1
Michel Colin, Daniel Guenard, Francoise Gueritte Voegelein, Pierre Potier: Taxol derivatives, their preparation and pharmaceutical compositions containing them. Rhone Poulenc Sante, Stevens Davis Miller & Mosher, March 21, 1989: US04814470 (250 worldwide citation)

Taxol derivatives of formula ##STR1## in which R represents hydrogen or acetyl, one of R.sub.1 or R.sub.2 represents hydroxy and the other represents tert-butoxycarbonylamino and their isomers are useful antitumor agents.


2
Carpentier Alain F: Cardiac valvular support prosthesis. Rhone Poulenc, April 18, 1972: US3656185 (247 worldwide citation)

A cardiac valvular prosthesis, e.g., for the mitral valve, consisting solely of an annular or part-annular member adapted to fit against the base of the cusps of a human heart valve, and suture means for securing the member in place. The prosthesis cooperates with the natural valve cusps of the pati ...


3
Alain Carpentier, Xavier Leclercq, Jean Paris: Support for a natural human heart valve. Rhone Poulenc, Stevens Davis Miller & Mosher, November 1, 1977: US04055861 (243 worldwide citation)

A support for a natural human heart valve is disclosed, said support consisting of an annular or part annular semi-rigid frame having the shape of at least a substantial portion of the periphery of said natural heart valve at the base of its cusps, the frame being completely or partly enclosed in a ...


4
Jacques Foucras: Electrically heated flexible tube having temperature measuring probe. Rhone Poulenc, Stevens Davis Miller & Mosher, July 26, 1977: US04038519 (220 worldwide citation)

A flexible heating tube especially for medical use, e.g. for taking blood away from and returning it to the body, in which a flexible pipe of transparent plastics material is provided with at least one electrical helical resistance heating conductor and at least one helical filiform temperature meas ...


5
David M Stalker: Haloarylnitrile degrading gene, its use, and cells containing the gene. Rhone Poulenc Agrochimie, Morgan & Finnegan, March 7, 1989: US04810648 (168 worldwide citation)

Nitrilase enzymes specific for the hyrdolsis of the nitrile group of bromoxynil, nucleotide sequences encoding for such enzymes, and transformed cells in which the nitrilase expression if foreign are provided. The transformed cells are capable of expressing the nitrilase enzyme to provide detoxifica ...


6
Alfred P Spada, Michael R Myers, Martin P Maguire, Paul E Persons: Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase. Rhone Poulenc Rorer Pharmaceuticals, James A Nicholson, Martin F Savitzky, Raymond S Parker III, January 2, 1996: US05480883 (166 worldwide citation)

This invention relates to bis mono- and/or bicyclic aryl and/or heteroaryl compounds exhibiting protein tyrosine kinase inhibition activity. More specifically, it relates to the method of inhibiting abnormal cell proliferation in a patient suffering from a disorder characterized by such proliferatio ...


7
Michel Colin, Daniel Guenard, Francoise Gueritte Voegelein, Pierre Potier: Process for the preparation of taxol and 10-deacetyltaxol. Rhone Poulenc Sante, Stevens Davis Miller & Mosher, August 15, 1989: US04857653 (157 worldwide citation)

Taxol and 10-deacetyltaxol are prepared from a compound of formula: ##STR1## in which R' represents acetyl or 2,2,2-trichloroethoxycarbonyl radical, by removal of the t-butoxycarbonyl radical, benzoylation of the amine product obtained, and removal of the 2,2,2-trichloroethoxycarbonyl group(s).


8
Emmanuel Dos Santos, Pascal Mettvier, Michel Gubelmann: Process for treating a material comprising a polymer by hydrolysis. Rhone Poulenc Chimie, Burns Doane Swecker & Mathis L, May 18, 1999: US05905168 (145 worldwide citation)

Process for the treatment of a material comprising a polymer, especially a polyamide. The process consists in subjecting the polyamide to hydrolysis in the presence of a hydrolyzing nitrous grouping and transforming the hydrolyzed compounds into diacids. The treatment of a polyamide 6.6 results in t ...


9
Michael R Myers, Alfred P Spada, Martin P Maguire, Paul E Persons: Aryl and heteroaryl quinazoline compounds which inhibit EGF and/or PDGF receptor tyrosine kinase. Rhone Poulenc Rorer Pharmaceuticals, Raymond S Parker III, James A Nicholson, Martin F Savitzky, January 20, 1998: US05710158 (144 worldwide citation)

This invention relates to the modulation and/or inhibition of cell signaling, cell proliferation, cell inflammatory response, the control of abnormal cell growth and cell reproduction. More specifically, this invention relates to the use of mono- and/or bicyclic aryl or heteroaryl quinazoline compou ...


10
Alfred P Spada, Martin P Maquire, Paul E Persons, Michael R Myers: Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase. Rhone Poulenc Rorer Pharmaceuticals, James A Nicholsen, Martin F Savitzky, Raymond S Parker III, April 25, 1995: US05409930 (127 worldwide citation)

This invention relates to bis mono- and/or bicyclic aryl and/or heteroaryl compounds exhibiting protein tyrosine kinase inhibition activity. More specifically, it relates to the method of inhibiting abnormal cell proliferation in a patient suffering from a disorder characterized by such proliferatio ...