1
Michael R Imrich, John K Zeis, Steven P Miller, Allan D Pronovost: Lateral flow medical diagnostic assay device with sample extraction means. Quidel Corporation, Townsend and Townsend Khourie and Crew, May 16, 1995: US05415994 (136 worldwide citation)

The present invention provides devices, methods, and kits for treatment and detection of analytes requiring pretreatment in samples. One-step treatment and detection is possible utilizing the devices and methods of the present invention.


2
Siu Yin Wong, Fon Chiu Mia Chen, Eugene Fan: Immunodiagnostic device. Quidel Corporation, Knobbe Martens Olson & Bear, June 9, 1998: US05763262 (111 worldwide citation)

A device for assaying biological fluids for molecules contained therein comprising a container, material situated in the container for absorbing fluid and in communication with an antibody or antigen impregnated matrix, wherein the matrix is accessible to the exterior of the container through a funn ...


3
Catherine Pawlak, Allan D Pronovost, Keren Goins: One-step lateral flow nonbibulous assay. Quidel Corporation, Morrison & Foerster, June 23, 1998: US05770460 (76 worldwide citation)

A particularly efficient design for a nonbibulous lateral flow one step assay for an analyte in a biological sample is disclosed. In the improved device of the invention, three zones which are in nonbibulous lateral flow contact are employed: a sample receiving zone, a labeling zone, and a capture z ...


4
Catherine Pawlak, Allan D Pronovost, Keren Goins: One-step lateral flow nonbibulous assay. Quidel Corporation, Morrison & Foerster, June 16, 1998: US05766961 (62 worldwide citation)

A particularly efficient design for a nonbibulous lateral flow one step assay for an analyte in a biological sample is disclosed. In the improved device of the invention, three zones which are in nonbibulous lateral flow contact are employed: a sample receiving zone, a labeling zone, and a capture z ...


5
Jeremy Jerome, Mark Daquipa, Bruce Jacono, Hans Boehringer: Method for adding an apparent non-signal line to a lateral flow assay. Quidel Corporation, Morrison & Foerster, February 15, 2005: US06855561 (61 worldwide citation)

A test device and method for determining the presence or absence of an analyte in a fluid sample, the test device including a support bearing a mark thereon, and a matrix defining an axial flow path. In operation, an observation area in the test device becomes transparent, thereby allowing the user ...


6
Allan D Pronovost, Hans Boehringer, Ya Chen Hsu: One-step lateral flow assays. Quidel Corporation, Morrison & Foerster, December 2, 2003: US06656744 (55 worldwide citation)

The efficiency and accuracy of one-step lateral flow assays can be improved by employing more efficient binding between participants in labeling and capture. Thus, in addition to analyte/anti-analyte interactions, specific binding is achieved through members of an irrelevant specific binding pair. A ...


7
John Burd, Steven Miller, Gerald Rowley, Allan Pronovost: Red blood cell separation means for specific binding assays. Quidel Corporation, Morrison & Foerster, August 17, 1999: US05939331 (54 worldwide citation)

A method and device for detecting the presence, absence or amount of an analyte in a whole blood sample is disclosed. The device comprises four zones, a sample receiving zone, a labeling zone, a capture zone and an absorbent zone. The sample receiving zone contains an irreversibly immobilized reagen ...


8
Allan D Pronovost, Cathy A Bacquet, Jan W Pawlak, Theodore T Sand: Assay device for one step detection of analyte. Quidel Corporation, Morrison & Foerster, November 11, 1997: US05686315 (52 worldwide citation)

A "one step" device for the detection of analytein clinical assays is disclosed. A visible label comprising a visible moiety and a ligand that binds to or competes with analyte is contained in a fluid conducting membrane or prefilter; and the analyte and associated ligand are conducted by the flow o ...


9
Allan D Pronovost, Theodore T Lee: Assays and devices for distinguishing between normal and abnormal pregnancy. Quidel Corporation, Townsend and Townsend and Crew, July 28, 1998: US05786220 (49 worldwide citation)

Methods and devices for distinguishing between normal and abnormal pregnancies are provided. The methods rely on determining the concentration of progesterone or progesterone metabolite in a patient sample, where a concentration above a threshold value is indicative of a normal pregnancy. Preferably ...


10
Hans R Boehringer, Jan L Sabran, Ya Chen Hsu, Bentley Tam: Controlled sensitivity immunochromatographic assay. Quidel Corporation, Knobbe Martens Olson & Bear, May 28, 1996: US05521102 (46 worldwide citation)

An improved one-step immunochromatographic assay which involves the binding of a predetermined amount of analyte to an antibody, enabling the control of the assay sensitivity, is disclosed. The system is especially useful as a controlled sensitivity fecal occult blood assay. Antibodies to a desired ...