1
Cary L Queen, Harold E Selick: Humanized immunoglobulins. Protein Design Labs, Townsend and Townsend and Crew, December 17, 1996: US05585089 (1552 worldwide citation)

Novel methods for producing, and compositions of humanized immunoglobulins having one or more complementarity determining regions (CDR's) and possible additional amino acids from a donor immunoglobulin and a framework region from an accepting human immunoglobulin are provided. Each humanized immunog ...


2
Cary L Queen, Harold E Selick: Humanized immunoglobulins. Protein Design Labs, Townsend and Townsend and Crew, June 25, 1996: US05530101 (1356 worldwide citation)

Novel methods for producing, and compositions of, humanized immunoglobulins having one or more complementarity determining regions (CDR's) and possible additional amino acids from a donor immunoglobulin and a framework region from an accepting human immunoglobulin are provided. Each humanized immuno ...


3
Cary L Queen, Man Sung Co, William P Schneider, Nicholas F Landolfi, Kathleen L Coelingh, Harold E Selick: Humanized immunoglobulins. Protein Design Labs, Townsend & Townsend & Crew, December 2, 1997: US05693762 (1197 worldwide citation)

Novel methods for producing, and compositions of, humanized immunoglobulins having one or more complementarity determining regions (CDR's) and possible additional amino acids from a donor immunoglobulin and a framework region from an accepting human immunoglobulin are provided. Each humanized immuno ...


4
Cary L Queen, Harold E Selick: Humanized immunoglobulins and methods of making the same. Protein Design Labs, Townsend and Townsend and Crew, January 30, 2001: US06180370 (811 worldwide citation)

Novel methods for producing, and compositions of, humanized immunoglobulins having one or more complementarity determining regions (CDR's) and possible additional amino acids from a donor immunoglobulin and a framework region from an accepting human immunoglobulin are provided. Each humanized i ...


5
Cary L Queen, William P Schneider, Harold E Selick: Polynucleotides encoding improved humanized immunoglobulins. Protein Design Labs, Townsend and Townsend and Crew, December 2, 1997: US05693761 (692 worldwide citation)

Novel methods for producing, and compositions of, humanized immunoglobulins having one or more complementarity determining regions (CDR's) and possible additional amino acids from a donor immunoglobulin and a framework region from an accepting human immunoglobulin are provided. Each humanized immuno ...


6
Man Sung Co, David A Scheinberg, Cary L Queen: Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region. Protein Design Labs, Sloan Kettering Cancer Center, Townsend and Townsend and Crew, February 3, 1998: US05714350 (203 worldwide citation)

The present invention provides methods for producing mutationally-altered immunoglobulins and compositions containing such mutationally-altered immunoglobulins, wherein the mutationally-altered immunoglobulins have at least one mutation that alters the pattern of glycosylation in a variable region a ...


7
Nicholas F Landolfi: Chimeric ligand/immunoglobulin molecules and their uses. Protein Design Labs, Townsend and Townsend Khourie and Crew, September 20, 1994: US05349053 (184 worldwide citation)

Chimeric molecules having a ligand component linked to an immunoglobulin constant region component are provided for various diagnostic, therapeutic and other uses. These immunoligands can exhibit the high degree of specificity associated with the ligand, yet retain various effector functions charact ...


8
Man Sung Co, David A Scheinberg, Cary L Queen: Antibodies with increased binding affinity. Protein Design Labs, Memorial Sloan Kettering Cancer Center, Townsend & Townsend & Crew, February 26, 2002: US06350861 (176 worldwide citation)

The present invention provides methods for producing mutationally-altered immunoglobulins and compositions containing such mutationally-altered immunoglobulins, wherein the mutationally-altered immunoglobulins have at least one mutation that alters the pattern of glycosylation in a variable region a ...


9
Queen Cary L, Selick Harold Edwin: Chimeric immunoglobulins specific for p55 tac protein of the il-2 receptor.. Protein Design Labs, October 16, 1991: EP0451216-A1 (153 worldwide citation)

Novel methods for designing humanized immunoglobulins having one or more complementary determining regions (CDR's) from a donor immunoglobulin and a framework region from a human immunoglobulin comprising first comparing the framework or variable region amino acid sequence of the donor immunoglobuli ...


10
J Yun Tso, Michael S Cole, Claudio Anasetti: Mutated nonactivating IgG2 domains and anti CD3 antibodies incorporating the same. Protein Design Labs, Townsend and Townsend and Crew, November 10, 1998: US05834597 (102 worldwide citation)

The invention provides mutated IgG2 constant regions and anti-CD3 antibodies incorporating the same. Such antibodies specifically bind to the CD3 antigen on T-cells but induce reduced mitogenic response compared with otherwise identical antibodies bearing natural IgG2 constant regions. The antibodie ...