1
Johnson Alan T, Kaneko Satoru, Mohan Raju, Oda Kozo, Schweiger Edwin J: Isoquinolinone derivatives and their use as therapeutic agents. X Ceptor Therapeutics, Sankyo Company, Johnson Alan T, Kaneko Satoru, Mohan Raju, Oda Kozo, Schweiger Edwin J, ROTH Carol J, July 15, 2004: WO/2004/058717 (47 worldwide citation)

This invention is directed to isoquinolinone derivatives and their use in modulating the activity of orphan nuclear receptors, pharmaceutical compositions containing such derivatives, and methods of using such derivatives in treating disease-states associated with nuclear receptor activity.


2
Tamaki Kazuhiko, Yamaguchi Takahiro, Oda Kozo, Terasaka Naoki, Nakai Daisuke, Nakadai Masakazu: (Ja) 2以上の置換基を有するベンゼン化合物, (En) Benzene compound having 2 or more substituents. Daiichi Sankyo Company, Tamaki Kazuhiko, Yamaguchi Takahiro, Oda Kozo, Terasaka Naoki, Nakai Daisuke, Nakadai Masakazu, YAGUCHI Toshiaki, May 4, 2006: WO/2006/046593 (45 worldwide citation)

(EN) Disclosed is an excellent LXR modulator. Specifically disclosed is a compound represented by the general formula (I) below or the like. (I) [In the formula, R1 represents a -COR9 (wherein R9 represents an alkyl, optionally substituted alkoxy or optionally substituted amino); R2 represents an H, ...


3
Arai Masami, Kaneko Satoru, Shibuya Satoshi, Watanabe Tsuyoshi, Oda Kozo: (Ja) 置換された縮環ピリミジン-4(3h)-オン化合物, (En) Substituted fused pyrimidine-4(3h)-one compound. Sankyo Company, X Ceptor Therapeutics, Arai Masami, Kaneko Satoru, Shibuya Satoshi, Watanabe Tsuyoshi, Oda Kozo, KUMAKURA Yoshio, March 17, 2005: WO/2005/023782 (10 worldwide citation)

(EN) A compound represented by the general formula (I): (I) [wherein A is phenyl, etc.; R1 is R1a (R1a is substituted alkyl, etc.), -Z1b-R1b (R1b is substituted alkyl, etc. and Z1b is -NH-, etc.), -Z1c-R1c (R1c has the same meaning as R1b or is alkyl and Z1c is -C≡C-, etc.), -N(R1b)(R1c), etc.; R2 a ...


4
Kaneko Satoru, Watanabe Tsuyoshi, Oda Kozo, Mohan Raju, Schweiger Edwin J, Martin Richard: Fused-ring pyrimidin-4(3h)-one derivatives, processes for the preparation and uses thereof. Sankyo Company, X Ceptor Therapeutics, Kaneko Satoru, Watanabe Tsuyoshi, Oda Kozo, Mohan Raju, Schweiger Edwin J, Martin Richard, NAKAMURA Minoru, December 24, 2003: WO/2003/106435 (1 worldwide citation)

AbstractNovel compounds of the following formula (I) and pharmacologically acceptable salt and esters thereof can modulate LXR function and as a result show excellent anti-arteriosclerotic and anti-inflammatory activity:wherein:A represents aryl or heteroaryl;R¿1?, R¿2? and R¿3? are the same or diff ...


5
Yoshida Akira, Oda Kozo, Kasai Takashi, Koga Teiichiro, Hasegawa Kazuo: Tricyclic heterocyclic compound. Sankyo Company, Yoshida Akira, Oda Kozo, Kasai Takashi, Koga Teiichiro, Hasegawa Kazuo, NAKAMURA Minoru, April 1, 1993: WO/1993/006096

[Constitution] A tricyclic heterocyclic compound represented by general formula (I) wherein R?1¿ and R?2¿ represent each hydrogen, lower alkyl, lower alkoxy, halogen or halogenated lower alkyl; R?3¿ represents hydrogen or lower alkyl; R?4¿ represents substituted phenyl or naphthyl; R?5¿ represents h ...


6
Yoshida Akira, Kogen Hiroshi, Hayakawa Ichiro, Oda Kozo, Kasai Takashi, Simada Kousei, Yoshida Yumi, Ishihara Sadao, Saito Fujio, Ohhata Yasuo, Koga Teiichiro, Kitazawa Eiichi, Tokui Taro: N-phenylated amide and urea derivatives. Sankyo Company, Yoshida Akira, Kogen Hiroshi, Hayakawa Ichiro, Oda Kozo, Kasai Takashi, Simada Kousei, Yoshida Yumi, Ishihara Sadao, Saito Fujio, Ohhata Yasuo, Koga Teiichiro, Kitazawa Eiichi, Tokui Taro, NAKAMURA Minoru, February 8, 1996: WO/1996/003378

Novel N-phenylated amide and urea derivatives represented by general formula (I) and salts thereof, which have excellent ACAT inhibitory activity and peroral absorbability and are useful as a remedy and/or a preventive for arteriosclerosis, wherein R?1a¿ represents C¿1?-C¿12? alkyl or cycloalkyl-alk ...