1
Vladimir Kozlov, Irena Tsyrlova: Inhibitor of stem cell proliferation and uses thereof. Pro Neuron, Nixon & Vanderhye P C, February 8, 2000: US06022848 (51 worldwide citation)

Disclosed and claimed are methods for the isolation and use of stem cell inhibiting factors for regulating the abnormal stem cell cycle and for accelerating the post-chemotherapy peripheral blood cell recovery. Also disclosed and claimed are the inhibitors of stem cell proliferation.


2
Reid W von Borstel: Compositions and methods for treatment of mitochondrial diseases. Pro Neuron, Nixon & Vanderhye, October 29, 2002: US06472378 (43 worldwide citation)

Compounds, compositions, and methods are provided for treatment of disorders related to mitochondrial dysfunction. The methods comprise administering to a mammal a composition containing pyrimidine nucleotide precursors in amounts sufficient to treat symptoms resulting from mitochondrial respiratory ...


3
Reld W von Borstel, Michael K Bamat: Method of delivering exogenous uridine or cytidine using acylated uridine or cytidine. Pro Neuron, Nixon & Vanderhye, November 28, 1995: US05470838 (32 worldwide citation)

Methods of delivering exogenous uridine or cytidine to the tissue of an animal comprising the administration of acyl derivatives of uridine or cytidine, respectively, are disclosed. Also disclosed are methods for treating cardiac insufficiency, myocardial infarction, cirrhosis of the liver, each com ...


4
Reid von Borstel, Michael K Bamat: Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides. Pro Neuron, Nixon & Vanderhye, October 19, 1999: US05968914 (32 worldwide citation)

The subject invention discloses compounds, compositions and methods for treatment and prevention of toxicity due to chemotherapeutic agents and antiviral agents. Disclosed are acylated derivatives of non-methylated pyrimidine nucleosides. These compounds are capable of attenuating damage to the hema ...


5
Reid W von Borstel, Michael K Bamat: Compositions of chemotherapeutic agent or antiviral agent with acylated pyrimidine nucleosides. Pro Neuron, Nixon & Vanderhye, April 7, 1998: US05736531 (31 worldwide citation)

The subject invention discloses compounds, compositions and methods for treatment and prevention of toxicity due to chemotherapeutic agents and antiviral agents. Disclosed are acylated derivatives of non-methylated pyrimidine nucleosides. These compounds are capable of attenuating damage to the hema ...


6
Reid W von Borstel, Michael K Bamat, Bradley M Hiltbrand: Acylated pyrimidine nucleosides for treatment of systemic inflammation and inflammatory hepatitis. Pro Neuron, Nixon & Vanderhye P C, November 25, 1997: US05691320 (27 worldwide citation)

Pyrimidine nucleotide precursors including acyl derivatives of cytidine, uridine, and orotate, and uridine phosphorylase inhibitors, and their use in enhancing resistance to sepsis or systemic inflammation are disclosed.


7
Reid Warren von Borstel, Michael Kevin Bamat: Pharmaceutical compositions containing deoxyribonucleosides for wound healing. Pro Neuron, Nixon & Vanderhye, June 23, 1998: US05770582 (25 worldwide citation)

The invention relates to compositions comprising 2'-deoxyribonucleosides. The invention also relates to methods of accelerating the healing of wounds, abrasions, cuts, incisions, and superficial burns induced by heat, sunlight, chemical agents, or infections, and methods for ameliorating the effects ...


8
John H Kenten, David M Simpson: Compounds and methods for the selective treatment of cancer and bacterial infections. Pro Neuron, Nixon & Vanderhye, April 17, 2001: US06218519 (22 worldwide citation)

The present invention relates to compounds containing an anthracyclinone group such as doxorubicin, daunorubicin or a derivative thereof. The compounds of the invention also contain ester, glycoside or glucuronide structures which are hydrolyzed by the corresponding esterase, glycosidase or glucuron ...


9
Reid von Borstel, Michael K Bamat: Acylated uridine and cytidine for elevating tissue uridine and cytidine. Pro Neuron, Nixon & Vanderhye P C, December 10, 1996: US05583117 (21 worldwide citation)

General methods for delivering exogenous cytidine or uridine to the tissue of an animal comprising the administration of acylated cytidine or acylated uridine, respectively, are disclosed. Methods of treating myocardial infarction and cardiac insufficiency comprising the administration of acylated c ...


10
Reid W von Borstel, Michael K Bamat: Methods for promoting wound healing with deoxyribonucleosides. Pro Neuron, Nixon & Vanderhye, September 21, 1993: US05246708 (20 worldwide citation)

Methods are provided for promoting wound healing in animals by administering compositions containing two or more of the following 2'-deoxyribonucleosides: 2'-deoxyadenosine, 2'-deoxyguanosine, 2'-deoxy-cytidine, or thymidine. 3'- and 5'-phosphate derivatives of these 2'-deoxynucleosides are also eff ...