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Grondard Luc, Casimir Jean Paul, Leon Patrick, O Brien Michael K, Powers Matthew R, Robin Daniel: Stereospecific preparation of chiral 1-aryl- and 1-heteroaryl-2-substituted ethyl-2-amines. Rhone Poulenc Rorer Pharmaceuticals, Grondard Luc, Casimir Jean Paul, Leon Patrick, O Brien Michael K, Powers Matthew R, Robin Daniel, PARKER Raymond S III, March 19, 1998: WO/1998/011064

This invention is directed to methods for stereospecifically preparing [(1-optionally substituted aryl)- or (1-optionally substituted heteroaryl)]-2-substituted ethyl-2-amines, having chirality at the 2-position, and to intermediates to the substituted ethyl-2-amines.


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Airey John E, Powers Matthew R, Rodriguez Walter, Youssefyeh Raymond D: 2,6-methano-2h-1-benzoxocincarboxamides as 5-ht¿3?-antagonists. Rhone Poulenc Rorer International, Airey John E, Powers Matthew R, Rodriguez Walter, Youssefyeh Raymond D, NICHOLSON James A, June 11, 1992: WO/1992/009284

Novel compounds which are 2,6-methano-2H-1-benzoxocincarboxamides having 5-HT¿3?-antagonist properties including unique CNS, anti-emetic and gastric prokinetic activities and which are void of any significant D¿2? receptor binding affinity, processes for their preparation, therapeutic compositions a ...


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Airey John E, Studt William L, Powers Matthew R, Woodward Rick G, Golec Frederick A, Rodriguez Walter: Process for preparing multicyclic oxy-containing ring components. Rhone Poulenc Rorer International, Airey John E, Studt William L, Powers Matthew R, Woodward Rick G, Golec Frederick A, Rodriguez Walter, NICHOLSON James A, June 11, 1992: WO/1992/009592

This invention relates to stereospecific processes for the preparation, separation and purification of multicyclic oxy-containing ring system compounds such as dibenzofuran and benzoxocine-type compounds which exhibit 5HT¿3?-antagonist properties including unique CNS, anti-emetic and gastric prokine ...


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Powers Matthew R, Golec Frederick A: Asymmetric synthesis of hexahydrodibenzofurans by stereospecific inversion of ortho substituted 2-phenylcyclohexanols. Rhone Poulenc Rorer International, Powers Matthew R, Golec Frederick A, NICHOLSON James A, January 20, 1994: WO/1994/001428

This invention relates to the stereospecific process for the preparation, separation and purification of hexahydrodibenzofurans which are used in the preparation of the 5HT¿3? compounds. More specifically, the present invention relates to a process for the preparation of substantially optically pure ...


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Powers Matthew R, Youssefyeh Raymond D, Studt William L, Golec Fredrick A: Stereoselective preparation of acid sensitive amides and intermediates useful in said preparation. Rhone Poulenc Rorer International, Powers Matthew R, Youssefyeh Raymond D, Studt William L, Golec Fredrick A, NICHOLSON James A, April 2, 1992: WO/1992/005146

This invention is directed to a stereoselective process and useful intermediates for the preparation of substantially optically pure acid sensitive compounds including certain dibenzofuran-carboxamides and dibenzofurancarboxamide acids.


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