1
Holy Antonin, Otmar Miroslav, Piskala Alois: Method of manufacturing 1-(2-deoxy-alpha-d-erythro-pentofuranosyl)-5-azacytosine. Ustav Organicke Chemie A Biochemie Av Cr Vvi, Holy Antonin, Otmar Miroslav, Piskala Alois, GABRIELOVA Marta, August 28, 2008: WO/2008/101448 (2 worldwide citation)

This invention relates to a method of manufacturing 1-(2-deoxy-alpha-D-erythro-pentofuranosyl)-5-azacytosine by the treatment of protected alkyl or aralkyl 2-deoxy-D-erythro-pentofuranoside with silylated 5-azacytosine in the presence of Lewis acid and subsequent removal the protecting groups.


2
Holy Antonin, Krecmerov√° Marcela, Piskala Alois, Andrei Graciela, Snoeck Robert, de, Clercq Erik, Neyts Johan, Naesens Lieve: Azacytosine derivatives useful as antiviral agents. Ku Leuven Research & Development, Institute Of Organic Chemistry And Biochemistry Ofacademy Of Sciences Of The Czech Republic, Holy Antonin, Krecmerov√° Marcela, Piskala Alois, Andrei Graciela, Snoeck Robert, de, Clercq Erik, Neyts Johan, Naesens Lieve, sBIRD Ariane, June 14, 2007: WO/2007/065231

The present invention provides 5-azacytosine derivatives with antiviral activity, specifically having viral replication inhibiting properties, more particularly in DNA viruses such as pox-, papilloma- and herpes viruses in humans. The invention also provides pharmaceutical compositions comprising su ...


3
Holy Antonin, Otmar Miroslav, Piskala Alois, Votruba Ivan, Kovarik Ales, Fojtova Miloslava, Bartova Eva: 1-(2-deoxy-alpha-d-erythro-pentofuranosyl)-5-azacytosine for use as drug. Ustav Organicke Chemie A Biochemie Av Cr Vvi, Holy Antonin, Otmar Miroslav, Piskala Alois, Votruba Ivan, Kovarik Ales, Fojtova Miloslava, Bartova Eva, GABRIELOVA Marta, July 17, 2008: WO/2008/083634

The invention relates to 1-(2-deoxy-alpha-D-erythro-pentofuranosyl)-5-azacytosine of formula (I) for use as a hypomethylating drug applicable for epigenetic therapy of cancer and other epigenetically determined diseases and further includes the use of the compound of formula (I) for manufacturing of ...