1
Bock Larry, Daniels R Hugh, Empedocles Stephen, Niu Chumming, Owicki John C, Sahi Vijendra, Chow Calvin, Pontis George: Nano-chem-fet based biosensors. Nanosys, Bock Larry, Daniels R Hugh, Empedocles Stephen, Niu Chumming, Owicki John C, Sahi Vijendra, Chow Calvin, Pontis George, QUINE Jonathan Alan, April 22, 2004: WO/2004/034025 (78 worldwide citation)

Methods of detecting a component of interest, a change in charge, a pH, a cellular response using nanosensors are provided. Nanosensors, including nanowires and nanowire arrays comprising functionalized and/or non-functionalized nanowires are provided. Nanosensors are used for detection in cellular ...


2
Modlin Douglas N, French Todd E, Petersen Jon F, Owicki John C: Methods and apparatus for detecting polynucleotide hybridization. Ljl Biosystems, Modlin Douglas N, French Todd E, Petersen Jon F, Owicki John C, ABNEY James R, July 20, 2000: WO/2000/042209

Methods and apparatus for detecting polynucleotide hybridization in luminescence-based assays. The methods may include (1) contacting a sample polynucleotide with a reference polynucleotide at an assay site, where at least one of the polynucleotides is capable of emitting luminescence, (2) illuminat ...


3
French Todd E, Modlin Douglas N, Owicki John C, Richey James S, Leytes Lev J, Razvi Enal S, Zhang Klompus Yan, Panfili Peter R: Methods and apparatus for detecting nucleic acid polymorphisms. Ljl Biosystems, French Todd E, Modlin Douglas N, Owicki John C, Richey James S, Leytes Lev J, Razvi Enal S, Zhang Klompus Yan, Panfili Peter R, ABNEY James R, September 21, 2000: WO/2000/055372

Methods and apparatus for detecting polynucleotide hybridization in luminescence-based assays. The methods may include (1) allele-specific hybridization, using luminescence detection, (2) allele-specific oligonucleotide ligation, using dye-labeled oligonucleotide ligation with luminescence resonance ...


4
Terpetschnig Ewald A, Owicki John C, Deshpande Sudhir S: Improvements in luminescence assays. Ljl Biosystems, Terpetschnig Ewald A, Owicki John C, Deshpande Sudhir S, ABNEY James R, April 27, 2000: WO/2000/023785

Apparatus, methods, compositions, and kits for improved luminescence assays. These improvements include, among others, the use of mass labeling in luminescence polarization assays, diffusion enhancements in luminescence resonance energy transfer assays, and labeled and/or unlabeled particulates in v ...


5
Owicki John C, Modlin Douglas N, French Todd E: Apparatus and methods for identifying quenching effects in luminescence assays. Ljl Biosystems, Owicki John C, Modlin Douglas N, French Todd E, ABNEY James R, February 10, 2000: WO/2000/006989

Apparatus and methods for identifying and correcting for quenching in luminescence assays using luminescence lifetimes and/or luminescence intensities. One aspect of the invention involves identifying quenching using combinations of luminescence lifetimes and/or intensities. Another aspect of the in ...


6
Modlin Douglas N, French Todd E, Owicki John C: Apparatus and methods for time-resolved spectroscopic measurements. Ljl Biosystems, Modlin Douglas N, French Todd E, Owicki John C, ABNEY James R, February 10, 2000: WO/2000/006990

Apparatus and method for measuring light transmitted from a sample. The apparatus may include a stage (123), a light source (103), and a detector (145). The stage (123) may be configured to hold a microplate (124) having a plurality of sample wells (126). The apparatus may be configured to take freq ...


7
Modlin Douglas N, Petersen Jon F, Owicki John C: Apparatus and methods for spectroscopic measurements. Ljl Biosystems, Modlin Douglas N, Petersen Jon F, Owicki John C, ABNEY James R, February 10, 2000: WO/2000/006991

Apparatus and Methods for measuring light transmitted from a sample. The apparatus may include a stage (123), a light source (103a-103d), and a detector (145a-145d, 160). The stage (123) may be configured to hold a microplate (124) having a plurality of sample wells. The apparatus may be configured ...


8
Terpetschnig Ewald A, Yang Dan Hui, Owicki John C, Zhang Yan: Luminescent metal-ligand complexes. Ljl Biosystems, Terpetschnig Ewald A, Yang Dan Hui, Owicki John C, Zhang Yan, ABNEY James R, August 17, 2000: WO/2000/047693

Luminescent metal-ligand complexes and/or complementary energy trnsfer acceptors for use in luminescence assays. The complexes and/or acceptors may be use in free, reactive, and/or conjugated form, alone or mixed with other compounds. Preferred luminescence assays include luminescence polarization a ...


9
Modlin Douglas N, French Todd E, Owicki John C: Apparatus and methods for improving signal resolution in optical spectroscopy. Ljl Biosystems, Modlin Douglas N, French Todd E, Owicki John C, ABNEY James R, July 29, 1999: WO/1999/037203

Apparatus, methods, and compositions of matter for improving signal resolution in optical spectroscopy assays. The apparatus may include components for detecting light emitted by an analyte in a composition. These components may include (1) a stage for supporting the composition, (2) a light source ...


10
Modlin Douglas N, Owicki John C: Apparatus and methods for measuring fluorescence polarization. Ljl Biosystems, Modlin Douglas N, Owicki John C, ABNEY James R, May 14, 1999: WO/1999/023466

An apparatus (90) for measuring polarized light emitted from a composition that includes a stage configured to hold a microplate (124) having an array of sample wells (126), a continuous high color temperature light source (100), and a detector (144). An excitation optical relay structure directs li ...