1
Prockop Darwin J, Colter David, Digirolamo Carla: Isolation and expansion of human marrow stromal cells. Philadelphia Health &Amp, Educatio, August 7, 2002: EP1227825-A1 (2 worldwide citation)

The invention includes in vitro methods of inducing and enhancing proliferation of human marrow stromal cells for use in, for example, gene therapy and transplantation methods. The invention also includes a method of assessing the expandability (i.e., proliferative capacity) of human marrow stromal ...


2
Class Reiner Dr Ph D: Use of histones for the early diagnosis and/or preventive therapy of virus-infected living cells and a biochip for implementation of the diagnosis. Symbiotec, Philadelphia Health &Amp, Educatio, November 9, 2005: EP1593385-A1

Biologically active substance (I), preferably for early diagnosis and/or preventive therapy of virus-infected living cells, comprises at least one component of histone, covalent modified histone, similar histone polypeptide, biologically active sequences of the histone and similar histone peptide. - ...


3
Black Ira B, Woodbury Dale L, Prockop Darwin M, Schwartz Emily: Differentiation of bone marrow cells into neuronal cells and uses therefor. Philadelphia Health &Amp, Educatio, Univ New Jersey Med, January 8, 2003: EP1272614-A1

The present invention relates to methods of inducing differentiation of mammalian bone marrow stromal cells into neuronal cells by contacting marrow stromal cells with neuronal differentiation-inducing compounds. Neuronal differentiation-inducing compounds of the invention include anti-oxidants such ...


4
Prockop Darwin J, Reiss Russell G, Langell John: Stromal cell use. Philadelphia Health &Amp, Educatio, August 22, 2001: EP1124428-A1

The invention relates to the use of marrow stromal cells to enhance hematopoiesis in a mammal.


5
Black Ira B, Woodbury Dale L, Prockop Darwin M, Schwartz Emily: Differentiation of bone marrow cells into neuronal cells and uses therefor. Philadelphia Health &Amp, Educatio, Univ New Jersey Med, February 7, 2007: EP1749884-A1

The present invention relates to methods of inducing differentiation of mammalian bone marrow stromal cells into neuronal cells by contacting marrow stromal cells with neuronal differentiation-inducing compounds. Neuronal differentiation-inducing compounds of the invention include anti-oxidants such ...


6
Stearns Mark, Hu Youji, Wang Min: Prostate cancer-related compositions, methods, and kits based on dna macroarray proteomics platforms. Philadelphia Health &Amp, Educatio, February 23, 2005: EP1507787-A2

The invention relates to novel nucleic acids encoding a mammalian PCADM-1 gene, and proteins encoded thereby, whose expression is increased in certain diseases, disorders, or conditions, including, but not limited to, prostate cancer. The invention further relates to methods of detecting and treatin ...


7
Stearns Mark E, Hu Youji: A pcam-1 marker protein, nucleic acid sequences encoding pcam-1 and immunoassays for detection of pcam-1. Philadelphia Health &Amp, Educatio, July 17, 2002: EP1222307-A1

The present invention provides a cancer marker protein, PCAM-1, and polynucleotides which identify and encode this protein. Detection of this marker is useful in diagnosing and prognosticating cancer in a patient. Also provided are expression vectors and host cells for expression of PCAM-1 as well a ...


8
Longton Wallace A, Miyamoto Curtis, Rukstalis Daniel: A graduated intraluminal catheter and methods of use thereof. Philadelphia Health &Amp, Educatio, December 6, 2000: EP1056489-A2

Graduated catheters including, but not limited to, graduated urethral and ureteric catheters are provided, the catheters each comprising a catheter tube, an expandable portion, and at least one indicator. The position of at least one indicator may be determined by an extracorporeal imaging method. A ...


9
Tuszynski George, Williams Taffy J: Angiocidin: a cys-ser-val-thr-cys-gly specific tumor cell adhesion receptor. Inkine Pharmaceutical Company, Philadelphia Health &Amp, Educatio, Tuszynski George, Williams Taffy J, June 27, 2001: EP1109900-A1

The present invention provides the sequence of a cell matrix receptor specific for the Cys-Ser-Val-Thr-Cys-Gly (SEQ ID NO:1) region of thrombospondin. Also provided are purification, cloning and expression methods. The receptor protein is useful in numerous diagnostic, prophylactic and therapeutic a ...


10
Jameson Bradford A, Tretiakova Anna S, Albert Ross, Davidson Harold Carter: Immunomodulation and effect on cell processes relating to serotonin family receptors. Philadelphia Health &Amp, Educatio, March 31, 2004: EP1401410-A2

The present invention relates to the discovery that signaling via a serotonin type 1B, 2, 4 and 6 receptor is important in T cell activation such that inhibiting such signaling can be used to modulate the immune response. This immunomodulation is useful for the treatment of immune diseases or condit ...



Click the thumbnails below to visualize the patent trend.