Hartop William L: Expandable drug delivery device. Ortho Pharmaceutical Corporation, Lambert Benjamin F, February 11, 1975: US3865108 (174 worldwide citation)

A drug delivery device having a drug containing zone associated with and partially defined by a material which swells on contact with body fluids. When swelling occurs, the pressure on the drug containing zone expels the drug from the device.

Gordon W Holmes: Instrument and method for inserting an intrauterine contraceptive device. Ortho Pharmaceutical Corporation, Benjamin F Lambert, March 13, 1979: US04143656 (122 worldwide citation)

An instrument for inserting an intrauterine contraceptive device of the kind having one or more outwardly extending arms or protrusions is described. The insertion instrument comprising an inserter tube and coacting rod maintains the arm or arms of the device in an extended configuration during stor ...

Derral Mayberry, Jawahar Sawardeker, John McShefferty: Method and apparatus for inserting an intrauterine contraceptive device. Ortho Pharmaceutical Corporation, Benjamin F Lambert, May 31, 1977: US04026281 (115 worldwide citation)

A method of inserting an intrauterine contraceptive device is described. The device is mounted in a plunger and the plunger containing the device is inserted into a hollow insertion tube for insertion into the uterine cavity.

Pramod M Kotwal, Stephen A Howard: Multilayered controlled release pharmaceutical dosage form. Ortho Pharmaceutical Corporation, March 7, 1995: US05395626 (107 worldwide citation)

This invention is directed to a multilayered controlled release pharmaceutical dosage form. More particularly the dosage form is adapted for water soluble drugs and comprises a plurality of coated particles wherein each has multiple layers about a core containing a drug active whereby the drug conta ...

George Heavner, Foe Siong Tjoeng, Gideon Goldstein: Immunoregulatory diketopiperazine compounds. Ortho Pharmaceutical Corporation, Geoffrey G Dellenbaugh, September 15, 1981: US04289759 (105 worldwide citation)

Immunoregulatory 2,5-diketopiperazine compounds of formula: ##STR1## wherein m is 1 or 2 and n is 3 or 4 possess the ability to regulate the immune system of humans and animals. Administration of the compounds will return to a normal state an immune system in need of regulation.

Roger Homm, Gilbert Katz: Pharmaceutical formulation applicator device. Ortho Pharmaceutical Corporation, Benjamin F Lambert, August 23, 1977: US04043338 (93 worldwide citation)

A device for introducing pharmaceutical formulations into a body orifice is described. The device consists of a hollow tube constructed of a rigid but flexible material which is closed at at least one end. A freely sliding, rigid tube or rod is contained within the hollow tube and is attached to one ...

Jeffrey A Bluestone, Robert A Zivin, Linda K Jolliffe: Methods and materials for modulation of the immunosuppressive activity and toxicity of monoclonal antibodies. Arch Development Corporation, Ortho Pharmaceutical Corporation, Arnold White & Durkee, March 23, 1999: US05885573 (87 worldwide citation)

The binding specificity of the murine OKT3 has been transferred into a human antibody framework in order to reduce its immunogenicity. This "humanized" anti-CD3 mAb (gOKT3-5) was previously shown to retain, in vitro, all the properties of native OKT3, including T cell activation which has been corre ...

Homm Roger, Katz Gilbert: Composition for sustained release of a medicament and method of using same. Ortho Pharmaceutical Corporation, Lambert Benjamin F, April 1, 1975: US3875300 (81 worldwide citation)

A solid, intimately admixed composition comprising a thermoplastic, physiologically-inert polymer soluble in body fluids, and an effective amount of a suitable medicament. The composition is suitable for introduction into a body cavity, therein to be slowly dissolved by body fluids and release there ...

Diane C Corbo, Mary Jean M Link, N Adeyinka Williams, Michelle L Tomsho, Michael Bornstein, Howard F Solomon, Scott K Larsen, Robert L Suddith: Lyophilized imaging agent formulation comprising a chemotactic peptide. Ortho Pharmaceutical Corporation, Johnson Matthey, Sterne Kessler Goldstein & Fox P L L C, February 15, 2000: US06024938 (79 worldwide citation)

A lyophilized imaging agent formulation and methods for making same are disclosed, such formulations comprise a targeting molecule such as antibody or chemotactic peptide, a linker such as diethylenetriaminepentaacetic acid (DTPA) or succinimidyl 6-hydrazinium nicotinate hydrochloride (SHNH), drying ...

Donald Miffitt, Edward Poto, George Hovorka, Arthur Costaris: Apparatus and method for measuring a bodily constituent. Ortho Pharmaceutical Corporation, Joel R Petrow, January 12, 1993: US05179288 (66 worldwide citation)

An apparatus and method for measuring a bodily constituent such as glucose or cholesterol by analyzing a sample taken from the body such as blood, saliva or urine. The sample is placed on a test strip inserted into the test block portion of the apparatus where the portion of the sample containing th ...