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Edge Albert, Seyb Kathleen, Glicksman Marcie, Qiao Lixin, Cuny Gregory D, Jeon Sang Jun: Compounds that enhance atoh-1 expression. Massachusetts Eye & Ear Infirmary, The Brigham And Women S Hospital, Edge Albert, Seyb Kathleen, Glicksman Marcie, Qiao Lixin, Cuny Gregory D, Jeon Sang Jun, FREEMAN John Wet al, August 13, 2009: WO/2009/100438 (13 worldwide citation)

This invention generally provides compounds, pharmaceutical compositions, and methods for their use, which include methods that result in increased expression in an Atoh1 gene (e.g., Hath1) in a biological cell. More specifically, the invention relates to the treatment of diseases and/or disorders t ...


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Carter Stephen G, Patel Kanu, Zhu Zhen, Qiao Lixin: Bifunctional synthetic molecules. Biochemics, Carter Stephen G, Patel Kanu, Zhu Zhen, Qiao Lixin, LEMACK Kevin S, December 24, 2008: WO/2008/156758 (2 worldwide citation)

The synthesis and use of bifunctional molecules to improve the topical and transdermal delivery efficiency of various types of therapeutic agents or agents designed to promote the transdermal delivery of those therapeutic agents either into the skin tissue or into the systemic circulation. Three maj ...


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Kozikowski Alan P, Wang Shaomeng, Qiao Lixin: Substituted 2-pyrrolidinone activators of pkc. Univ Georgetown, Kozikowski Alan P, Wang Shaomeng, Qiao Lixin, July 5, 2000: EP1015427-A1

Compounds of formula (I) wherein R1 and R2 are each independently (C1-C15)alkyl, (C2-C15)alkenyl, (C2-C15)alkynyl, (C3-C8)cycloalkyl, (C3-C8)cycloalkyl(C1-C10)alkyl, (C3-C8)cycloalkyl(C1-C15)alkenyl, (C3-C8)cycloalkyl(C1-C15)alkynyl, (C1-C15)alkoxy, (C1-C15)alkanoyl, (C1-C15)alkanoyloxy, aryl, heter ...


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Qiao Lixin, Etcheberrigaray Rene: Phosphinylmethyl and phosphorylmethyl succinic and glutaric acid analogs as $g(b)-secretase inhibitors. Neurologic, Qiao Lixin, Etcheberrigaray Rene, SCHULMAN Robert M, December 5, 2002: WO/2002/096897

The invention provides a compound of formula (I), or salts or hydrates thereof, useful as beta-secretase inhibitors. The invention further relates to a method of reducing plaque formation, particularly useful in the treatment of Alzheimer's disease.


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Qiao Lixin, Etcheberrigaray Rene, Kozikowski Alan, Zhao Lianyun: Rigid pyrrolidone modulators of pkc. Georgetown University, Neurologic, Qiao Lixin, Etcheberrigaray Rene, Kozikowski Alan, Zhao Lianyun, GOLLIN Michael A, November 8, 2001: WO/2001/083449

Compounds of the general formula (I): wherein substituents at R?1¿, R?2¿, R?3¿ and R?4¿ have any of the values defined in the specification, and their pharmaceutically acceptable salts, are PKC modulators and are useful for treating diseases, such as, for example, cancers including prostate cancer, ...


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Kozikowski Alan P, Wang Shaomeng, Qiao Lixin: Substituted 2-pyrrolidinone activators of pkc. Georgetown University, Kozikowski Alan P, Wang Shaomeng, Qiao Lixin, VIKSNINS Ann S, March 18, 1999: WO/1999/012901

Compounds of formula (I) wherein R¿1? and R¿2? are each independently (C¿1?-C¿15?)alkyl, (C¿2?-C¿15?)alkenyl, (C¿2?-C¿15?)alkynyl, (C¿3?-C¿8?)cycloalkyl, (C¿3?-C¿8?)cycloalkyl(C¿1?-C¿10?)alkyl, (C¿3?-C¿8?)cycloalkyl(C¿1?-C¿15?)alkenyl, (C¿3?-C¿8?)cycloalkyl(C¿1?-C¿15?)alkynyl, (C¿1?-C¿15?)alkoxy, (C ...