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Conte Immacolata, Ercolani Caterina, Narjes Frank, Pompei Marco, Rowley Michael, Stansfield Ian: Tetracyclic indole derivatives as antiviral agents. Istituto Di Ricerche Di Biologia Molecolare P Angeletti, Conte Immacolata, Ercolani Caterina, Narjes Frank, Pompei Marco, Rowley Michael, Stansfield Ian, MAN Jocelyn, May 4, 2006: WO/2006/046030 (59 worldwide citation)

The present invention relates to tetracyclic indole compounds of formula (I); wherein R1, R2, A, Ar, W, X, Y and Z are defined herein, and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising them, and their use for the treatment or prevention of infection by hepatitis C ...


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Liverton Nigel J, Summa Vincenzo, Vacca Joseph P, Di, Francesco Maria Emilia, Pompei Marco: Hcv ns3 protease inhibitors. Merck & Co, Istituto Di Ricerche Di Biologia Molecolare P Angeletti, Liverton Nigel J, Summa Vincenzo, Vacca Joseph P, Di, Francesco Maria Emilia, Pompei Marco, LAKE Julie M, May 2, 2008: WO/2008/051477 (56 worldwide citation)

The present invention relates to macrocyclic compounds of formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use treating or preventing HCV infections.


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Avolio Salvatore, Di, Filippo Marcello, Harper Steven, Narjes Frank, Pacini Barbara, Pompei Marco, Rowley Michael, Stansfield Ian: Indole acetamides as inhibitors of the hepatitis c virus ns5b polymerase. Istituto Di Ricerche Di Biologia Molecolare P Angeletti, Avolio Salvatore, Di, Filippo Marcello, Harper Steven, Narjes Frank, Pacini Barbara, Pompei Marco, Rowley Michael, Stansfield Ian, MAN Jocelyn, October 14, 2004: WO/2004/087714 (36 worldwide citation)

The present invention relates to indole and azaindole compounds of formula (I): wherein X1, X2, X3, X4, A1, Ar1, R1, R2 and n are as defined herein, and pharmaceutically acceptable salts thereof, useful in the prevention and treatment of hepatitis C infections.


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Botta Maurizio, Crescenzi Cristina, Mancinetti Daniele, Pompei Marco, Bonifacio Fausto: Diastereoselective process for the preparation of the antiviral agent4-amino-1-(2r-hydroxymethyl-[1,3]oxathiolan-5s-yl)-1h-pyrimidin-2-one. Recordati, Botta Maurizio, Crescenzi Cristina, Mancinetti Daniele, Pompei Marco, Bonifacio Fausto, GERVASI Gemma, May 15, 2003: WO/2003/040139

Process for the synthesis of 4-amino-1-(2R-hydroxymethyl - [1,3]oxathiolan-5S-yl)-1H-pyrimidin-2-one (LAMIVUDINE) comprising the reduction of 2-(R)-(4'-(R)acetonyl)-5-oxo-1,3-oxathiolan to give 2-(R)-(4'-(R)-acetonyl)-5-hydroxy-1,3-oxathiolan.