1
Thomas M Brennan: Method and apparatus for conducting an array of chemical reactions on a support surface. ProtoGene Laboratories, Banner & Allegretti, December 12, 1995: US05474796 (678 worldwide citation)

The invention provides apparatus and methods for making arrays of functionalized binding sites on a support surface. The invention further provides apparatus and methods for sequencing oligonucleotides and for identifying the amino acid sequence of peptides that bind to biologically active macromole ...


2
Thomas M Brennan: Apparatus for diverse chemical synthesis using two-dimensional array. Protogene Laboratories, Flehr Hohbach Test Albritton & Herbert, December 14, 1999: US06001311 (112 worldwide citation)

A chemical synthesis apparatus (20) for building chemical compounds includes a head assembly (21) having an array of nozzles (22) with each nozzle or plurality of nozzles coupled to a reservoir (23) of liquid reagent (24), and a base assembly (25) having an array of reaction wells (26). A transport ...


3
Thomas M Brennan: Method and apparatus for conducting an array of chemical reactions on a support surface. Protogene Laboratories, Albert P Halluin, Wallace Wu, Howrey Simon Arnold & White, April 3, 2001: US06210894 (65 worldwide citation)

The invention provides apparatus and methods for making arrays of functionalized binding sites on a support surface. The invention further provides apparatus and methods for sequencing oligonucleotides and for identifying the amino acid sequence of peptides that bind to biologically active macromole ...


4
Thomas M Brennan: Method and apparatus for conducting an array of chemical reactions on a support surface. Protogene Laboratories, Albert P Halluin, John A Howrey & Simon Bendrick, November 16, 1999: US05985551 (64 worldwide citation)

The invention provides apparatus and methods for making arrays of functionalized binding sites on a support surface. The invention further provides apparatus and methods for sequencing oligonucleotides and for identifying the amino acid sequence of peptides that bind to biologically active macromole ...


5
Thomas M Brennan, Albrecht W Frauendorf: Method and composition for chemical synthesis using high boiling point organic solvents to control evaporation. Protogene Laboratories, Albert P Halluin, Wallace Wu, Howrey Simon Arnold & White, January 23, 2001: US06177558 (18 worldwide citation)

A method for reducing evaporation of a liquid reagent solution during solid phase, micro-scale chemical synthesis of a molecule comprising sub-units on an open environment solid support surface. The method includes the steps of providing an open solid support surface including at least one binding s ...


6
Thomas M Brennan, Albrecht W Frauendorf: Method and composition for chemical synthesis on an open environment support surface using high boiling point organic solvents to control evaporation. Protogene Laboratories, Albert P Halluin, Wallace Wu, Howrey Simon Arnold & White, January 8, 2002: US06337393 (4 worldwide citation)

A method for reducing evaporation of a liquid reagent solution during solid phase, micro-scale chemical synthesis of a molecule comprising sub-units on an open environment solid support surface. The method includes the steps of providing an open solid support surface including at least one binding s ...


7
Brennan Thomas M, Frauendorf Albrecht W: Oligonucleotide synthesis using high boiling point solvents. Protogene Laboratories, HALLUIN Albert P, May 27, 1999: WO/1999/025724 (4 worldwide citation)

A method for reducing evaporation of a liquid reagent solution during solid phase, micro-scale chemical synthesis of a molecule comprising sub-units on an open environment solid support surface. The method includes the steps of providing an open solid support surface including at least one binding s ...


8
Brennan Thomas M, Heyneker Herbert L: Methods and compositions for economically synthesizing and assembling long dna sequences. Protogene Laboratories, Brennan Thomas M, Heyneker Herbert L, HALLUIN Albert P, September 14, 2000: WO/2000/053617 (2 worldwide citation)

the present invention relates to a cost-effective method of assembling long DNA sequences from short synthetic oligonucleotides. More specifically, short oligonucleotides are synthesized $i(in situ) on a solid support and subsequently cleaved from the solid support prior to or during the assembly in ...


9
Tm Brennan, Aw Frauendorf: Oligonucleotide synthesis using high boiling point solvents. Protogene Laboratories, chen wenjing, March 7, 2001: CN98812350

A method for reducing evaporation of a liquid reagent solution during solid phase, micro-scale chemical synthesis of a molecule comprising sub-units on an open environment solid support surface. The method includes the steps of providing an open solid support surface including at least one binding s ...


10
Brennan Thomas A: Apparatus and method for diverse chemical synthesis using multi-dimension movable arrays. Protogene Laboratories, Brennan Thomas A, BREZNER David J, August 6, 1998: WO/1998/033586

A chemical synthesis apparatus (20) for building chemical compounds including a head assembly (21) having an array of movable nozzles coupled to reservoirs of liquid reagents and a base assembly having an array of reaction wells (26) is described. A transport mechanism aligns selected nozzle columns ...