1
Jeffrey A Hubbell: Injectable hydrogel compositions. Reprogenesis, Baker & Botts, October 10, 2000: US06129761 (537 worldwide citation)

Slowly polymerizing hydrogels are provided which are useful as a means of delivering large numbers of isolated cells via injection. The gels promote engraftment and provide three dimensional templates for new cell growth. The resulting tissue is similar in composition and histology to naturally occu ...


2
Hubbell Jeffrey A: Injectable hydrogel compositions. Reprogenesis, April 15, 1998: EP0835143-A1 (7 worldwide citation)

Slowly polymerizing hydrogels are provided which are useful as a means of delivering large numbers of isolated cells via injection. The gels promote engraftment and provide three-dimensional templates for new cell growth. The resulting tissue is similar in composition and histology to naturally occu ...


3
Borland Kermit M, Zhou Tao, Nelson Gordon P, Atala Anthony, Omstead Daniel R: Improved hydrogel for tissue engineering. Reprogenesis, Borland Kermit M, Zhou Tao, Nelson Gordon P, Atala Anthony, Omstead Daniel R, sPOSORSKE Laurence H, June 18, 1998: WO/1998/025653 (1 worldwide citation)

This invention provides compositions for use in implanting into an animal comprising a biodegradable, biocompatible polymer which forms a hydrogel upon cross-linking. In a preferred mode, the polymer is cross-linked by multivalent ions; more preferably, a soluble salt of a multivalent ion and a spar ...


4
Borland Kermit M, Omstead Daniel R, Zhou Tao, Nelson Gordon P: Improved hydrogel for tissue engineering. Reprogenesis, July 5, 2000: EP1015042-A1

This invention provides compositions for use in implanting into an animal comprising a biodegradable, biocompatible polymer which forms a hydrogel upon cross-linking. In a preferred mode, the polymer is cross-linked by multivalent ions; more preferably, a soluble salt of a multivalent ion and a spar ...


5
Gentile Frank T, Melo Antonio P, Birkhead James R, Weitzner Barry D, Lotito Mark A: Sterile packaging of live material with improved storage characteristics. Reprogenesis, Gentile Frank T, Melo Antonio P, Birkhead James R, Weitzner Barry D, Lotito Mark A, POSORSKE Laurence H, February 8, 2001: WO/2001/008630

A storage package is disclosed. The storage package comprises an outer container; a second outer container completely enclosing the outer container; an access portal transiting the outer container; a cell containing compartment; a stabilizing bath compartment, wherein the stabilizing bath compartmen ...


6
Hubbell Jeffrey A: Injectable hydrogel compositions. Reprogenesis, PABST Patrea L, December 19, 1996: WO/1996/040304

Slowly polymerizing hydrogels are provided which are useful as a means of delivering large numbers of isolated cells via injection. The gels promote engraftment and provide three-dimensional templates for new cell growth. The resulting tissue is similar in composition and histology to naturally occu ...


7
Stovall Shawn E: Repair of intervertebral disks. Reprogenesis, Stovall Shawn E, POSORSKE Laurence H, February 4, 1999: WO/1999/004720

This invention is a method of using a cell containing hydrogel suspension for treating a herniated intervertebral disk (10) by implanting a cell suspension into a patient, thereby forming a cell containing hydrogel adherent to at least one surface of the annulus fibrosus (20) of the herniated disk ( ...


8
Borland Kermit M, Zhou Tao, Nelson Gordon P, Atala Anthony: Improved hydrogel composition. Reprogenesis, Children S Medical Center Corporation, POSORSKE Laurence H, June 18, 1998: WO/1998/025575

This invention provides compositions for use in implanting cells into an animal comprising cells (which may be dissociated cells and/or cell aggregates); a biodegradable, biocompatible polymer which forms a hydrogel upon cross-linking by multivalent ions; a soluble salt of a multivalent ion; and a s ...


9
Borland Kermit M, Marler Jennifer: Soft tissue reconstructor and method of use. Reprogenesis, Beth Israel Deaconess Medical Center, Borland Kermit M, Marler Jennifer, TATE Rodger L, October 14, 1999: WO/1999/051164

This invention is directed to methods of tissue reconstruction and kits and apparatus for the practice of the method. In the method, an injection means, which may be a hollow tube, is positioned intradermally, subdermally, or subcutaneously beneath a soft tissue defect. A tissue shaping means is pos ...


10
Omstead Daniel, Weitzner Barry, Melo Antonio, White Desmond: Method and apparatus for aseptically packaging and dispensing live material. Reprogenesis, sPOSORSKE Laurence H, July 29, 1999: WO/1999/037233

A method and apparatus for aseptically packaging and dispensing live material are disclosed. The apparatus provides a duplex package comprising an inner container and an outer container completely enclosing the inner container. An access portal transits the outer container and is operative to asepti ...