1
Thomas M Brennan: Method and apparatus for conducting an array of chemical reactions on a support surface. ProtoGene Laboratories, Banner & Allegretti, December 12, 1995: US05474796 (637 worldwide citation)

The invention provides apparatus and methods for making arrays of functionalized binding sites on a support surface. The invention further provides apparatus and methods for sequencing oligonucleotides and for identifying the amino acid sequence of peptides that bind to biologically active macromole ...


2
Thomas M Brennan: Apparatus for diverse chemical synthesis using two-dimensional array. Protogene Laboratories, Flehr Hohbach Test Albritton & Herbert, December 14, 1999: US06001311 (108 worldwide citation)

A chemical synthesis apparatus (20) for building chemical compounds includes a head assembly (21) having an array of nozzles (22) with each nozzle or plurality of nozzles coupled to a reservoir (23) of liquid reagent (24), and a base assembly (25) having an array of reaction wells (26). A transport ...


3
Thomas M Brennan: Method and apparatus for conducting an array of chemical reactions on a support surface. Protogene Laboratories, Albert P Halluin, John A Howrey & Simon Bendrick, November 16, 1999: US05985551 (63 worldwide citation)

The invention provides apparatus and methods for making arrays of functionalized binding sites on a support surface. The invention further provides apparatus and methods for sequencing oligonucleotides and for identifying the amino acid sequence of peptides that bind to biologically active macromole ...


4
Thomas M Brennan: Method and apparatus for conducting an array of chemical reactions on a support surface. Protogene Laboratories, Albert P Halluin, Wallace Wu, Howrey Simon Arnold & White, April 3, 2001: US06210894 (60 worldwide citation)

The invention provides apparatus and methods for making arrays of functionalized binding sites on a support surface. The invention further provides apparatus and methods for sequencing oligonucleotides and for identifying the amino acid sequence of peptides that bind to biologically active macromole ...


5
Thomas M Brennan, Albrecht W Frauendorf: Method and composition for chemical synthesis using high boiling point organic solvents to control evaporation. Protogene Laboratories, Albert P Halluin, Wallace Wu, Howrey Simon Arnold & White, January 23, 2001: US06177558 (13 worldwide citation)

A method for reducing evaporation of a liquid reagent solution during solid phase, micro-scale chemical synthesis of a molecule comprising sub-units on an open environment solid support surface. The method includes the steps of providing an open solid support surface including at least one binding s ...


6
Thomas M Brennan, Albrecht W Frauendorf: Method and composition for chemical synthesis on an open environment support surface using high boiling point organic solvents to control evaporation. Protogene Laboratories, Albert P Halluin, Wallace Wu, Howrey Simon Arnold & White, January 8, 2002: US06337393 (4 worldwide citation)

A method for reducing evaporation of a liquid reagent solution during solid phase, micro-scale chemical synthesis of a molecule comprising sub-units on an open environment solid support surface. The method includes the steps of providing an open solid support surface including at least one binding s ...


7
Tm Brennan, Aw Frauendorf: Oligonucleotide synthesis using high boiling point solvents. Protogene Laboratories, chen wenjing, March 7, 2001: CN98812350

A method for reducing evaporation of a liquid reagent solution during solid phase, micro-scale chemical synthesis of a molecule comprising sub-units on an open environment solid support surface. The method includes the steps of providing an open solid support surface including at least one binding s ...


8
Brennan Thomas A: Apparatus and method for diverse chemical synthesis using multi-dimension movable arrays. Protogene Laboratories, Brennan Thomas A, BREZNER David J, August 6, 1998: WO/1998/033586

A chemical synthesis apparatus (20) for building chemical compounds including a head assembly (21) having an array of movable nozzles coupled to reservoirs of liquid reagents and a base assembly having an array of reaction wells (26) is described. A transport mechanism aligns selected nozzle columns ...


9
Butler John H, Brennan Thomas M: Method and apparatus for in situ synthesis on a solid support. Protogene Laboratories, Butler John H, Brennan Thomas M, HALLUIN Albert P, February 28, 2002: WO/2002/016023

The present invention relates to methods for fabricating solid supports. More specifically, the present invention features methods for fabricating solid supports for in situ synthesis and for carrying out large numbers of reactions. The present invention also features solid supports with in situ syn ...


10
Brennan Thomas M: Method and apparatus for conducting an array of chemical reactions on a support surface. Protogene Laboratories, McDONNELL John J, December 8, 1994: WO/1994/027719

The invention provides apparatus and methods for making arrays of functionalized binding sites on a support surface. The invention further provides apparatus and methods for sequencing oligonucleotides and for identifying the amino acid sequence of peptides that bind to biologically active macromole ...



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