1
Irina A Nazarenko, Satish K Bhatnagar, Emily S Winn Deen, Robert J Hohman: Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon. Oncor, Jonathan M Oncor Cohen, February 2, 1999: US05866336 (286 worldwide citation)

The present invention provides labeled nucleic acid amplification oligonucleotides, which can be linear or hairpin primers or blocking oligonucleotides. The oligonucleotides of the invention are labeled with donor and/or acceptor moieties of molecular energy transfer pairs. The moieties can be fluor ...


2
Satish K Bhatnagar, Albert L George Jr, Irina Nazarenko: Amplification of nucleic acid sequences. Oncor, Glenn E Karta, January 14, 1997: US05593840 (74 worldwide citation)

A process for amplifying nucleic acid sequences from a DNA or RNA template which may be purified, or may exist in a mixture of nucleic acids. The resulting nucleic acid sequences may be exact copies of the template, or may be modified. The process has advantages over prior art amplification processe ...


3
Nrusingha C Mishra, Hossein S Khorshidi, Yuxiang Gan, Pam Szweda, Jay George: Modified nucleotides for nucleic acid labeling. Oncor, Glenn E Karta, November 4, 1997: US05684142 (55 worldwide citation)

Modified pyrimidine bases and nucleotides containing a linker arm and a detectable reporter group for nucleic acid labeling. The modified nucleotides have the structure: ##STR1## wherein: -R.sub.1 is --H or --OH;


4
Albert L George Jr, Satish K Bhatnagar, Irina Nazarenko: Method for analyzing a nucleotide sequence. Oncor, Glenn E Karta, March 17, 1998: US05728526 (54 worldwide citation)

A method for analyzing a target nucleotide sequence which exists in a first state or a different second state which makes the method particularly useful for determining point mutations. The method uses a first polynucleotide which is immobilized on a solid support and which is at least partially com ...


5
John P Kennealy: Method and apparatus for processing images. Oncor, Burns Doane Swecker & Mathis L, June 9, 1998: US05764792 (51 worldwide citation)

A method and apparatus for detecting rare cells in a biological sample is disclosed. A color image of the sample is generated and the color image is decomposed into its color components. A first mask is then generated based upon a first color characteristic of the rare cells. At least one color comp ...


6
Mary Ge Wang, Albert Louis George Jr, Elizabeth Sophia Light: Method for the detection of chromosome structural abnormalities by in situ hybridization to fixed tissue. Oncor, Glenn E Karta, January 5, 1999: US05856089 (43 worldwide citation)

The present invention is directed to in situ hybridization methods using nucleic acid probes for single copy sequences for detecting chromosomal structural abnormalities in fixed tissue obtained from a patient suspected of having a chromosomal structural abnormality.


7
Albert L George Jr: Restriction amplification assay. Oncor, Burns Doane Swecker & Mathis, April 7, 1992: US05102784 (25 worldwide citation)

The present invention relates to a method, reagent and kit for the determination of the presence of target nucleotide sequences by restriction amplification. In the process to detect nucleic acid sequences a target molecule containing a specific restriction site is hybridized with a labeled probe co ...


8
Jack D Love, Michael T Elliott, Patricia L Morgan, Leo G Woerner: Process for conducting electrophoresis and transfer. Oncor, Burns Doane Swecker & Mathis, March 27, 1990: US04911816 (17 worldwide citation)

An apparatus for carrying out horizontal gel electrophoresis for separation and subsequent vacuum-assisted transportation of macromolecules to a support membrane to facilitate detection. The entire procedure is conducted in one cartridge. A method for conducting electrophoresis and subsequent vacuum ...


9
George Albert L Jr: Restriction amplification assay.. Oncor, November 6, 1991: EP0455517-A1 (14 worldwide citation)

A method, reagent and kit for the determination of the presence of target nucleotide sequences by restriction amplification are disclosed. In the process to detect nucleic acid sequences a target molecule containing a specific restriction site is hybridized with a labeled probe containing a sequence ...


10
Jack D Love, Michael T Elliott, Patricia L Morgan: Process and apparatus for conducting electrophoresis and transfer. Oncor, Burns Doane Swecker & Mathis, February 23, 1988: US04726889 (11 worldwide citation)

An apparatus for carrying out horizontal gel electrophoresis for separation and subsequent vacuum-assisted transportation of macromolecules to a support membrane to facilitate detection. The entire procedure is conducted in one cartridge. A method for conducting electrophoresis and subsequent vacuum ...