1
David J Roach, Tom W Yang, Roger A O Neill, Robert T Loder Jr, Peter B Vander Horn: Automated micro-volume assay system. ProteinSimple, September 20, 2011: US08021611 (19 worldwide citation)

An automated assay system is described with stations for placement of materials to be used in an assay of materials inside capillaries and an automated gripper for manipulating capillaries. The system includes a separation and immobilization station where reactions inside the capillaries take place ...


2
Jiaqi Wu, Tiemin Huang, Arthur H Watson: Method and apparatus for precise selection and extraction of a focused component in isoelectric focusing performed in micro-channels. ProteinSimple, Cooley, June 28, 2016: US09377440 (3 worldwide citation)

An apparatus and method are disclosed for the precise selection and extraction of a selected analyte in a focused zone produced by isoelectric focusing performed in micro-channels. A cross-channel microfluidic device comprises a sample mixture introduction and separation channel and an extraction ch ...


3
Roger A O Neill, Marc Glazer, Tom W Yang, Daniel J Suich, Karl O Voss: Methods and devices for analyte detection. ProteinSimple, April 5, 2016: US09304133 (1 worldwide citation)

Methods and apparatus are provided to resolve analytes within a fluid path using isoelectric focusing, gel electrophoresis, or other separation means. Materials within the fluid path that are compatible with these separation means are used to attach resolved analytes to the wall of the fluid path. A ...


4
Tom Weisan Yang, Arunashree Bhamidipati, Andrei V Bordunov, James Eugene Knittle, Roger A O Neill, Karl O Voss: Methods and devices for analyte detection. ProteinSimple, July 26, 2016: US09400277 (1 worldwide citation)

Methods for detecting one or more analytes, such as a protein, in a fluid path are provided. The methods include resolving, immobilizing and detecting one or more analytes in a fluid path, such as a capillary. Also included are devices and kits for performing such assays.


5
Frederick David King, Clark Adrien Merchant, Peter Oma: Method and particle analyzer for determining a broad particle size distribution. ProteinSimple, March 25, 2014: US08681215 (1 worldwide citation)

A method and a particle analyzer are provided for determining a particle size distribution of a liquid sample including particles of a lower size range, particles of an intermediate size range, and particles of an upper size range. A dark-field image frame is captured in which the particles of the l ...


6
Jiaqi Wu: Dual wavelength isoelectric focusing for determining drug load in antibody drug conjugates. ProteinSimple, Cooley, October 31, 2017: US09804079

Provided herein are IEF focusing methods for determining the number of drug molecules present in at least one antibody-drug conjugate (ADC) species subpopulation. In one embodiment, the method comprises performing free solution isoelectric focusing on a sample comprising at least one ADC species, to ...


7
Tiemin Huang, Jiaqi Wu: Method to perform limited two dimensional separation of proteins and other biologicals. ProteinSimple, October 23, 2018: US10107782

A method and apparatus are provided for performing capillary isoelectric focusing followed by mobilization of the focused zones by induced hydrodynamic flow or chemical mobilization. These two dimensions of separation are integrated with real-time whole-channel electrophoresis detection and automati ...


8
Tom W Yang, David John Roach: Apparatus, systems, and methods for capillary electrophoresis. ProteinSimple, Cooley, September 19, 2017: US09766206

An apparatus includes a body portion that defines a reservoir and a set of substantially flexible capillaries. The set of substantially flexible capillaries are fixedly coupled to the body portion and in fluid communication with the reservoir. A connector is configured to be coupled to the body port ...


9
David J Roach, Tom W Yang, Roger A O Neill, Robert T Loder Jr: Automated micro-volume assay system. ProteinSimple, January 27, 2015: US08940232

An automated assay system is described with stations for placement of materials to be used in an assay of materials inside capillaries and an automated gripper for manipulating capillaries. The system includes a separation and immobilization station where reactions inside the capillaries take place ...


10
Frederick David King, Clark Adrien Merchant, Peter Oma: Method and particle analyzer for determining a broad particle size distribution. ProteinSimple, June 7, 2016: US09360410

A method and a particle analyzer are provided for determining a particle size distribution of a liquid sample including particles of a lower size range, particles of an intermediate size range, and particles of an upper size range. A dark-field image frame is captured in which the particles of the l ...