1
Arnold I Caplan, Stephen E Haynesworth: Human mesenchymal stem cells. Osiris Therapeutics, Charles J Herron, Elliot M Olstein, January 23, 1996: US05486359 (515 worldwide citation)

Isolated human mesenchymal stem cells which can differentiate into more than one tissue type (e.g. bone, cartilage, muscle or marrow stroma), a method for isolating, purifying, and culturally expanding human mesenchymal stem cells (i.e. "mesenchymal stem cells" or "hMSCs"), and characterization of a ...


2
Arnold I Caplan, Stephen E Haynesworth: Connective tissue regeneration using human mesenchymal stem cell preparations. Osiris Therapeutics, Charles J Herron, Elliot M Olstein, September 22, 1998: US05811094 (264 worldwide citation)

Isolated human mesenchymal stem cells, a method for isolating, purifying, and culturally expanding human mesenchymal stem cells (i.e. mesenchymal stem cells or "MSCs"), and characterization of (including by cytokine expression profiling) and uses, particularly research reagent, diagnostic and therap ...


3
Victor M Goldberg, Arnold I Caplan, Francis P Barry, David J Fink, Daniel R Marshak, James S Burns: Osteoarthritis cartilage regeneration. Osiris Therapeutics, Elliot M Olstein, Raymond J Lillie, December 28, 2004: US06835377 (194 worldwide citation)

For repair of cartilage damaged as part of the degenerative effects of osteoarthritis, the inventors have found that the human mesenchymal stem cell approach makes it possible to: (1) regenerate both shallow cartilage chondral defects and full thickness cartilage defects (osteochondral lesions); (2) ...


4
Mark F Pittenger, Stephen L Gordon, Alastair Morgan Mackay: Cardiac muscle regeneration using mesenchymal stem cells. Osiris Therapeutics, Elliot M Olstein, Raymond J Lillie, May 14, 2002: US06387369 (168 worldwide citation)

Disclosed is a method for producing cardiomyocytes in vivo by administering to the heart of an individual a cardiomyocyte producing amount of mesenchymal stem cells. These cells can be administered as a liquid injectible or as a preparation of cells in a matrix which is or becomes solid or semi-soli ...


5
Scott P Bruder, Kevin R McIntosh, Daniel R Marshak, Joseph D Mosca: Uses for non-autologous mesenchymal stem cells. Osiris Therapeutics, Elliot M Olstein, Alan J Grant, March 12, 2002: US06355239 (166 worldwide citation)

Methods and devices using non-autologous mesenchymal stem cells comprising treating a recipient in need thereof with an effective amount of non-autologous mesenchymal stem cells, including methods and preparations for treating and regenerating connective tissue and enhancing bone marrow engraftment ...


6
Scott P Bruder, Arnold I Caplan, Stephen E Haynesworth: Lineage-directed induction of human mesenchymal stem cell differentiation. Case Western Reserve University, Osiris Therapeutics, Elliot M Olstein, Raina Semionow, August 24, 1999: US05942225 (153 worldwide citation)

Methods for in vitro or ex vivo lineage directed induction of isolated, culture expanded human mesenchymal stem cells comprising contacting the mesenchymal stem cells with a bioactive factor effective to induce differentiation thereof into a lineage of choice as well as such compositions including i ...


7
Janice M Davis Sproul, Mark Aaron Moorman, Renee Marie McNeil, Donald William Simonetti Jr, Lora Catherine Hammill, Stewart Craig: Human mesenchymal stem cells. Osiris Therapeutics, Elliot M Olstein, Raymond J Lillie, May 14, 2002: US06387367 (145 worldwide citation)

Human mesenchymal stem cells having the phenotype SH3+, CD45+ can be isolated. These precursor mesenchymal item cells are useful for treatment of patients in need of mensenchymal stem cell.


8
Mireya Fernández, José J Minguell: Human mesenchymal stem cells from peripheral blood. Osiris Therapeutics, Elliot M Olstein, Raymond J Lillie, July 17, 2001: US06261549 (127 worldwide citation)

Disclosed is a method for recovering peripheral blood containing a population of cells enhanced in human mesenchymal stem cells from an individual by (i) administering to said individual at least one growth factor and, thereafter, (ii) recovering peripheral blood from said individual. The growth fac ...


9
Mark F Pittenger: Adipogenic differentiation of human mesenchymal stem cells. Osiris Therapeutics, Charles J Herron, Elliot M Olstein, October 27, 1998: US05827740 (122 worldwide citation)

A composition which comprises human mesenchymal stem cells which have the potential to differentiate into cells of more than one connective tissue type and a composition which induces cells from the mesenchymal stem cell population to differentiate into the adipogenic lineage, and a process for indu ...


10
Sudhakar Kadiyala, Scott P Bruder: Regeneration and augmentation of bone using mesenchymal stem cells. Osiris Therapeutics, Elliot M Olstein, Raymond J Lillie, April 1, 2003: US06541024 (111 worldwide citation)

Disclosed are compositions and methods for augmenting bone formation by administering isolated human mesenchymal stem cells (hMSCs) with a ceramic material or matrix or by administering hMSCs; fresh, whole marrow; or combinations thereof in a resorbable biopolymer which supports their differentiatio ...