, Susan Molineaux, Sacha J Holland, Jeffrey Clough, Holger Keim, Somasekhar Bhamidipati, Catherine Sylvain, Hui Li, Alexander B Rossi: 2,4-pyrimidinediamine compounds and their uses. Rigel Pharmaceuticals, Foley & Lardner, James J Diehl, Brian D Griedel, February 19, 2008: US07332484 (79 worldwide citation)

The present invention provides 2,4-pyrimidinediamine compounds that inhibit the IgE and/or IgG receptor signaling cascades that lead to the release of chemical mediators, intermediates and methods of synthesizing the compounds and methods of using the compounds in a variety of contexts, including in ...


9
Rajinder Singh, Ankush Argade, Donald Payan, Susan Molineaux, Sacha J Holland, Jeffrey Clough, Holger Keim, Somasekhar Bhamidipati, Catherine Sylvain, Hui Li, Alexander B Rossi: 2,4-pyrimidinediamine compounds and their uses. Rigel Pharmaceuticals, Foley & Lardner, James J Diehl, July 7, 2009: US07557210 (76 worldwide citation)

The present invention provides 2,4-pyrimidinediamine compounds that inhibit the IgE and/or IgG receptor signaling cascades that lead to the release of chemical mediators, intermediates and methods of synthesizing the compounds and methods of using the compounds in a variety of contexts, including in ...


10
Rajinder Singh, Ankush Argade, Donald Payan, Susan Molineaux, Sacha J Holland, Jeffrey Clough, Holger Keim, Somasekhar Bhamidipati, Catherine Sylvain, Hui Li, Alexander B Rossi: 2,4-pyrimidinediamine compounds and their uses. Rigel Pharmaceuticals, Foley & Lardner, James J Diehl, Brian D Griedel, February 12, 2008: US07329671 (76 worldwide citation)

The present invention provides 2,4-pyrimidinediamine compounds that inhibit the IgE and/or IgG receptor signaling cascades that lead to the release of chemical mediators, intermediates and methods of synthesizing the compounds and methods of using the compounds in a variety of contexts, including in ...